Search Results - "Costantino, Luca"

Privileged structures as leads in medicinal chemistry by Costantino, Luca, Barlocco, Daniela

“…Among the strategies that can lead to the discovery of new drugs, the identification and use of privileged structures, molecular fragments that are able to…”
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STAT 3 as a target for cancer drug discovery by Costantino, Luca, Barlocco, Daniela

“…Stat-3 (Signal Transduction and Activator of Transcription) is a member of the Stat family of latent, cytosolic transcription factors that directly relate…”
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Iron Acquisition Pathways as Targets for Antitubercular Drugs by Meneghetti, Fiorella, Villa, Stefania, Gelain, Arianna, Barlocco, Daniela, Chiarelli, Laurent Roberto, Pasca, Maria Rosalia, Costantino, Luca

“…Tuberculosis nowadays ranks as the second leading cause of death from an infectious disease worldwide. In the last twenty years, this disease has again started…”
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Nose-to-brain drug delivery by nanoparticles in the treatment of neurological disorders by Ong, Wei-Yi, Shalini, Suku-Maran, Costantino, Luca

“…Many potential drugs for the treatment of neurological diseases are unable to reach the brain in sufficient enough concentrations to be therapeutic because of…”
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New Chromane-Based Derivatives as Inhibitors of Mycobacterium tuberculosis Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies by Pini, Elena, Poli, Giulio, Tuccinardi, Tiziano, Chiarelli, Laurent Roberto, Mori, Matteo, Gelain, Arianna, Costantino, Luca, Villa, Stefania, Meneghetti, Fiorella, Barlocco, Daniela

“…Tuberculosis is the leading cause of death from a single infectious agent worldwide; therefore, the need for new antitubercular drugs is desperate. The…”
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Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution by Vergoni, Anna Valeria, MD, Tosi, Giovanni, PhD, Tacchi, Raffaella, MD, Vandelli, Maria Angela, PhD, Bertolini, Alfio, MD, Costantino, Luca, PhD

“…Abstract The pharmacological treatment of neurological disorders is often complicated by the inability of drugs to pass the blood-brain barrier. Recently we…”
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In Vivo Biodistribution of Respirable Solid Lipid Nanoparticles Surface-Decorated with a Mannose-Based Surfactant: A Promising Tool for Pulmonary Tuberculosis Treatment? by Truzzi, Eleonora, Nascimento, Thais Leite, Iannuccelli, Valentina, Costantino, Luca, Lima, Eliana Martins, Leo, Eliana, Siligardi, Cristina, Gualtieri, Magdalena Lassinantti, Maretti, Eleonora

“…The active targeting to alveolar macrophages (AM) is an attractive strategy to improve the therapeutic efficacy of 'old' drugs currently used in clinical…”
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New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents by Chiarelli, Laurent R., Mori, Matteo, Beretta, Giangiacomo, Gelain, Arianna, Pini, Elena, Sammartino, Josè Camilla, Stelitano, Giovanni, Barlocco, Daniela, Costantino, Luca, Lapillo, Margherita, Poli, Giulio, Caligiuri, Isabella, Rizzolio, Flavio, Bellinzoni, Marco, Tuccinardi, Tiziano, Villa, Stefania, Meneghetti, Fiorella

“…Starting from the analysis of the hypothetical binding mode of our previous furan-based hit (I), we successfully achieved our objective to replace the nitro…”
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Soft Docking and Multiple Receptor Conformations in Virtual Screening by Ferrari, Anna Maria, Wei, Binqing Q, Costantino, Luca, Shoichet, Brian K

“…Protein conformational change is an important consideration in ligand-docking screens, but it is difficult to predict. A simple way to account for protein…”
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Current and Future Chemotherapy for Chagas Disease by Gaspar, Luís, Moraes, Carolina B, Freitas-Junior, Lucio H, Ferrari, Stefania, Costantino, Luca, Costi, Maria Paola, Coron, Ross P, Smith, Terry K, Siqueira-Neto, Jair L, McKerrow, James H, Cordeiro-da-Silva, Anabela

