Search Results - "Cotter, F. E."

Phase I Clinical and Pharmacokinetic Study of Bcl-2 Antisense Oligonucleotide Therapy in Patients With Non-Hodgkin’s Lymphoma by WATERS, J. S, WEBB, A, CUNNINGHAM, D, CLARKE, P. A, RAYNAUD, F, DI STEFANO, F, COTTER, F. E

“…To evaluate the pharmacokinetics and toxicity of an antisense oligonucleotide targeting bcl-2 in patients with non-Hodgkin's lymphoma (NHL) and to determine…”
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t(11;18)(q21;q21) is the most common translocation in MALT lymphomas by Auer, I. A., Gascoyne, R. D., Conners, J. M., Cotter, F. E., Greiner, T. C., Sanger, W. G., Horsman, D. E.

“…Background Low grade malignant lymphomas arising from mucosa associated lymphoid tissue (MALT) represent a distinct clinicopathological entity. The cytogenetic…”
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Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species by FENNELL, D. A, CORBO, M, PALLASKA, A, COTTER, F. E

“…Resistance to apoptosis is a major obstacle preventing effective therapy for malignancy. Mitochondria localized anti-death proteins of the Bcl-2 family play a…”
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Monosomy 7 and 7q- associated with myeloid malignancy by Johnson, E., Cotter, F.E.

“…An association between the complete or partial loss of chromosome 7 and preleukaemic myelodysplasia or acute myeloid leukaemia has been recognized from the…”
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The significance of circulating cells carrying t(14;18) in long remission from follicular lymphoma by Price, C G, Meerabux, J, Murtagh, S, Cotter, F E, Rohatiner, A Z, Young, B D, Lister, T A

“…Peripheral blood mononuclear cell fractions from 15 patients in continuous clinical remission from follicular lymphoma for longer than 10 years were examined…”
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Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model by Cotter, F E, Johnson, P, Hall, P, Pocock, C, al Mahdi, N, Cowell, J K, Morgan, G

“…The t(14;18) translocation is found in the majority follicular lymphomas and some high grade B-cell lymphomas. This is results in deregulation of the BCL-2…”
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Detection of cells bearing the t(14;18) translocation following myeloablative treatment and autologous bone marrow transplantation for follicular lymphoma by Johnson, P W, Price, C G, Smith, T, Cotter, F E, Meerabux, J, Rohatiner, A Z, Young, B D, Lister, T A

“…To use the polymerase chain reaction (PCR) technique for molecular assessment of the results of myeloablative treatment of follicular lymphoma with autologous…”
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Molecular Definition of a Narrow Interval at 7q22.1 Associated With Myelodysplasia by Johnson, E.J., Scherer, S.W., Osborne, L, Tsui, L.C., Oscier, D., Mould, S., Cotter, F.E.

“…Chromosome 7 translocations, deletions, or monosomy are associated with myelodysplasia (MDS) and acute myeloid leukemia both in children and adults. These…”
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Variability of polymerase chain reaction detection of the bcl-2-IgH translocation in an international multicentre study by Johnson, P. W. M., Swinbank, K., MacLennan, S., Colomer, D., Debuire, B., Diss, T., Gabert, J., Gupta, R. K., Haynes, A., Kneba, M., Lee, M. S., Macintyre, E., Mensink, E., Moos, M., Morgan, G. J., Neri, A., Johnson, A., Reato, G., Salles, G., van't Veer, M. B., Zehnder, J. L., Zucca, E., Selby, P. J., Cotter, F. E.

“…Background: The capacity of the polymerase chain reaction (PCR) to detect very low numbers of cells bearing a t(14;18) translocation has led to its application…”
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Stochastic modelling of apoptosis kinetics by Fennell, D A, Pallaska, A, Corbo, M, Cotter, F E

“…Robust quantitative estimation of average whole cell mitochondrial dysfunction is a useful tool for assessing sensitivity to apoptotic stimuli induced either…”
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Antisense therapy of hematologic malignancies by Cotter, F E

“…Many tumor cells are inherently resistant to curative treatment due to an altered pattern of gene expression. It is an attractive and logical proposition to…”
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Assessment of cell death by COTTER, F. E

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The class II tumour suppressor gene RARRES3 maps to 11q12, not 11q23 by Auer, R L, Bertoni, F, Jones, C, Cotter, F E

“…Leukemia (2002) 16, 1396. doi:10.1038/sj.leu.2402505…”
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Genetic alteration associated with chronic lymphocytic leukemia by Cotter, F E, Auer, R L

“…The genetics of B-cell chronic lymphocytic leukemia (B-CLL) differ considerably from most other forms of hematologic malignancy which are usually characterized…”
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Early postischemic dantrolene-induced amelioration of poly(ADP-ribose) polymerase-related bioenergetic failure in neonatal rat brain slices by Tasker, R C, Sahota, S K, Cotter, F E, Williams, S R

“…In the infant brain, ischemia-induced ionic and enzyme mechanisms may independently lead to cell death by energy depletion: resequestration of calcium…”
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Pk11195, a mitochondrial benzodiazepine receptor antagonist, reduces apoptosis threshold in Bcl-XL and Mcl-1 expressing human cholangiocarcinoma cells by Okaro, A C, Fennell, D A, Corbo, M, Davidson, B R, Cotter, F E

“…Background: Cholangiocarcinoma cells express high levels of the antiapoptotic proteins Bcl-XL and Mcl-1 and are markedly chemo- and radioresistant…”
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Antisense therapy for lymphomas by Cotter, Finbarr E.

“…The potential ability of antisense oligonucleotides to downregulate the expression of oncogenes involved in lymphoma, with minimal toxicity can be achieved…”
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BCL-2 expression by leukaemic blasts in a SCID mouse model of biphenotypic leukaemia associated with the t(4;11)(q21;q23) translocation by Pocock, C F, Malone, M, Booth, M, Evans, M, Morgan, G, Greil, J, Cotter, F E

“…Acute leukaemia of infancy is associated with abnormalities at chromosome band 11q23, and has a poor prognosis. The gene involved. Mixed Lineage Leukaemia…”
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Cytogenetic and molecular study of 32 Down syndrome families: potential leukaemia predisposing role of the most proximal segment of chromosome 21q by Cavani, Simona, Perfumo, Chiara, Argusti, Alessandra, Pierluigi, Mauro, Perroni, Lucia, Schmiegelow, Kjeld, Petersen, Michael B., Cotter, Finbarr E., Strigini, Paolo, Dagna‐Bricarelli, Franca, NižetiĆ, Dean

“…Down syndrome (DS) children have a 10–20‐fold increased risk of developing ALL or AML compared to non‐DS children. An increased disomic homozygosity of the…”
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An immunohistological and genotypic study of the plasma cell form of Castleman's disease by Hall, P A, Donaghy, M, Cotter, F E, Stansfeld, A G, Levison, D A

“…The plasma cell variant of Castleman's disease (angiofollicular hyperplasia) is an uncommon and poorly understood lymphoproliferative disorder which may be…”
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