Search Results - "Cotreau, Monette M"

The influence of age and sex on the clearance of cytochrome P450 3A substrates by COTREAU, Monette M, VON MOLTKE, Lisa L, GREENBLATT, David J

“…Cytochrome P450s (CYPs) are an important family of enzymes in the metabolism of many therapeutic agents and endogenous metabolic reactions. The CYP3A subfamily…”
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Commentary on “Sex and Gender Differences in Clinical Pharmacology: Implications for Transgender Medicine” by Cotreau, Monette M.

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Comparison of Human and Rat Uterine Leiomyomata: Identification of a Dysregulated Mammalian Target of Rapamycin Pathway by CRABTREE, Judy S, JELINSKY, Scott A, DAVE, Bhuvanesh, BROADDUS, Russell R, BROWN, Eugene L, WENLING KAO, SKOTNICKI, Jerauld S, ABOU-GHARBIA, Magid, WINNEKER, Richard C, WALKER, Cheryl L, HARRIS, Heather A, CHOE, Sung E, COTREAU, Monette M, KIMBERLAND, Michelle L, WILSON, Ewa, SARAF, Kathryn A, WEI LIU, MCCAMPBELL, Adrienne S

“…Uterine leiomyomata, or fibroids, are benign tumors of the uterine myometrium that significantly affect up to 30% of reproductive-age women. Despite being the…”
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Molecular Classification of Crohn's Disease and Ulcerative Colitis Patients Using Transcriptional Profiles in Peripheral Blood Mononuclear Cells by Burczynski, Michael E., Peterson, Ron L., Twine, Natalie C., Zuberek, Krystyna A., Brodeur, Brendan J., Casciotti, Lori, Maganti, Vasu, Reddy, Padma S., Strahs, Andrew, Immermann, Fred, Spinelli, Walter, Schwertschlag, Ulrich, Slager, Anna M., Cotreau, Monette M., Dorner, Andrew J.

“…Ulcerative colitis (UC) and Crohn's disease (CD) are common inflammatory bowel diseases producing intestinal inflammation and tissue damage. Although emerging…”
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Effects of ketoconazole or rifampin on the pharmacokinetics of tivozanib hydrochloride, a vascular endothelial growth factor receptor tyrosine kinase inhibitor by Cotreau, Monette M., Siebers, Nicholas M., Miller, James, Strahs, Andrew L., Slichenmyer, William

“…The vascular endothelial growth factor (VEGF) pathway is associated with the promotion of endothelial cell proliferation, migration, and survival necessary for…”
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In vitro, pharmacokinetic, and pharmacodynamic interactions of ketoconazole and midazolam in the rat by Kotegawa, Tsutomu, Laurijssens, Bart E, Von Moltke, Lisa L, Cotreau, Monette M, Perloff, Michael D, Venkatakrishnan, Karthik, Warrington, Jill S, Granda, Brian W, Harmatz, Jerold S, Greenblatt, David J

“…Interactions of midazolam and ketoconazole were studied in vivo and in vitro in rats. Ketoconazole (total dose of 15 mg/kg intraperitoneally) reduced clearance…”
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Biologic and Clinical Activity of Tivozanib (AV-951, KRN-951), a Selective Inhibitor of VEGF Receptor-1, -2, and -3 Tyrosine Kinases, in a 4-Week-On, 2-Week-Off Schedule in Patients with Advanced Solid Tumors by ESKENS, Ferry A. L. M, DE JONGE, Maja J. A, VERWEIJ, Jaap, BHARGAVA, Pankaj, ISOE, Toshiyuki, COTREAU, Monette M, ESTEVES, Brooke, HAYASHI, Kunihiko, BURGER, Herman, THOMEER, Maarten, VAN DOORN, Leni

“…To assess the maximum tolerated dose (MTD)/dose-limiting toxicities (DLT), safety, pharmacokinetics, and pharmacodynamics of tivozanib, a potent and selective…”
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Developing antisense oligonucleotide and short-interfering RNA therapeutics - a few considerations by Cotreau, Monette M.

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Molecular analysis of the vaginal response to estrogens in the ovariectomized rat and postmenopausal woman by Jelinsky, Scott A, Choe, Sung E, Crabtree, Judy S, Cotreau, Monette M, Wilson, Ewa, Saraf, Kathryn, Dorner, Andrew J, Brown, Eugene L, Peano, Bryan J, Zhang, Xiaochun, Winneker, Richard C, Harris, Heather A

“…Vaginal atrophy (VA) is the thinning of the vaginal epithelial lining, typically the result of lowered estrogen levels during menopause. Some of the…”
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Unchanged cytochrome P450 3A (CYP3A) expression and metabolism of midazolam, triazolam, and dexamethasone in mdr(−/−) mouse liver microsomes by Perloff, Michael D, von Moltke, Lisa L, Cotreau, Monette M, Greenblatt, David J