“…Human American trypanosomiasis, commonly called Chagas disease, is one of the most neglected illnesses in the world and remains one of the most prevalent…”
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The Impact of Lipid Corona on Rifampicin Intramacrophagic Transport Using Inhaled Solid Lipid Nanoparticles Surface-Decorated with a Mannosylated Surfactant by Maretti, Eleonora, Rustichelli, Cecilia, Lassinantti Gualtieri, Magdalena, Costantino, Luca, Siligardi, Cristina, Miselli, Paola, Buttini, Francesca, Montecchi, Monica, Leo, Eliana, Truzzi, Eleonora, Iannuccelli, Valentina

“…The mimicking of physiological conditions is crucial for the success of accurate in vitro studies. For inhaled nanoparticles, which are designed for being…”
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Ruptured Thoracoabdominal Aneurysm Treatment With Modified Chimney Stent Graft by Marino, Mario, MD, Kasemi, Holta, MD, Di Angelo, Costantino Luca, MD, Fadda, Gian Franco, MD

“…A 76-year-old woman presented with symptomatic contained-ruptured thoracoabdominal aneurysm at the level of the superior mesenteric artery (SMA) and the…”
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Is there a clinical future for polymeric nanoparticles as brain-targeting drug delivery agents? by Costantino, Luca, Boraschi, Diana

“…Injectable nanosized carriers (5–250nm) are actively studied as anticancer drug delivery agents for targeted drug delivery to the brain. Among these, polymeric…”
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Teaching an Undergraduate Organic Chemistry Laboratory Course with a Tailored Problem-Based Learning Approach by Costantino, Luca, Barlocco, Daniela

“…This article presents the structure of the organic chemistry laboratory Course “Synthesis and Extraction of Drugs” that is included in Modena University…”
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Inhibitors for proteins endowed with catalytic and non-catalytic activity which recognize pTyr by Costantino, Luca, Barlocco, Daniela

“…Reversible phosphorylation of Tyr residues in proteins plays a central role in the transduction of signals. For both SH2 domains and for protein tyrosine…”
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Ten Years of Medicinal Chemistry (2005–2014) in the Journal of Medicinal Chemistry: Country of Contributors, Topics, and Public–Private Partnerships: Miniperspective by Costantino, Luca, Barlocco, Daniela

“…This review analyzes the articles that have appeared during the past 10 years in the Journal of Medicinal Chemistry, the leading journal in the field of…”
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Interaction of nanoparticles with immunocompetent cells: nanosafety considerations by Boraschi, Diana, Costantino, Luca, Italiani, Paola

“…Intentional delivery of high doses of nanoparticle-based drugs or diagnostic/imaging systems sets a new scenario in safety evaluation, compared with the…”
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Synthesis, Activity, and Molecular Modeling of a New Series of Tricyclic Pyridazinones as Selective Aldose Reductase Inhibitors by Costantino, Luca, Rastelli, Giulio, Vescovini, Katia, Cignarella, Giorgio, Vianello, Paola, Del Corso, Antonella, Cappiello, Mario, Mura, Umberto, Barlocco, Daniela

“…Three new series of tricyclic pyridazinones have been synthesized and tested in vitro in order to assess (i) their ability to inhibit aldose reductase enzyme…”
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Growth hormone secretagogue receptor antagonists by Costantino, Luca

“…The patent claims peptidic/nonpeptidic inhibitors of the ghrelin receptor, the growth hormone secretagogue receptor (GHSR) 1A. Among these compounds, it was…”
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Surface engineering of Solid Lipid Nanoparticle assemblies by methyl α-d-mannopyranoside for the active targeting to macrophages in anti-tuberculosis inhalation therapy by Maretti, Eleonora, Costantino, Luca, Rustichelli, Cecilia, Leo, Eliana, Croce, Maria Antonietta, Buttini, Francesca, Truzzi, Eleonora, Iannuccelli, Valentina

“…[Display omitted] •Mannosylated SLN assemblies (SLNas) were investigated for inhaled anti-TB therapy.•Mannose residues were detected on SLNas…”
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