Search Results - "Cote, Colette A."
-
1
A Xenopus Protein Related to hnRNP I Has a Role in Cytoplasmic RNA Localization
Published in Molecular cell (01-09-1999)“…Cytoplasmic localization of mRNA molecules is a powerful mechanism for generating cell polarity. In vertebrates, one paradigm is localization of Vg1 RNA within…”
Get full text
Journal Article -
2
RNA sorting in Xenopus oocytes and embryos
Published in The FASEB journal (01-03-1999)“…ABSTRACT Cytoplasmic localization of mRNA molecules has emerged as a powerful mechanism for generating spatially restricted gene expression. This process is an…”
Get full text
Journal Article -
3
Trans-splicing Into Highly Abundant Albumin Transcripts for Production of Therapeutic Proteins In Vivo
Published in Molecular therapy (01-02-2009)“…Spliceosome-mediated RNA trans-splicing has emerged as an exciting mode of RNA therapy. Here we describe a novel trans-splicing strategy, which targets highly…”
Get full text
Journal Article -
4
Role of the ITS2-proximal stem and evidence for indirect recognition of processing sites in pre-rRNA processing in yeast
Published in Nucleic acids research (15-05-2001)“…Eucaryotic ribosome biogenesis involves many cis-acting sequences and trans-acting factors, including snoRNAS: We have used directed mutagenesis of rDNA…”
Get full text
Journal Article -
5
Two copies of a subelement from the Vg1 RNA localization sequence are sufficient to direct vegetal localization in Xenopus oocytes
Published in Development (Cambridge) (01-12-1997)“…Localization of mRNA has emerged as a fundamental mechanism for generating polarity during development. In vertebrates, one example of this phenomenon is Vg1…”
Get full text
Journal Article -
6
Dynamic conformational model for the role of ITS2 in pre-rRNA processing in yeast
Published in RNA (Cambridge) (01-06-2002)“…Maturation of the large subunit rRNAs includes a series of cleavages that result in removal of the internal transcribed spacer (ITS2) that separates mature…”
Get full text
Journal Article -
7
Conserved and clustered RNA recognition sequences are a critical feature of signals directing RNA localization in Xenopus oocytes
Published in Mechanisms of development (2004)“…Although it is widely regarded that the targeting of RNA molecules to subcellular destinations depends upon the recognition of cis-elements found within their…”
Get full text
Journal Article -
8
712. High Capacity Screen To Select Optimal Pre-Trans-Splicing Molecules for Trans-Splicing Applications
Published in Molecular therapy (01-05-2004)“…Spliceosome Mediated RNA Trans-splicing (SMaRT(TM)) is a platform technology to reprogram genes at the pre-mRNA level. Applications include RNA therapy and…”
Get full text
Journal Article