“…P-Glycoprotein (P-gp) and cytochrome P450 3A (CYP3A) share common substrates and expression properties, but the relationship of mdr1 deficiency to…”
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Methodologies to study the induction of rat hepatic and intestinal cytochrome P450 3A at the mRNA, protein, and catalytic activity level by Cotreau, Monette M, von Moltke, Lisa L, Beinfeld, Margery C, Greenblatt, David J

“…Studies were conducted to characterize assays for the isolation and quantitation of rat cytochrome P450 (CYP) 3A isoforms from hepatic and intestinal tissues…”
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A Phase Ib Study of the VEGF Receptor Tyrosine Kinase Inhibitor Tivozanib and Modified FOLFOX-6 in Patients With Advanced Gastrointestinal Malignancies by Oldenhuis, Corina N, Loos, Walter J, Esteves, Brooke, van Doorn, Leni, Cotreau, Monette M, Strahs, Andrew L, den Hollander, Martha W, Gietema, Jourik A, de Vries, Elisabeth G.E, Eskens, Ferry A.L.M

“…Micro-Abstract Combining a modified (m)FOLFOX-6 (leucovorin, 5-fluorouracil [5-FU], and 85 mg/kg2 oxaliplatin) regimen with antiangiogenic therapy is a…”
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The Antiparasitic Moxidectin: Safety, Tolerability, and Pharmacokinetics in Humans by Cotreau, Monette M., Warren, Sarah, Ryan, John L., Fleckenstein, Lawrence, Vanapalli, Sreenivasa R., Brown, Kenneth R., Rock, David, Chen, Chieh-Yu, Schwertschlag, Ullrich S.

“…A study in healthy male volunteers was completed to evaluate the safety, tolerability, and pharmacokinetics of a single oral dose of the antiparasitic…”
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The effect of food on the pharmacokinetics of tivozanib hydrochloride by Cotreau, Monette M., Massmanian, Lisa, Strahs, Andrew L., Slichenmyer, William, Vargo, Dennis L.

“…Tivozanib hydrochloride (tivozanib) is a potent, selective tyrosine kinase inhibitor of the vascular endothelial growth factor receptors 1, 2, and 3, with a…”
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A study of 17β-estradiol-regulated genes in the vagina of postmenopausal women with vaginal atrophy by Cotreau, Monette M, Chennathukuzhi, Vargheese M, Harris, Heather A, Han, Lixin, Dorner, Andrew J, Apseloff, Glen, Varadarajan, Usha, Hatstat, Ellyn, Zakaria, Marjorie, Strahs, Andrew L, Crabtree, Judy S, Winneker, Richard C, Jelinsky, Scott A

“…Abstract Background Vaginal atrophy (VA) is a prevalent disorder in postmenopausal women that is characterized by decreased epithelial thickness, reduced…”
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Dose-Dependent Pharmacokinetics and Psychomotor Effects of Caffeine in Humans by Kaplan, Gary B., Greenblatt, David J., Ehrenberg, Bruce L., Goddard, Jill E., Cotreau, Monette M., Harmatz, Jerold S., Shader, Richard I.

“…Twelve healthy volunteers received oral placebo, 250 mg of caffeine, and 500 mg of caffeine in a randomized, double‐blind, single‐dose crossover study…”
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A Phase I cardiac safety and pharmacokinetic study of tivozanib hydrochloride in patients with advanced solid tumors by Moore, Kathleen, Infante, Jeffrey R., Cotreau, Monette M., Wilson, Lindsey, Strahs, Andrew L., Vargo, Dennis L., Chadha, Manpreet

“…Tivozanib hydrochloride (tivozanib) is a potent, selective tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors, with a long…”
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Absorption, Metabolism, and Excretion of [14C]-Tivozanib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Healthy Male Participants: A Phase I, Open-Label, Mass-Balance Study by Cotreau, Monette M., Hale, Christine L., Jacobson, Lindsey, Oelke, Claudine S., Strahs, Andrew L., Kochan, Robert G., Sanga, Madhu, Slichenmyer, William, Vargo, Dennis L.

“…Objective: To evaluate the absorption, metabolism, and excretion of tivozanib, a new investigational drug for renal cell carcinoma and solid malignancies…”
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A multiple-dose, safety, tolerability, pharmacokinetics and pharmacodynamic study of oral recombinant human interleukin-11 (oprelvekin) by Cotreau, Monette M., Stonis, Lucille, Strahs, Andrew, Schwertschlag, Ullrich S.

“…A study in healthy men and women was performed to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of orally administered…”
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Effects of benzodiazepine administration on A1 adenosine receptor binding in-vivo and ex-vivo by Kaplan, G B, Cotreau, M M, Greenblatt, D J

“…The adenosine receptor has been implicated in the central mechanism of action of benzodiazepines. The specific binding of an A1-selective adenosine antagonist…”
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