Search Results - "Costell, Melissa H"

Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress by Costell, Melissa H, Ancellin, Nicolas, Bernard, Roberta E, Zhao, Shufang, Upson, John J, Morgan, Lisa A, Maniscalco, Kristeen, Olzinski, Alan R, Ballard, Victoria L T, Herry, Kenny, Grondin, Pascal, Dodic, Nerina, Mirguet, Olivier, Bouillot, Anne, Gellibert, Francoise, Coatney, Robert W, Lepore, John J, Jucker, Beat M, Jolivette, Larry J, Willette, Robert N, Schnackenberg, Christine G, Behm, David J

“…Soluble guanylate cyclase (sGC), the primary mediator of nitric oxide (NO) bioactivity, exists as reduced (NO-sensitive) and oxidized (NO-insensitive) forms…”
Get full text

Evaluation of GSK2789917-induced TRPV4 inhibition in animal models of fluid induced lung injury by Bihari, Shailesh, Costell, Melissa H., Bouchier, Tara, Behm, David J., Burgert, Mark, Ye, Guosen, Bersten, Andrew D., Puukila, Stephanie, Cavallaro, Elena, Sprecher, Dennis L., Dixon, Dani-Louise

“…Administration of bolus intravenous fluids, common in pre-hospital and hospitalised patients, is associated with increased lung vascular permeability and…”
Get full text

Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid‑4 (TRPV4) by Brnardic, Edward J, Ye, Guosen, Brooks, Carl, Donatelli, Carla, Barton, Linda, McAtee, Jeff, Sanchez, Robert M, Shu, Arthur, Erhard, Karl, Terrell, Lamont, Graczyk-Millbrandt, Grazyna, He, Yanan, Costell, Melissa H, Behm, David J, Roethke, Theresa, Stoy, Patrick, Holt, Dennis A, Lawhorn, Brian G

“…A novel series of pyrrolidine sulfonamide transient receptor potential vanilloid-4 (TRPV4) antagonists was developed by modification of a previously reported…”
Get full text

Identification of a Human Whole Blood-Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo by Xu, Xiaoping, Goyal, Navin, Costell, Melissa H, Roethke, Theresa, James, Christian H, Thorneloe, Kevin S, Patterson, Jaclyn, Stoy, Patrick, Goodman, Krista, Sprecher, Dennis L, Behm, David J

“…Transient receptor potential vanilloid 4 (TRPV4) channels expressed on pulmonary endothelial cells are activated by elevated pulmonary vascular pressure,…”
Get full text

Discovery of GSK3527497: A Candidate for the Inhibition of Transient Receptor Potential Vanilloid‑4 (TRPV4) by Brooks, Carl A, Barton, Linda S, Behm, David J, Brnardic, Edward J, Costell, Melissa H, Holt, Dennis A, Jolivette, Larry J, Matthews, Jay M, McAtee, John J, McCleland, Brent W, Patterson, Jaclyn R, Pero, Joseph E, Rivero, Ralph A, Roethke, Theresa J, Sanchez, Robert M, Shenje, Raynold, Terrell, Lamont R, Lawhorn, Brian G

“…GSK3527497, a preclinical candidate for the inhibition of TRPV4, was identified starting from the previously reported pyrrolidine sulfonamide TRPV4 inhibitors…”
Get full text

Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid‑4 with in Vivo Activity in a Pulmonary Edema Model by Pero, Joseph E, Matthews, Jay M, Behm, David J, Brnardic, Edward J, Brooks, Carl, Budzik, Brian W, Costell, Melissa H, Donatelli, Carla A, Eisennagel, Stephen H, Erhard, Karl, Fischer, Michael C, Holt, Dennis A, Jolivette, Larry J, Li, Huijie, Li, Peng, McAtee, John J, McCleland, Brent W, Pendrak, Israil, Posobiec, Lorraine M, Rivera, Katrina L.K, Rivero, Ralph A, Roethke, Theresa J, Sender, Matthew R, Shu, Arthur, Terrell, Lamont R, Vaidya, Kalindi, Xu, Xiaoping, Lawhorn, Brian G

“…Pulmonary edema is a common ailment of heart failure patients and has remained an unmet medical need due to dose-limiting side effects associated with current…”
Get full text

Chronic Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity Decreases Hypertension, Insulin Resistance, and Hypertriglyceridemia in Metabolic Syndrome by Yue, Tian-Li, Willette, Robert N., Hong, Victor S., Wu, Charlene W., Cui, Jianqi, Krosky, Daniel J., Costell, Melissa H., Schnackenberg, Christine G., Harpel, Mark R.

