Search Results - "Costford, Sheila R."

Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK) by Chan, Kenny L., Pillon, Nicolas J., Sivaloganathan, Darshan M., Costford, Sheila R., Liu, Zhi, Théret, Marine, Chazaud, Benedicte, Klip, Amira

“…A rise in tissue-embedded macrophages displaying “M1-like” proinflammatory polarization is a hallmark of metabolic inflammation during a high fat diet or…”
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Skeletal muscle NAMPT is induced by exercise in humans by Costford, Sheila R, Bajpeyi, Sudip, Pasarica, Magdalena, Albarado, Diana C, Thomas, Shantele C, Xie, Hui, Church, Timothy S, Jubrias, Sharon A, Conley, Kevin E, Smith, Steven R

“…In mammals, nicotinamide phosphoribosyltransferase (NAMPT) is responsible for the first and rate-limiting step in the conversion of nicotinamide to…”
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Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance by Chan, Kenny L., Tam, Theresa H., Boroumand, Parastoo, Prescott, David, Costford, Sheila R., Escalante, Nichole K., Fine, Noah, Tu, YuShan, Robertson, Susan J., Prabaharan, Dilshaayee, Liu, Zhi, Bilan, Philip J., Salter, Michael W., Glogauer, Michael, Girardin, Stephen E., Philpott, Dana J., Klip, Amira

“…Insulin resistance is a chronic inflammatory condition accompanying obesity or high fat diets that leads to type 2 diabetes. It is hypothesized that lipids and…”
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G-quadruplex-mediated reduction of a pathogenic mitochondrial heteroplasmy by Naeem, Mansur M, Maheshan, Rathena, Costford, Sheila R, Wahedi, Azizia, Trajkovski, Marko, Plavec, Janez, Yatsunyk, Liliya A, Ciesielski, Grzegorz L, Kaufman, Brett A, Sondheimer, Neal

“…Abstract Disease-associated variants in mitochondrial DNA (mtDNA) are frequently heteroplasmic, a state of co-existence with the wild-type genome. Because…”
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Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance by Costford, Sheila R, Brouwers, Bram, Hopf, Meghan E, Sparks, Lauren M, Dispagna, Mauro, Gomes, Ana P, Cornnell, Heather H, Petucci, Chris, Phelan, Peter, Xie, Hui, Yi, Fanchao, Walter, Glenn A, Osborne, Timothy F, Sinclair, David A, Mynatt, Randall L, Ayala, Julio E, Gardell, Stephen J, Smith, Steven R

“…Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway that produces nicotinamide adenine dinucleotide (NAD ), an…”
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Elevated Nicotinamide Phosphoribosyl Transferase in Skeletal Muscle Augments Exercise Performance and Mitochondrial Respiratory Capacity Following Exercise Training by Brouwers, Bram, Stephens, Natalie A, Costford, Sheila R, Hopf, Meghan E, Ayala, Julio E, Yi, Fanchao, Xie, Hui, Li, Jian-Liang, Gardell, Stephen J, Sparks, Lauren M, Smith, Steven R

“…Mice overexpressing NAMPT in skeletal muscle (NamptTg mice) develop higher exercise endurance and maximal aerobic capacity (VO max) following voluntary…”
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Gain-of-Function R225W Mutation in Human AMPKγ3 Causing Increased Glycogen and Decreased Triglyceride in Skeletal Muscle by Costford, Sheila R, Kavaslar, Nihan, Ahituv, Nadav, Chaudhry, Shehla N, Schackwitz, Wendy S, Dent, Robert, Pennacchio, Len A, McPherson, Ruth, Harper, Mary-Ellen

“…Background AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme that is evolutionarily conserved from yeast to mammals and functions to maintain…”
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Male Mice Lacking NLRX1 Are Partially Protected From High-Fat Diet-Induced Hyperglycemia by Costford, Sheila R, Tattoli, Ivan, Duan, Francis T, Volchuk, Allen, Klip, Amira, Philpott, Dana J, Woo, Minna, Girardin, Stephen E

“…Abstract Nod-like receptor (NLR)X1 is an NLR family protein that localizes to the mitochondrial matrix and modulates reactive oxygen species production,…”
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Threshold age and burn size associated with poor outcomes in the elderly after burn injury by Jeschke, Marc G, Pinto, Ruxandra, Costford, Sheila R, Amini-Nik, Saeid

“…Highlights • In elderly, risk of death increased linearly with increasing age. • LD50 decreases from 45% TBSA to 25% TBSA from the age of 55 years to the age…”
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Pro‐Inflammatory macrophages increase in skeletal muscle of high fat‐Fed mice and correlate with metabolic risk markers in humans by Fink, Lisbeth N., Costford, Sheila R., Lee, Yun S., Jensen, Thomas E., Bilan, Philip J., Oberbach, Andreas, Blüher, Matthias, Olefsky, Jerrold M., Sams, Anette, Klip, Amira

