Search Results - "Cotterill, Sue"

Role of Drosophila in Human Disease Research 3.0 by Cotterill, Sue, Yamaguchi, Masamitsu

“…has become a commonly used animal model for biomedical research in a variety of areas [...]…”
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Association of Mutations in Replicative DNA Polymerase Genes with Human Disease: Possible Application of Drosophila Models for Studies by Yamaguchi, Masamitsu, Cotterill, Sue

“…Replicative DNA polymerases, such as DNA polymerase α-primase, δ and ε, are multi-subunit complexes that are responsible for the bulk of nuclear DNA…”
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Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication by Soriano, Ignacio, Vazquez, Enrique, De Leon, Nagore, Bertrand, Sibyl, Heitzer, Ellen, Toumazou, Sophia, Bo, Zhihan, Palles, Claire, Pai, Chen-Chun, Humphrey, Timothy C, Tomlinson, Ian, Cotterill, Sue, Kearsey, Stephen E

“…Somatic and germline mutations in the proofreading domain of the replicative DNA polymerase ε (POLE-exonuclease domain mutations, POLE-EDMs) are frequently…”
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Novel roles of HP1a and Mcm10 in DNA replication, genome maintenance and photoreceptor cell differentiation by Vo, Nicole, Anh Suong, Dang Ngoc, Yoshino, Natsuki, Yoshida, Hideki, Cotterill, Sue, Yamaguchi, Masamitsu

“…Both Mcm10 and HP1a are known to be required for DNA replication. However, underlying mechanism is not clarified yet especially for HP1. Knockdown of both HP1a…”
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Drosophila Mcm10 is required for DNA replication and differentiation in the compound eye by Vo, Nicole, Taga, Ayano, Inaba, Yasuhiro, Yoshida, Hideki, Cotterill, Sue, Yamaguchi, Masamitsu

“…Mini chromosome maintenance 10 (Mcm10) is an essential protein, which is conserved from S. cerevisiae to Drosophila and human, and is required for the…”
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The DNA polymerases of Drosophila melanogaster by Marygold, Steven J., Attrill, Helen, Speretta, Elena, Warner, Kate, Magrane, Michele, Berloco, Maria, Cotterill, Sue, McVey, Mitch, Rong, Yikang, Yamaguchi, Masamitsu

“…DNA synthesis during replication or repair is a fundamental cellular process that is catalyzed by a set of evolutionary conserved polymerases. Despite a large…”
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Drosophila RecQ4 is directly involved in both DNA replication and the response to UV damage in S2 cells by Crevel, Gilles, Vo, Nicole, Crevel, Isabelle, Hamid, Sana, Hoa, Lily, Miyata, Seiji, Cotterill, Sue

“…The RecQ4 protein shows homology to both the S.cerevisiae DNA replication protein Sld2 and the DNA repair related RecQ helicases. Experimental data also…”
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The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells by Crevel, Gilles, Bennett, Dorothy, Cotterill, Sue

“…The human TTC4 protein is a TPR (tetratricopeptide repeat) motif-containing protein. The gene was originally identified as being localized in a genomic region…”
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Decreased MCM2-6 in Drosophila S2 cells does not generate significant DNA damage or cause a marked increase in sensitivity to replication interference by Crevel, Isabelle, Crevel, Gilles, Gostan, Thierry, de Renty, Christelle, Coulon, Vincent, Cotterill, Sue

“…A reduction in the level of some MCM proteins in human cancer cells (MCM5 in U20S cells or MCM3 in Hela cells) causes a rapid increase in the level of DNA…”
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Role of IDrosophila/I in Human Disease Research 3.0 by Cotterill, Sue, Yamaguchi, Masamitsu

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Association of Mutations in Replicative DNA Polymerase Genes with Human Disease: Possible Application of IDrosophila/I Models for Studies by Yamaguchi, Masamitsu, Cotterill, Sue

