Search Results - "Costes, V."

NASA GeneLab: interfaces for the exploration of space omics data by Berrios, Daniel C, Galazka, Jonathan, Grigorev, Kirill, Gebre, Samrawit, Costes, Sylvain V

“…Abstract The mission of NASA’s GeneLab database (https://genelab.nasa.gov/) is to collect, curate, and provide access to the genomic, transcriptomic, proteomic…”
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Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair by Chiolo, Irene, Minoda, Aki, Colmenares, Serafin U., Polyzos, Aris, Costes, Sylvain V., Karpen, Gary H.

“…Double-strand breaks (DSBs) in heterochromatic repetitive DNAs pose significant threats to genome integrity, but information about how such lesions are…”
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Central Nervous System Responses to Simulated Galactic Cosmic Rays by Cekanaviciute, Egle, Rosi, Susanna, Costes, Sylvain V

“…In preparation for lunar and Mars missions it is essential to consider the challenges to human health that are posed by long-duration deep space habitation via…”
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GeneLab: Omics database for spaceflight experiments by Ray, Shayoni, Gebre, Samrawit, Fogle, Homer, Berrios, Daniel C, Tran, Peter B, Galazka, Jonathan M, Costes, Sylvain V

“…Abstract Motivation To curate and organize expensive spaceflight experiments conducted aboard space stations and maximize the scientific return of investment,…”
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Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact by da Silveira, Willian A., Fazelinia, Hossein, Rosenthal, Sara Brin, Laiakis, Evagelia C., Kim, Man S., Meydan, Cem, Kidane, Yared, Rathi, Komal S., Smith, Scott M., Stear, Benjamin, Ying, Yue, Zhang, Yuanchao, Foox, Jonathan, Zanello, Susana, Crucian, Brian, Wang, Dong, Nugent, Adrienne, Costa, Helio A., Zwart, Sara R., Schrepfer, Sonja, Elworth, R.A. Leo, Sapoval, Nicolae, Treangen, Todd, MacKay, Matthew, Gokhale, Nandan S., Horner, Stacy M., Singh, Larry N., Wallace, Douglas C., Willey, Jeffrey S., Schisler, Jonathan C., Meller, Robert, McDonald, J. Tyson, Fisch, Kathleen M., Hardiman, Gary, Taylor, Deanne, Mason, Christopher E., Costes, Sylvain V., Beheshti, Afshin

“…Spaceflight is known to impose changes on human physiology with unknown molecular etiologies. To reveal these causes, we used a multi-omics, systems biology…”
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A microRNA signature and TGF-β1 response were identified as the key master regulators for spaceflight response by Beheshti, Afshin, Ray, Shayoni, Fogle, Homer, Berrios, Daniel, Costes, Sylvain V

“…Translating fundamental biological discoveries from NASA Space Biology program into health risk from space flights has been an ongoing challenge. We propose to…”
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Biological horizons: pioneering open science in the cosmos by Costes, Sylvain V., Gentemann, Chelle L., Platts, Steven H., Carnell, Lisa A.

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CPA: a web-based platform for consensus pathway analysis and interactive visualization by Nguyen, Hung, Tran, Duc, Galazka, Jonathan M, Costes, Sylvain V, Beheshti, Afshin, Petereit, Juli, Draghici, Sorin, Nguyen, Tin

“…Abstract In molecular biology and genetics, there is a large gap between the ease of data collection and our ability to extract knowledge from these data…”
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Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells by Neumaier, Teresa, Swenson, Joel, Pham, Christopher, Polyzos, Aris, Lo, Alvin T, Yang, PoAn, Dyball, Jane, Asaithamby, Aroumougame, Chen, David J, Bissell, Mina J, Thalhammer, Stefan, Costes, Sylvain V

“…The concept of DNA "repair centers" and the meaning of radiation-induced foci (RIF) in human cells have remained controversial. RIFs are characterized by the…”
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Automatic and Quantitative Measurement of Protein-Protein Colocalization in Live Cells by Costes, Sylvain V., Daelemans, Dirk, Cho, Edward H., Dobbin, Zachary, Pavlakis, George, Lockett, Stephen

“…We introduce a novel statistical approach that quantifies, for the first time, the amount of colocalization of two fluorescent-labeled proteins in an image…”
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Breast implant-associated anaplastic large cell lymphoma: two distinct clinicopathological variants with different outcomes by Laurent, C., Delas, A., Gaulard, P., Haioun, C., Moreau, A., Xerri, L., Traverse-Glehen, A., Rousset, T., Quintin-Roue, I., Petrella, T., Emile, J.F., Amara, N., Rochaix, P., Chenard-Neu, M.P., Tasei, A.M., Menet, E., Chomarat, H., Costes, V., Andrac-Meyer, L., Michiels, J.F., Chassagne-Clement, C., de Leval, L., Brousset, P., Delsol, G., Lamant, L.

