Search Results - "Costford, S R"

Expression of anti-inflammatory macrophage genes within skeletal muscle correlates with insulin sensitivity in human obesity and type 2 diabetes by Fink, L. N., Oberbach, A., Costford, S. R., Chan, K. L., Sams, A., Blüher, M., Klip, A.

“…Aims/hypothesis Low-grade systemic inflammation and adipose tissue inflammatory macrophages are frequently detected in patients with obesity and type 2…”
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Increased susceptibility to oxidative damage in post-diabetic human myotubes by Costford, S. R, Crawford, S. A, Dent, R, McPherson, R, Harper, M.-E

“…Aims/hypothesis Obesity is an important risk factor for the development of type 2 diabetes, but not all obese individuals develop this complication. The…”
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Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)γ₃ results in increased oxidative capacity and glucose uptake in human primary myotubes by Crawford, S. A, Costford, S. R, Aguer, C, Thomas, S. C, deKemp, R. A, DaSilva, J. N, Lafontaine, D, Kendall, M, Dent, R, Beanlands, R. S. B, McPherson, R, Harper, M.-E

“…Aims/hypothesis AMP-activated protein kinase (AMPK) has a broad role in the regulation of glucose and lipid metabolism making it a promising target in the…”
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Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3) results in increased oxidative capacity and glucose uptake in human primary myotubes by Crawford, S A, Costford, S R, Aguer, C, Thomas, S C, deKemp, R A, DaSilva, J N, Lafontaine, D, Kendall, M, Dent, R, Beanlands, R S B, McPherson, R, Harper, M-E

“…AMP-activated protein kinase (AMPK) has a broad role in the regulation of glucose and lipid metabolism making it a promising target in the treatment of type 2…”
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Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)[gamma]3 results in increased oxidative capacity and glucose uptake in human primary myotubes by Crawford, S A, Costford, S R, Aguer, C, Thomas, S C, Dekemp, R A, Dasilva, J N, Lafontaine, D, Kendall, M, Dent, R, Beanlands, R S; B, Mcpherson, R, Harper, M-e

“…AMP-activated protein kinase (AMPK) has a broad role in the regulation of glucose and lipid metabolism making it a promising target in the treatment of type 2…”
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TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipidinduced inflammation and insulin resistance in muscle cells by Hussey, Sophie E., Liang, Hanyu, Costford, Sheila R., Klip, Amira, DeFronzo, Ralph A., Sanchez-Avila, Alicia, Ely, Brian, Musi, Nicolas

“…Emerging evidence suggests that TLR (Toll-like receptor) 4 and downstream pathways [MAPKs (mitogen-activated protein kinases) and NF-κB (nuclear factor κB)]…”
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Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)g sub(3) results in increased oxidative capacity and glucose uptake in human primary myotubes by Crawford, SA, Costford, SR, Aguer, C, Thomas, S C, deKemp, R A, DaSilva, J N, Lafontaine, D, Kendall, M, Dent, R, Beanlands, RSB, McPherson, R, Harper, M-E

“…Aims/hypothesis: AMP-activated protein kinase (AMPK) has a broad role in the regulation of glucose and lipid metabolism making it a promising target in the…”
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