Search Results - "Costantino, L"

Aerosol indirect effect on warm clouds over South-East Atlantic, from co-located MODIS and CALIPSO observations by Costantino, L, Bréon, F.-M

“…In this study, we provide a comprehensive analysis of aerosol interaction with warm boundary layer clouds over the South-East Atlantic. We use aerosol and…”
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Pathophysiogenesis of mesial temporal lobe epilepsy: is prevention of damage antiepileptogenic? by Curia, G, Lucchi, C, Vinet, J, Gualtieri, F, Marinelli, C, Torsello, A, Costantino, L, Biagini, G

“…Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis, possibly caused by a primary brain injury that occurred a long time before…”
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Designed multiple ligands: basic research vs clinical outcomes by Costantino, L, Barlocco, D

“…The clinical treatment of multifactorial pathologies (e.g. cancer, Alzheimer's disease, psychiatric disorders), is still a major challenge. Many researches…”
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Carinal surgery: A single-institution experience spanning 2 decades by Costantino, Christina L., Geller, Abraham D., Wright, Cameron D., Ott, Harald C., Muniappan, Ashok, Mathisen, Douglas J., Lanuti, Michael

“…Complete resection of neoplasms involving the carina are technically challenging and have high operative morbidity and mortality. This study examines the last…”
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Tropical deep convection and density current signature in surface pressure: comparison between WRF model simulations and infrasound measurements by Costantino, L, Heinrich, P

“…Deep convection is a major atmospheric transport process in the tropics, affecting the global weather and the climate system. In the framework of the ARISE…”
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The Role of HuR in Gemcitabine Efficacy in Pancreatic Cancer: HuR Up-regulates the Expression of the Gemcitabine Metabolizing Enzyme Deoxycytidine Kinase by COSTANTINO, Christina L, WITKIEWICZ, Agnieszka K, KUWANO, Yuki, COZZITORTO, Joseph A, KENNEDY, Eugene P, DASGUPTA, Abhijit, KEEN, Judith C, YEO, Charles J, GOROSPE, Myriam, BRODY, Jonathan R

“…RNA-binding protein HuR binds U- or AU-rich sequences in the 3'-untranslated regions of target mRNAs, stabilizing them and/or modulating their translation…”
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Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival by Brody, Jonathan R., Costantino, Christina L., Berger, Adam C., Sato, Takami, Lisanti, Michael P., Yeo, Charles J., Emmons, Robert V., Witkiewicz, Agnieszka K.

“…The mechanism by which malignant melanoma (MM) cells survive in lymph nodes is poorly understood. One possible mechanism by which MM cells can escape immune…”
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Genotyping and Expression Analysis of IDO2 in Human Pancreatic Cancer: A Novel, Active Target by Witkiewicz, Agnieszka K., MD, Costantino, Christina L., BA, Metz, Richard, PhD, Muller, Alexander J., PhD, Prendergast, George C., PhD, Yeo, Charles J., MD, FACS, Brody, Jonathan R., PhD

“…Background The recently discovered indoleamine 2,3-dioxygenase-2 ( IDO2 ) gene has 2 functional polymorphisms that abolish its enzymatic activity. We…”
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Challenges in the design of clinically useful brain-targeted drug nanocarriers by Costantino, L, Boraschi, D, Eaton, M

“…Nowadays, the delivery of drugs by means of intravenously administered nanosized drug carriers - polymerdrug conjugates, liposomes and micelles, is technically…”
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Targeting the central nervous system: In vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123 by Tosi, G., Costantino, L., Rivasi, F., Ruozi, B., Leo, E., Vergoni, A.V., Tacchi, R., Bertolini, A., Vandelli, M.A., Forni, F.

“…Polymeric nanoparticles (Np) represent one of the most innovative non-invasive approaches for the drug delivery to the central nervous system (CNS). It is…”
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Convective gravity wave propagation and breaking in the stratosphere: comparison between WRF model simulations and lidar data by Costantino, L., Heinrich, P., Mzé, N., Hauchecorne, A.

