Search Results - "Costantino, H R"

Effect of excipients on the stability and structure of lyophilized recombinant human growth hormone by Costantino, H R, Carrasquillo, K G, Cordero, R A, Mumenthaler, M, Hsu, C C, Griebenow, K

“…We have investigated the effect of mannitol, sorbitol, methyl alpha-D-mannopyranoside, lactose, trehalose, and cellobiose on the stability and structure of the…”
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The effect of formulation excipients on protein stability and aerosol performance of spray-dried powders of a recombinant humanized anti-IgE monoclonal antibody by ANDYA, J. D, MAA, Y.-F, COSTANTINO, H. R, NGUYEN, P.-A, DASOVICH, N, SWEENEY, T. D, HSU, C. C, SHIRE, S. J

“…To study the effect of trehalose, lactose, and mannitol on the biochemical stability and aerosol performance of spray-dried powders of an anti-IgE humanized…”
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Effect of mannitol crystallization on the stability and aerosol performance of a spray-dried pharmaceutical protein, recombinant humanized anti-IgE monoclonal antibody by Costantino, H R, Andya, J D, Nguyen, P A, Dasovich, N, Sweeney, T D, Shire, S J, Hsu, C C, Maa, Y F

“…We have examined the stability and aerosol performance of the pharmaceutical protein recombinant humanized anti-IgE monoclonal antibody (rhuMAbE25) spray dried…”
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Solid-phase aggregation of proteins under pharmaceutically relevant conditions by Costantino, H R, Langer, R, Klibanov, A M

“…In order to successfully employ proteins as pharmaceuticals, it is essential to understand mechanistically the stability issues relevant to their formulation…”
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Moisture-induced aggregation of lyophilized insulin by COSTANTINO, H. R, LANGER, R, KLIBANOV, A. M

“…A critical problem in the storage and delivery of pharmaceutical proteins is aggregation in the solid state induced by elevated temperature and moisture. These…”
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Stabilization of Tetanus and Diphtheria Toxoids Against Moisture-Induced Aggregation by Schwendeman, Steven P., Costantino, Henry R., Gupta, Rajesh K., Siber, George R., Klibanov, Alexander M., Langer, Robert

“…The progress toward single-dose vaccines has been limited by the poor solid-state stability of vaccine antigens within controlled-release polymers, such as…”
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On the pH memory of lyophilized compounds containing protein functional groups by Costantino, Henry R., Griebenow, Kai, Langer, Robert, Klibanov, Alexander M.

“…Lyophilized proteins exhibit “pH memory,” i.e., their behavior in the solid form corresponds to the pH of the aqueous solution from which they were freeze…”
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Aggregation of a Lyophilized Pharmaceutical Protein, Recombinant Human Albumin: Effect of Moisture and Stabilization by Excipients by Costantino, Henry R, Langer, Robert, Klibanov, Alexander M

“…In the presence of water vapor at 37 degrees C, lyophilized recombinant human albumin (rHA) undergoes intermolecular thiol-disulfide interchange, eventually…”
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Determining the water sorption monolayer of lyophilized pharmaceutical proteins by Costantino, H R, Curley, J G, Hsu, C C

“…The concept of monolayer water coverage is useful in the development of lyophilized protein formulations. Herein, we have explored three different…”
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On the structural preservation of recombinant human growth hormone in a dried film of a synthetic biodegradable polymer by Carrasquillo, K G, Costantino, H R, Cordero, R A, Hsu, C C, Griebenow, K

“…In this work we describe the structural investigation of the model protein recombinant human growth hormone (rhGH) under conditions relevant to polymeric…”
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The secondary structure and aggregation of lyophilized tetanus toxoid by Costantino, H R, Schwendeman, S P, Griebenow, K, Klibanov, A M, Langer, R

“…Tetanus toxoid (TT), the vaccine for tetanus, is an important protein antigen and candidate for sustained release from polymeric matrices. During…”
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Deterioration of lyophilized pharmaceutical proteins by Costantino, H R, Schwendeman, S P, Langer, R, Klibanov, A M

“…The successful use of proteins in pharmaceutical and other commercial applications requires close examination of their relative fragility. Because of the…”
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Influence of calcium ions on the structure and stability of recombinant human deoxyribonuclease I in the aqueous and lyophilized states by Chen, B, Costantino, H R, Liu, J, Hsu, C C, Shire, S J

“…The effect of calcium ions on the structure and stability of recombinant human DNase I (rhDNase) in the aqueous and solid (lyophilized) states was…”
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Recent trends in stabilizing protein structure upon encapsulation and release from bioerodible polymers by Pérez, Caroline, Castellanos, Ingrid J., Costantino, Henry R., Al-Azzam, Wasfi, Griebenow, Kai

“…Sustained release of pharmaceutical proteins from biocompatible polymers offers new opportunities in the treatment and prevention of disease. The manufacturing…”
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Characterization of Amylolytic Enzyme Activities Associated with the Hyperthermophilic Archaebacterium Pyrococcus furiosus by Brown, S H, Costantino, H R, Kelly, R M

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Non-aqueous encapsulation of excipient-stabilized spray-freeze dried BSA into poly(lactide- co-glycolide) microspheres results in release of native protein by Carrasquillo, Karen G, Stanley, Ann M, Aponte-Carro, Juan C, De Jésus, Patricia, Costantino, Henry R, Bosques, Carlos J, Griebenow, Kai

“…Encapsulation of the model protein bovine serum albumin (BSA) into poly( d, l lactide- co-glycolide) (PLG) microspheres was performed by a non-aqueous…”
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Protein spray-freeze drying. Effect of atomization conditions on particle size and stability by COSTANTINO, Henry R, FIROUZABADIAN, Laleh, HOGELAND, Ken, CHICHIH WU, BEGANSKI, Chris, CARRASQUILLO, Karen G, CORDOVA, Melissa, GRIEBENOW, Kai, ZALE, Stephen E, TRACY, Mark A

“…To investigate the effect of atomization conditions on particle size and stability of spray-freeze dried protein. Atomization variables were explored for…”
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Preparation of excipient-free recombinant human tissue-type plasminogen activator by lyophilization from ammonium bicarbonate solution: an investigation of the two-stage sublimation phenomenon by Overcashier, D E, Brooks, D A, Costantino, H R, Hsu, C C

“…Dry, excipient-free recombinant human tissue-type plasminogen activator (tPA) powder was prepared by lyophilization from ammonium bicarbonate solution…”
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A novel injectable approach for cartilage formation in vivo using PLG microspheres by Mercier, Nichole R, Costantino, Henry R, Tracy, Mark A, Bonassar, Lawrence J

“…This study documents the use of biodegradable poly(lactide-co-glycolide) (PLG) microspheres as a novel, injectable scaffold for cartilage tissue engineering…”
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Purification and characterization of an α-glucosidase from a hyperthermophilic archaebacterium, Pyrococcus furiosus, exhibiting a temperature optimum of 105 to 115°C by COSTANTINO, H. R, BROWN, S. H, KELLY, R. M

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