“…ALK-negative anaplastic large cell lymphoma associated with breast implant (i-ALCL) has been recently recognized as a distinct entity. Among 43 830 lymphomas…”
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Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice by Masarapu, Yuvarani, Cekanaviciute, Egle, Andrusivova, Zaneta, Westholm, Jakub O., Björklund, Åsa, Fallegger, Robin, Badia-i-Mompel, Pau, Boyko, Valery, Vasisht, Shubha, Saravia-Butler, Amanda, Gebre, Samrawit, Lázár, Enikő, Graziano, Marta, Frapard, Solène, Hinshaw, Robert G., Bergmann, Olaf, Taylor, Deanne M., Wallace, Douglas C., Sylvén, Christer, Meletis, Konstantinos, Saez-Rodriguez, Julio, Galazka, Jonathan M., Costes, Sylvain V., Giacomello, Stefania

“…Impairment of the central nervous system (CNS) poses a significant health risk for astronauts during long-duration space missions. In this study, we employed…”
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Multi-omics analysis of multiple missions to space reveal a theme of lipid dysregulation in mouse liver by Beheshti, Afshin, Chakravarty, Kaushik, Fogle, Homer, Fazelinia, Hossein, Silveira, Willian A. da, Boyko, Valery, Polo, San-Huei Lai, Saravia-Butler, Amanda M., Hardiman, Gary, Taylor, Deanne, Galazka, Jonathan M., Costes, Sylvain V.

“…Spaceflight has several detrimental effects on the physiology of astronauts, many of which are recapitulated in rodent models. Mouse studies performed on the…”
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Dose, LET and Strain Dependence of Radiation-Induced 53BP1 Foci in 15 Mouse Strains Ex Vivo Introducing Novel DNA Damage Metrics by Penninckx, Sébastien, Cekanaviciute, Egle, Degorre, Charlotte, Guiet, Elodie, Viger, Louise, Lucasb, Stéphane, Costes, Sylvain V.

“…We present a comprehensive comparative analysis on the repair of radiation-induced DNA damage ex vivo in 15 strains of mice, including 5 inbred reference…”
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Astronaut omics and the impact of space on the human body at scale by Rutter, Lindsay A., Cope, Henry, MacKay, Matthew J., Herranz, Raúl, Das, Saswati, Ponomarev, Sergey A., Costes, Sylvain V., Paul, Amber M., Barker, Richard, Taylor, Deanne M., Bezdan, Daniela, Szewczyk, Nathaniel J., Muratani, Masafumi, Mason, Christopher E., Giacomello, Stefania

“…Future multi-year crewed planetary missions will motivate advances in aerospace nutrition and telehealth. On Earth, the Human Cell Atlas project aims to…”
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GeneLab Database Analyses Suggest Long-Term Impact of Space Radiation on the Cardiovascular System by the Activation of FYN Through Reactive Oxygen Species by Beheshti, Afshin, McDonald, J Tyson, Miller, Jack, Grabham, Peter, Costes, Sylvain V

“…Space radiation has recently been considered a risk factor for astronauts' cardiac health. As an example, for the case of how to query and identify datasets…”
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Nuclear dynamics of radiation-induced foci in euchromatin and heterochromatin by Chiolo, Irene, Tang, Jonathan, Georgescu, Walter, Costes, Sylvain V

“…Repair of double strand breaks (DSBs) is essential for cell survival and genome integrity. While much is known about the molecular mechanisms involved in DSB…”
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Salivary gland cancer: ESMO–European Reference Network on Rare Adult Solid Cancers (EURACAN) Clinical Practice Guideline for diagnosis, treatment and follow-up by van Herpen, C., Vander Poorten, V., Skalova, A., Terhaard, C., Maroldi, R., van Engen, A., Baujat, B., Locati, L.D., Jensen, A.D., Smeele, L., Hardillo, J., Martineau, V. Costes, Trama, A., Kinloch, E., Even, C., Machiels, J.-P.

“…•This ESMO–EURACAN Clinical Practice Guideline provides key recommendations for managing salivary gland cancer.•The guideline covers clinical and pathological…”
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Characterizing the DNA Damage Response by Cell Tracking Algorithms and Cell Features Classification Using High-Content Time-Lapse Analysis by Georgescu, Walter, Osseiran, Alma, Rojec, Maria, Liu, Yueyong, Bombrun, Maxime, Tang, Jonathan, Costes, Sylvain V

“…Traditionally, the kinetics of DNA repair have been estimated using immunocytochemistry by labeling proteins involved in the DNA damage response (DDR) with…”
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Advancing the Integration of Biosciences Data Sharing to Further Enable Space Exploration by Scott, Ryan T., Grigorev, Kirill, Mackintosh, Graham, Gebre, Samrawit G., Mason, Christopher E., Del Alto, Martha E., Costes, Sylvain V.

“…Understanding the impact of space exploration remains biologically elusive. Cell Press is dedicating this month to spaceflight (Afshinnekoo et al., 2020), with…”
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