Search Results - "Cottam, Howard B."

Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses by Goff, Peter H, Hayashi, Tomoko, Martínez-Gil, Luis, Corr, Maripat, Crain, Brian, Yao, Shiyin, Cottam, Howard B, Chan, Michael, Ramos, Irene, Eggink, Dirk, Heshmati, Mitra, Krammer, Florian, Messer, Karen, Pu, Minya, Fernandez-Sesma, Ana, Palese, Peter, Carson, Dennis A

“…Current vaccines against influenza virus infection rely on the induction of neutralizing antibodies targeting the globular head of the viral hemagglutinin…”
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Structure–Activity Relationship Studies of Pyrimido[5,4‑b]indoles as Selective Toll-Like Receptor 4 Ligands by Chan, Michael, Kakitsubata, Yuhei, Hayashi, Tomoko, Ahmadi, Alast, Yao, Shiyin, Shukla, Nikunj M, Oyama, Shin-ya, Baba, Akihito, Nguyen, Brandon, Corr, Maripat, Suda, Yasuo, Carson, Dennis A, Cottam, Howard B, Wakao, Masahiro

“…Previous high throughput screening studies led to the discovery of two novel, nonlipid-like chemotypes as Toll-like receptor 4 (TLR4) agonists. One of these…”
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Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides by Shinchi, Hiroyuki, Crain, Brian, Yao, Shiyin, Chan, Michael, Zhang, Shannon S, Ahmadiiveli, Alast, Suda, Yasuo, Hayashi, Tomoko, Cottam, Howard B, Carson, Dennis A

“…Toll-like receptors (TLRs) in the innate immune system recognize specific pathogen-associated molecular patterns derived from microbes. Synthetic small…”
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Identification of Substituted Pyrimido[5,4‑b]indoles as Selective Toll-Like Receptor 4 Ligands by Chan, Michael, Hayashi, Tomoko, Mathewson, Richard D, Nour, Afshin, Hayashi, Yuki, Yao, Shiyin, Tawatao, Rommel I, Crain, Brian, Tsigelny, Igor F, Kouznetsova, Valentina L, Messer, Karen, Pu, Minya, Corr, Maripat, Carson, Dennis A, Cottam, Howard B

“…A cell-based high-throughput screen to identify small molecular weight stimulators of the innate immune system revealed substituted pyrimido­[5,4-b]­indoles as…”
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Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia by Wu, Raymond P., Hayashi, Tomoko, Cottam, Howard B., Jin, Guangyi, Yao, Shiyin, Wu, Christina C. N., Rosenbach, Michael D., Corr, Maripat, Schwab, Richard B., Carson, Dennis A.

“…Recent studies show that redox-active small molecules are selectively cytotoxic to chronic lymphocytic leukemia (CLL). Although elevated levels of reactive…”
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Synthesis and immunostimulatory activity of sugar-conjugated TLR7 ligands by Baba, Akihito, Wakao, Masahiro, Shinchi, Hiroyuki, Chan, Michael, Hayashi, Tomoko, Yao, Shiyin, Cottam, Howard B., Carson, Dennis A., Suda, Yasuo

“…[Display omitted] Toll-like receptors (TLRs) are a type of pattern recognition receptors (PRRs), which are activated by recognizing pathogen-associated…”
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Molecular Basis for the Immunostimulatory Activity of Guanine Nucleoside Analogs: Activation of Toll-like Receptor 7 by Lee, Jongdae, Chuang, Tsung-Hsien, Redecke, Vanessa, She, Liping, Pitha, Paula M., Carson, Dennis A., Raz, Eyal, Cottam, Howard B.

“…Certain C8-substituted and N7, C8-disubstituted guanine ribonucleosides comprise a class of small molecules with immunostimulatory activity. In a variety of…”
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Generation and Application of a Reporter Cell Line for the Quantitative Screen of Extracellular Vesicle Release by Shpigelman, Jonathan, Lao, Fitzgerald S, Yao, Shiyin, Li, Chenyang, Saito, Tetsuya, Sato-Kaneko, Fumi, Nolan, John P, Shukla, Nikunj M, Pu, Minya, Messer, Karen, Cottam, Howard B, Carson, Dennis A, Corr, Maripat, Hayashi, Tomoko

“…Extracellular vesicles (EVs) are identified as mediators of intercellular communication and cellular regulation. In the immune system, EVs play a role in…”
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A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity by Sato-Kaneko, Fumi, Yao, Shiyin, Lao, Fitzgerald S, Shpigelman, Jonathan, Messer, Karen, Pu, Minya, Shukla, Nikunj M, Cottam, Howard B, Chan, Michael, Chu, Paul J, Burkhart, David, Schoener, Roman, Matsutani, Takaji, Carson, Dennis A, Corr, Maripat, Hayashi, Tomoko

“…The limited efficacy of seasonal influenza vaccines is usually attributed to ongoing variation in the major antigenic targets for protective antibody responses…”
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Induction of Tolerogenic Dendritic Cells by a PEGylated TLR7 Ligand for Treatment of Type 1 Diabetes by Hayashi, Tomoko, Yao, Shiyin, Crain, Brian, Promessi, Victor J, Shyu, Luke, Sheng, Caroline, Kang, McNancy, Cottam, Howard B, Carson, Dennis A, Corr, Maripat