“…Objective In obesity, immune cells infiltrate adipose tissue. Skeletal muscle is the major tissue of insulin‐dependent glucose disposal, and indices of muscle…”
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EFFECTS OF 12 MONTHS OF CALORIC RESTRICTION ON MUSCLE MITOCHONDRIAL FUNCTION IN HEALTHY INDIVIDUALS by Sparks, Lauren Marie, Redman, Leanne M, Conley, Kevin E, Harper, Mary-Ellen, Yi, Fanchao, Hodges, Andrew, Eroshkin, Alexey, Costford, Sheila R, Gabriel, Meghan E, Shook, Cherie, Cornnell, Heather H, Ravussin, Eric, Smith, Steven R

“…Context:The effects of caloric restriction (CR) on in vivo muscle mitochondrial function in humans are controversial.Objective:To evaluate muscle mitochondrial…”
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DNM1L Variant Alters Baseline Mitochondrial Function and Response to Stress in a Patient with Severe Neurological Dysfunction by Hogarth, Kaley A., Costford, Sheila R., Yoon, Grace, Sondheimer, Neal, Maynes, Jason T.

“…Mitochondria play vital roles in brain development and neuronal activity, and mitochondrial dynamics (fission and fusion) maintain organelle function through…”
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TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipid-induced inflammation and insulin resistance in muscle cells by Hussey, Sophie E, Liang, Hanyu, Costford, Sheila R, Klip, Amira, DeFronzo, Ralph A, Sanchez-Avila, Alicia, Ely, Brian, Musi, Nicolas

“…Emerging evidence suggests that TLR (Toll-like receptor) 4 and downstream pathways [MAPKs (mitogen-activated protein kinases) and NF-κB (nuclear factor κB)]…”
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Mice lacking NOX2 are hyperphagic and store fat preferentially in the liver by Costford, Sheila R, Castro-Alves, Jason, Chan, Kenny L, Bailey, Liane J, Woo, Minna, Belsham, Denise D, Brumell, John H, Klip, Amira

“…Chronic low-grade inflammation is an important contributor to the development of insulin resistance, a hallmark of type 2 diabetes mellitus (T2DM). Obesity and…”
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TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipidinduced inflammation and insulin resistance in muscle cells by Hussey, Sophie E., Liang, Hanyu, Costford, Sheila R., Klip, Amira, DeFronzo, Ralph A., Sanchez-Avila, Alicia, Ely, Brian, Musi, Nicolas

“…Emerging evidence suggests that TLR (Toll-like receptor) 4 and downstream pathways [MAPKs (mitogen-activated protein kinases) and NF-κB (nuclear factor κB)]…”
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Long-term high-fat feeding induces greater fat storage in mice lacking UCP3 by Costford, Sheila R, Chaudhry, Shehla N, Crawford, Sean A, Salkhordeh, Mahmoud, Harper, Mary-Ellen

“…Uncoupling protein-3 (UCP3) is a mitochondrial inner-membrane protein highly expressed in skeletal muscle. While UCP3's function is still unknown, it has been…”
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Differences in Mitochondrial Coupling Reveal a Novel Signature of Mitohormesis in Muscle of Healthy Individuals by Sparks, Lauren M, Redman, Leanne M, Conley, Kevin E, Harper, Mary-Ellen, Hodges, Andrew, Eroshkin, Alexey, Costford, Sheila R, Gabriel, Meghan E, Yi, Fanchao, Shook, Cherie, Cornnell, Heather H, Ravussin, Eric, Smith, Steven R

“…Context: Reduced mitochondrial coupling (ATP/O2 [P/O]) is associated with sedentariness and insulin resistance. Interpreting the physiological relevance of P/O…”
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Higher Mitochondrial Respiration and Uncoupling with Reduced Electron Transport Chain Content in Vivo in Muscle of Sedentary Versus Active Subjects by Conley, Kevin E, Amara, Catherine E, Bajpeyi, Sudip, Costford, Sheila R, Murray, Kori, Jubrias, Sharon A, Arakaki, Lori, Marcinek, David J, Smith, Steven R

“…Objective: This study investigated the disparity between muscle metabolic rate and mitochondrial metabolism in human muscle of sedentary vs. active…”
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Effects of the presence, absence, and overexpression of uncoupling protein-3 on adiposity and fuel metabolism in congenic mice by Costford, Sheila R, Chaudhry, Shehla N, Salkhordeh, Mahmoud, Harper, Mary-Ellen

“…Uncoupling protein-3 (UCP3) is a poorly understood mitochondrial inner membrane protein expressed predominantly in skeletal muscle. The aim of this study was…”
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Role of Skeletal Muscle Mitochondrial Density on Exercise-Stimulated Lipid Oxidation by Galgani, Jose E., Johannsen, Neil M., Bajpeyi, Sudip, Costford, Sheila R., Zhang, Zhengyu, Gupta, Alok K., Ravussin, Eric

“…Reduced skeletal muscle mitochondrial density is proposed to lead to impaired muscle lipid oxidation and increased lipid accumulation in sedentary individuals…”
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