Search Results - "Costello, C. L."

Altered metabolism and mitochondrial genome in prostate cancer by Dakubo, G D, Parr, R L, Costello, L C, Franklin, R B, Thayer, R E

“…Mutations in mitochondrial DNA are frequent in cancer and the accompanying mitochondrial dysfunction and altered intermediary metabolism might contribute to,…”
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Prostatic fluid electrolyte composition for the screening of prostate cancer: a potential solution to a major problem by Costello, L C, Franklin, R B

“…Early detection is the key to effective treatment of prostate cancer, and to the prevention of deaths due to progression to untreatable advanced stage cancer…”
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The intermediary metabolism of the prostate: a key to understanding the pathogenesis and progression of prostate malignancy by Costello, L C, Franklin, R B

“…This review emphasizes the importance and role of altered intermediary metabolism of prostate cells in the pathogenesis of prostate adenocarcinoma (PCa) and…”
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Mitochondrial function, zinc, and intermediary metabolism relationships in normal prostate and prostate cancer by Costello, L C, Franklin, R B, Feng, Pei

“…Human prostate secretory epithelial cells have the uniquely specialized function of accumulating and secreting extremely high levels of citrate. This is…”
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Novel role of zinc in the regulation of prostate citrate metabolism and its implications in prostate cancer by Costello, L.C., Franklin, R.B.

“…The prostate gland of humans and many other animals has the major function of accumulating and secreting extraordinarily high levels of citrate. This…”
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High frequency of pulmonary lymphangioleiomyomatosis in women with tuberous sclerosis complex by Costello, L C, Hartman, T E, Ryu, J H

“…To determine the frequency of pulmonary lymphangioleiomyomatosis (LAM), a rare cystic lung disorder that occurs almost exclusively in women of reproductive…”
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Role of zinc in the pathogenesis and treatment of prostate cancer: critical issues to resolve by Costello, L C, Feng, P, Milon, B, Tan, M, Franklin, R B

“…The most consistent and persistent biochemical characteristic of prostate cancer (PCa) is the marked decrease in zinc and citrate levels in the malignant…”
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Citrate in the diagnosis of prostate cancer by Costello, L.C., Franklin, R.B., Narayan, P.

“…BACKGROUND One of the major current problems involved in prostate cancer (PCa) is the unavailability of sensitive, accurate, and preferably noninvasive…”
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Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells by Franklin, R.B., Ma, J., Zou, J., Guan, Z., Kukoyi, B.I., Feng, P., Costello, L.C.

“…The prostate gland of humans and other animals accumulates a level of zinc that is 3–10 times greater than that found in other tissues. Associated with this…”
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Inhibitory effect of zinc on human prostatic carcinoma cell growth by Liang, Ji-Yong, Liu, Yi-Yan, Zou, Jing, Franklin, Renty B., Costello, Leslie C., Feng, Pei

“…BACKGROUND Normal human prostate accumulates the highest levels of zinc of any soft tissue in the body. In contrast, the zinc level in prostate cancer is…”
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Effect of prolactin on the prostate by Costello, L C, Franklin, R B

“…We propose that: 1. Prolactin is a trophic hormone required for normal development and growth of prostate as well as other tissues. 2. Citrate production, the…”
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Testosterone and prolactin regulation of metabolic genes and citrate metabolism of prostate epithelial cells by Costello, L C, Franklin, R B

“…The control and alteration of key regulatory enzymes is a determinant of the reactions and pathways of intermediary metabolism in mammalian cells. An important…”
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Citrate metabolism of normal and malignant prostate epithelial cells by Costello, Leslie C., Franklin, Renty B.

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Prolactin and testosterone regulation of mitochondrial zinc in prostate epithelial cells by Liu, Y., Franklin, R.B., Costello, L.C.

“…The prostate gland of many animals accumulates extremely high levels of zinc and citrate. Evidence currently exists in support of a concept that zinc might be…”
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P947: COMPARATIVE EFFECTIVENESS OF ORAL IXAZOMIB‐LENALIDOMIDE‐DEXAMETHASONE (IRD) AFTER INITIAL BORTEZOMIB (V)‐BASED INDUCTION VS PARENTERAL V‐BASED THERAPY IN NEWLY DIAGNOSED MULTIPLE MYELOMA (NDMM) by Rifkin, R. M., Costello, C. L., Birhiray, R. E., Kambhampati, S., Richter, J., Abonour, R., Lee, H. C., Kim, Y. J., Ren, K., Stull, D. M., Cherepanov, D., Bogard, K., Noga, S. J., Girnius, S.

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Inositol acylation of a potential glycosyl phosphoinositol anchor precursor from yeast requires acyl coenzyme A by COSTELLO, L. C, ORLEAN, P

“…Glycosyl phosphoinositol (GPI) anchors on proteins can be modified by palmitoylation of their inositol residue, which makes such anchors resistant to cleavage…”
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Bioenergetic theory of prostate malignancy by Costello, L C, Franklin, R B

“…Normal and benign prostate hyperplasia (BPH) prostate is characterized by the presence of extraordinarily high levels of citrate. Presumably, this results from…”
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Concepts of citrate production and secretion by prostate: 2. Hormonal relationships in normal and neoplastic prostate by Costello, L C, Franklin, R B

“…A unique and major function of prostate secretory epithelial cells is to synthesize, accumulate, and secrete extraordinarily high levels of citrate. This…”
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Mitochondrial aconitase gene expression is regulated by testosterone and prolactin in prostate epithelial cells by Costello, L.C., Liu, Y., Zou, J., Franklin, R.B.

“…BACKGROUND m‐aconitase catalyzes the first step leading to the oxidation of citrate via the Krebs cycle. It is a constituitive enzyme in virtually all…”
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Testosterone and prolactin stimulation of mitochondrial aconitase in pig prostate epithelial cells by COSTELLO, L. C, LIU, Y, FRANKLIN, R. B

“…The function of the prostate gland in many animals, including humans, is to accumulate and secrete large quantities of citrate. This function derives from the…”
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