“…Autoimmune diabetes mellitus (DM) results from the destruction of pancreatic islet cells by activated T lymphocytes, which have been primed by activated…”
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Co-Delivery of a Novel Lipidated TLR7/8 Agonist and Hemagglutinin-Based Influenza Antigen Using Silica Nanoparticles Promotes Enhanced Immune Responses by Abdelwahab, Walid M, Auclair, Sarah, Borgogna, Timothy, Siram, Karthik, Riffey, Alexander, Bazin, Hélène G, Cottam, Howard B, Hayashi, Tomoko, Evans, Jay T, Burkhart, David J

“…Co-delivery of antigens and adjuvants to the same antigen-presenting cells (APCs) can significantly improve the efficacy and safety profiles of vaccines. Here,…”
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Activation of the Wnt Signaling Pathway in Chronic Lymphocytic Leukemia by Lu, Desheng, Zhao, Yandong, Tawatao, Rommel, Cottam, Howard B., Sen, Malini, Leoni, Lorenzo M., Kipps, Thomas J., Corr, Maripat, Carson, Dennis A.

“…B cell chronic lymphocytic leukemia (CLL) is characterized by an accumulation of mature, functionally incompetent B cells. Wnts are a large family of secreted…”
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A Triple High Throughput Screening for Extracellular Vesicle Inducing Agents With Immunostimulatory Activity by Shukla, Nikunj M, Sato-Kaneko, Fumi, Yao, Shiyin, Pu, Minya, Chan, Michael, Lao, Fitzgerald S, Sako, Yukiya, Saito, Tetsuya, Messer, Karen, Hayashi, Tomoko, Cottam, Howard B, Corr, Maripat, Carson, Dennis A

“…Extracellular vesicles (EVs) play an important role in intercellular communication and regulation of cells, especially in the immune system where EVs can…”
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Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge by Saito, Tetsuya, Sako, Yukiya, Sato-Kaneko, Fumi, Hosoya, Tadashi, Yao, Shiyin, Lao, Fitzgerald S, Shpigelman, Jonathan, Messer, Karen, Pu, Minya, Shukla, Nikunj M, Chan, Michael, Chu, Paul J, Cottam, Howard B, Hayashi, Tomoko, Carson, Dennis A, Corr, Maripat

“…As viruses continue to mutate the need for rapid high titer neutralizing antibody responses has been highlighted. To meet these emerging threats, agents that…”
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Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Hosoya, Tadashi, Shukla, Nikunj M, Fujita, Yuya, Yao, Shiyin, Lao, Fitzgerald S, Baba, Hiroyuki, Yasuda, Shinsuke, Cottam, Howard B, Carson, Dennis A, Hayashi, Tomoko, Corr, Maripat

“…In recent years target based drug discovery has expanded our therapeutic armamentarium in the treatment of inflammatory and autoimmune diseases. Despite these…”
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Synthesis and Immunological Characterization of Toll-Like Receptor 7 Agonistic Conjugates by Chan, Michael, Hayashi, Tomoko, Kuy, Crystal S, Gray, Christine S, Wu, Christina C. N, Corr, Maripat, Wrasidlo, Wolfgang, Cottam, Howard B, Carson, Dennis A

“…Activation of toll-like receptors (TLRs) on cells of the innate immune system initiates, amplifies, and directs the antigen-specific acquired immune response…”
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Activation of Anti-Hepatitis C Virus Responses via Toll-like Receptor 7 by Lee, Jongdae, Wu, Christina C. N., Lee, Ki Jeong, Chuang, Tsung-Hsien, Katakura, Kyoko, Liu, Yu-Tsueng, Chan, Michael, Tawatao, Rommel, Chung, Michelle, Shen, Carol, Cottam, Howard B., Lai, Michael M. C., Raz, Eyal, Carson, Dennis A.

“…IFN-α is used to suppress the replication of hepatitis C virus (HCV) in chronically infected patients with partial success. Here we present evidence showing…”
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A Dual Adjuvant System for Intranasal Boosting of Local and Systemic Immunity for Influenza Vaccination by Sato-Kaneko, Fumi, Yao, Shiyin, Lao, Fitzgerald S, Sako, Yukiya, Jin, Jasmine, Shukla, Nikunj M, Cottam, Howard B, Chan, Michael, Belsuzarri, Masiel M, Carson, Dennis A, Hayashi, Tomoko

“…Systemically vaccinated individuals against COVID-19 and influenza may continue to support viral replication and shedding in the upper airways, contributing to…”
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Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand by Wu, Christina C.N, Hayashi, Tomoko, Takabayashi, Kenji, Sabet, Mojgan, Smee, Donald F, Guiney, Donald D, Cottam, Howard B, Carson, Dennis A

“…The immunotherapeutic activity of Toll-like receptor (TLR) activators has been difficult to exploit because of side effects related to the release and systemic…”
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Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system by Hayashi, Tomoko, Yao, Shiyin, Crain, Brian, Chan, Michael, Tawatao, Rommel I, Gray, Christine, Vuong, Linda, Lao, Fitzgerald, Cottam, Howard B, Carson, Dennis A, Corr, Maripat

“…The Toll-like receptors (TLR) have been advocated as attractive therapeutic targets because TLR signaling plays dual roles in initiating adaptive immune…”
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