“…Metabolic syndrome is a constellation of risk factors including hypertension, dyslipidemia, insulin resistance, and obesity that promote the development of…”
Get full text

Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase by Thalji, Reema K., McAtee, Jeff J., Belyanskaya, Svetlana, Brandt, Martin, Brown, Gregory D., Costell, Melissa H., Ding, Yun, Dodson, Jason W., Eisennagel, Steve H., Fries, Rusty E., Gross, Jeffrey W., Harpel, Mark R., Holt, Dennis A., Israel, David I., Jolivette, Larry J., Krosky, Daniel, Li, Hu, Lu, Quinn, Mandichak, Tracy, Roethke, Theresa, Schnackenberg, Christine G., Schwartz, Benjamin, Shewchuk, Lisa M., Xie, Wensheng, Behm, David J., Douglas, Stephen A., Shaw, Ami L., Marino, Joseph P.

“…1-(1,3,5-Triazin-yl)piperidine-4-carboxamide inhibitors of soluble epoxide hydrolase were identified from high through-put screening using encoded library…”
Get full text

Modulation of transient receptor potential canonical channel 3 (TRPC3) activity by a novel pharmacological agonist and antagonist in normotensive and hypertensive rats by Schnackenberg, Christine G, Costell, Melissa H, Bernard, Roberta E, Xu, Xiaoping, Washburn, David G, Manns, Sharada, Marino, Joseph P

“…Abstract only Transient receptor potential canonical channel 3 (TRPC3) is a nonselective cation channel that is associated with hypertension. Previous studies…”
Get full text

Sodium and water homeostasis is maintained in rats with chronic TRPV4 blockade by Costell, Melissa H., Bernard, Roberta E., McCafferty, Gerald P., Roethke, Theresa J., Jolivette, Larry J., Willette, Robert N., Cheung, Mui, Thorneloe, Kevin S., Schnackenberg, Christine G.

“…The transient receptor potential vanilloid 4 (TRPV4) is a non‐selective cation channel that highly expressed in renal tubules. Co‐localization of TRPV4 with…”
Get full text

Activation of nitric oxide (NO)‐insensitive soluble guanylate cyclase does not provide greater benefit than NO‐sensitive stimulation in acute and chronic models of cardiovascular disease associated with oxidative stress by Costell, Melissa H., Bernard, Roberta E., Alsaid, Hasan, Upson, John J., Olzinski, Alan R., Morgan, Lisa A., Grondin, Pascal O., Ancellin, Nicolas, Dodic, Nerina, Gellibert, Francoise, Jucker, Beat M., Jolivette, Larry J., Willette, Robert N., Schnackenberg, Christine G., Behm, David J.

“…Soluble guanylate cyclase (sGC), the primary mediator of nitric oxide (NO), exists as reduced (NO‐sensitive) and oxidized (NO‐insensitive) forms. Because…”
Get full text

Serum and glucocorticoid‐regulated kinase mediates hypertension and end organ damage in DOCA‐salt hypertension by Schnackenberg, Christine G., Costell, Melissa H., Hoang, Bao, Duddy, Graham, Willette, Robert N.

“…Abstract only Serum and glucocorticoid‐regulated kinase 1 (SGK1) plays an important role in mediating mineralocorticoid receptor stimulated sodium…”
Get full text

Suppression of 11beta-hydroxysteroid dehydrogenase type 1 activity diminish insulin resistance and hypertriglyceridemia in metabolic syndrome by Cui, Jianqi, Schnackenberg, Christine G., Costell, Melissa H., Krosky, Daniel J., Wu, Charlene W., Hong, Victor S., Harpel, Mark R., Willette, Robert N., Yue, Tian‑Li

Get full text

Chronic inhibition of 11beta‐hydroxysteroid dehydrogenase activity reduces cardiovascular comorbidities in corpulent and stroke‐prone SHR by Schnackenberg, Christine G., Costell, Melissa H., Eybye, Marianne E., Cui, Jianqi, Maniscalco, Kristeen, Bentley, Ross, Willette, Robert N., Yue, Tian‐Li, Doe, Chris P.

“…Abstract only Changes in the secretion or metabolism of cortisol are associated with human hypertension and metabolic disorders. 11beta‐hydroxysteroid…”
Get full text

Compensatory role for Sgk2 mediated sodium reabsorption during salt deprivation in Sgk1 knockout mice by Schnackenberg, Christine G, Costell, Melissa H., Bernard, Roberta E., Minuti, Kristine K., Grygielko, Eugene T., Parsons, Michael J., Laping, Nicholas J., Duddy, Graham

“…The purpose of this study was to investigate the role of Sgk2 in the regulation of salt and water homeostasis. Kidney function and expression of Sgk1, Sgk2,…”
Get full text