“…In this work we perform numerical simulations of convective gravity waves (GWs), using the WRF (Weather Research and Forecasting) model. We first run an…”
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Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution by Tosi, G., Vergoni, A.V., Ruozi, B., Bondioli, L., Badiali, L., Rivasi, F., Costantino, L., Forni, F., Vandelli, M.A.

“…Polymeric nanoparticles (Np) have been considered as strategic carriers for brain targeting. Specific ligands on the surface allowed the Np to cross the…”
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Diagnostic application of a capture based NGS test for the concurrent detection of variants in sequence and copy number as well as LOH by Vetro, A., Goidin, D., Lesende, I., Limongelli, I., Ranzani, G.N., Novara, F., Bonaglia, M.C., Rinaldi, B., Franchi, F., Manolakos, E., Lonardo, F., Scarano, F., Scarano, G., Costantino, L., Tedeschi, S., Giglio, S., Zuffardi, O.

“…Whole exome sequencing (WES) has made the identification of causative SNVs/InDels associated with rare Mendelian conditions increasingly accessible…”
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Aortic aneurysm endovascular treatment with the parallel graft technique from the aortic arch to the iliac axis by Fadda, Gian Franco, Marino, Mario, Kasemi, Holta, Di Angelo, Costantino L, Dionisi, Carlo P, Cammalleri, Valeria, Setacci, Carlo

“…The chimney technique has been developed for the treatment of complex aortic aneurysms. We analyzed the midterm to long-term outcomes of this approach from a…”
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A Computational Tool for the Microstructure Optimization of a Polymeric Heart Valve Prosthesis by Serrani, M, Brubert, J, Stasiak, J, De Gaetano, F, Zaffora, A, Costantino, M L, Moggridge, G D

“…Styrene-based block copolymers are promising materials for the development of a polymeric heart valve prosthesis (PHV), and the mechanical properties of these…”
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Synthesis and aldose reductase inhibitory activity of 5-arylidene-2,4-thiazolidinediones by Bruno, G, Costantino, L, Curinga, C, Maccari, R, Monforte, F, Nicolò, F, Ottanà, R, Vigorita, M.G

“…Several (Z)-5-arylidene-2,4-thiazolidinediones were synthesized and tested as aldose reductase inhibitors (ARIs). The most active of the N-unsubstituted…”
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Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells by Hostetter, Christine, Licata, Lauren A., Costantino, Christina L., Witkiewicz, Agnes, Yeo, Charles, Brody, Jonathan R, Keen, Judith Clancy

“…With prolonged exposure, a majority of estrogen receptor positive cancers develop resistance to tamoxifen and subsequent therapies including selective estrogen…”
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Valproic acid restores ERα and antiestrogen sensitivity to ERα-negative breast cancer cells by Fortunati, N., Bertino, S., Costantino, L., De Bortoli, M., Compagnone, A., Bandino, A., Catalano, M.G., Boccuzzi, G.

“…Histone deacetylase inhibitors (HDIs) are valuable drugs in breast cancer where estrogen receptor α (ERα) can be silenced by epigenetic modifications. We…”
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Nanoparticulate drug carriers based on hybrid poly( d,l-lactide- co-glycolide)-dendron structures by Costantino, Luca, Gandolfi, Francesca, Bossy-Nobs, Leila, Tosi, Giovanni, Gurny, Robert, Rivasi, Francesco, Angela Vandelli, Maria, Forni, Flavio

“…We describe a general method for incorporating target moieties in a well-defined arrangement into the surface of biocompatible polyester poly( d,l-lactic-…”
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Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathway by Showalter, Shayna L, Wang, Ziqiu, Costantino, Christina L, Witkiewicz, Agnieszka K, Yeo, Charles J, Brody, Jonathan R, Carr, Brian I

“…Background and Aims:  Available medical therapies against pancreatic cancer are largely ineffective and have many side‐effects. Physiologically, vitamins K1…”
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