“…Replicative DNA polymerases, such as DNA polymerase α-primase, δ and ε, are multi-subunit complexes that are responsible for the bulk of nuclear DNA…”
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Differential requirements for MCM proteins in DNA replication in Drosophila S2 cells by Crevel, Gilles, Hashimoto, Reina, Vass, Sharron, Sherkow, Jake, Yamaguchi, Masamitsu, Heck, Margarete M S, Cotterill, Sue

“…The MCM2-7 proteins are crucial components of the pre replication complex (preRC) in eukaryotes. Since they are significantly more abundant than other preRC…”
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A simple bypass assay for DNA polymerases shows that cancer‐associated hypermutating variants exhibit differences in vitro by Crevel, Gilles, Kearsey, Stephen, Cotterill, Sue

“…Errors made by DNA polymerases contribute to both natural variation and, in extreme cases, genome instability and its associated diseases. Recently, the…”
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Importin-α3 Is Required at Multiple Stages of Drosophila Development and Has a Role in the Completion of Oogenesis by Máthé, Endre, Bates, Helen, Huikeshoven, Hella, Deák, Péter, Glover, David M., Cotterill, Sue

“…The Drosophila importin-α3 gene was isolated through its interaction with the large subunit of the DNA polymerase α in a two-hybrid screen. The predicted…”
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Forced binding of the origin of replication complex to chromosomal sites in Drosophila S2 cells creates an origin of replication by Crevel, Gilles, Cotterill, Sue

“…Origins of replication in higher eukaryotes appear to lack specific sequence characteristics and those mapped often appear to be spread over several kilobases…”
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Df31 is a novel nuclear protein involved in chromatin structure in Drosophila melanogaster by Crevel, G, Huikeshoven, H, Cotterill, S

“…We originally isolated the Df31 protein from Drosophila embryo extracts as a factor which could decondense Xenopus sperm, by removing the sperm specific…”
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Human DNA polymerase ε is a source of C>T mutations at CpG dinucleotides by Tomkova, Marketa, McClellan, Michael John, Crevel, Gilles, Shahid, Akbar Muhammed, Mozumdar, Nandini, Tomek, Jakub, Shepherd, Emelie, Cotterill, Sue, Schuster-Böckler, Benjamin, Kriaucionis, Skirmantas

“…C-to-T transitions in CpG dinucleotides are the most prevalent mutations in human cancers and genetic diseases. These mutations have been attributed to…”
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Drosophila telomere capping protein HOAP interacts with DSB sensor proteins Mre11 and Nbs by On, Kinyo, Crevel, Gilles, Cotterill, Sue, Itoh, Masanobu, Kato, Yasuko

“…In eukaryotes, specific DNA‐protein structures called telomeres exist at linear chromosome ends. Telomere stability is maintained by a specific capping protein…”
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The role of insulators and transcription in 3D chromatin organization of flies by Chathoth, Keerthi T, Mikheeva, Liudmila A, Crevel, Gilles, Wolfe, Jareth C, Hunter, Ioni, Beckett-Doyle, Saskia, Cotterill, Sue, Dai, Hongsheng, Harrison, Andrew, Zabet, Nicolae Radu

“…The DNA in many organisms, including humans, is shown to be organized in topologically associating domains (TADs). In , several architectural proteins are…”
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Expression of the cancer-associated DNA polymerase [epsilon] P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication by Soriano, Ignacio, Vazquez, Enrique, De Leon, Nagore, Bertrand, Sibyl, Heitzer, Ellen, Toumazou, Sophia, Bo, Zhihan, Palles, Claire, Pai, Chen-Chun, Humphrey, Timothy C, Tomlinson, Ian, Cotterill, Sue, Kearsey, Stephen E

“…Somatic and germline mutations in the proofreading domain of the replicative DNA polymerase [epsilon] (POLE-exonuclease domain mutations, POLE-EDMs) are…”
Get full text