Search Results - "Costantini, Paola"

Overview of the Maturation Machinery of the H-Cluster of [FeFe]-Hydrogenases with a Focus on HydF by Bortolus, Marco, Costantini, Paola, Doni, Davide, Carbonera, Donatella

“…Hydrogen production in nature is performed by hydrogenases. Among them, [FeFe]-hydrogenases have a peculiar active site, named H-cluster, that is made of two…”
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Human frataxin, the Friedreich ataxia deficient protein, interacts with mitochondrial respiratory chain by Doni, Davide, Cavion, Federica, Bortolus, Marco, Baschiera, Elisa, Muccioli, Silvia, Tombesi, Giulia, d’Ettorre, Federica, Ottaviani, Daniele, Marchesan, Elena, Leanza, Luigi, Greggio, Elisa, Ziviani, Elena, Russo, Antonella, Bellin, Milena, Sartori, Geppo, Carbonera, Donatella, Salviati, Leonardo, Costantini, Paola

“…Friedreich ataxia (FRDA) is a rare, inherited neurodegenerative disease caused by an expanded GAA repeat in the first intron of the FXN gene, leading to…”
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Searching for Frataxin Function: Exploring the Analogy with Nqo15, the Frataxin-like Protein of Respiratory Complex I from Thermus thermophilus by Doni, Davide, Cavallari, Eva, Noguera, Martin Ezequiel, Gentili, Hernan Gustavo, Cavion, Federica, Parisi, Gustavo, Fornasari, Maria Silvina, Sartori, Geppo, Santos, Javier, Bellanda, Massimo, Carbonera, Donatella, Costantini, Paola, Bortolus, Marco

“…Nqo15 is a subunit of respiratory complex I of the bacterium , with strong structural similarity to human frataxin (FXN), a protein involved in the…”
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Correction: Human frataxin, the Friedreich ataxia deficient protein, interacts with mitochondrial respiratory chain by Doni, Davide, Cavion, Federica, Bortolus, Marco, Baschiera, Elisa, Muccioli, Silvia, Tombesi, Giulia, d’Ettorre, Federica, Ottaviani, Daniele, Marchesan, Elena, Leanza, Luigi, Greggio, Elisa, Ziviani, Elena, Russo, Antonella, Bellin, Milena, Sartori, Geppo, Carbonera, Donatella, Salviati, Leonardo, Costantini, Paola

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Effects of Fe2+/Fe3+ Binding to Human Frataxin and Its D122Y Variant, as Revealed by Site-Directed Spin Labeling (SDSL) EPR Complemented by Fluorescence and Circular Dichroism Spectroscopies by Doni, Davide, Passerini, Leonardo, Audran, Gérard, Marque, Sylvain R. A., Schulz, Marvin, Santos, Javier, Costantini, Paola, Bortolus, Marco, Carbonera, Donatella

“…Frataxin is a highly conserved protein whose deficiency results in the neurodegenerative disease Friederich’s ataxia. Frataxin’s actual physiological function…”
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The cyanobacterium Synechocystis sp. PCC 6803 is able to express an active [FeFe]-hydrogenase without additional maturation proteins by Berto, Paola, D’Adamo, Sarah, Bergantino, Elisabetta, Vallese, Francesca, Giacometti, Giorgio Mario, Costantini, Paola

“…► A [FeFe]-hydrogenase has been expressed in a cyanobacterium without its maturases. ► The heterologous enzyme evolves hydrogen gas in vitro. ► The host…”
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Identifying conformational changes with site-directed spin labeling reveals that the GTPase domain of HydF is a molecular switch by Galazzo, Laura, Maso, Lorenzo, De Rosa, Edith, Bortolus, Marco, Doni, Davide, Acquasaliente, Laura, De Filippis, Vincenzo, Costantini, Paola, Carbonera, Donatella

“…[FeFe]-hydrogenases catalyse the reduction of protons to hydrogen at a complex 2Fe[4Fe4S] center called H-cluster. The assembly of this active site is a…”
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DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster by De Lazzari, Federica, Agostini, Francesco, Doni, Davide, Malacrida, Sandro, Zordan, Mauro A., Costantini, Paola, Bubacco, Luigi, Sandrelli, Federica, Bisaglia, Marco

“…Redox homeostasis is a vital process the maintenance of which is assured by the presence of numerous antioxidant small molecules and enzymes and the alteration…”
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A Combined Spectroscopic and In Silico Approach to Evaluate the Interaction of Human Frataxin with Mitochondrial Superoxide Dismutase by Doni, Davide, Meggiolaro, Marta, Santos, Javier, Audran, Gérard, Marque, Sylvain R A, Costantini, Paola, Bortolus, Marco, Carbonera, Donatella

“…Frataxin (FXN) is a highly conserved mitochondrial protein whose deficiency causes Friedreich's ataxia, a neurodegenerative disease. The precise physiological…”
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Two distinct pathways leading to nuclear apoptosis by Susin, S A, Daugas, E, Ravagnan, L, Samejima, K, Zamzami, N, Loeffler, M, Costantini, P, Ferri, K F, Irinopoulou, T, Prévost, M C, Brothers, G, Mak, T W, Penninger, J, Earnshaw, W C, Kroemer, G

“…Apaf-1(-/-) or caspase-3(-/-) cells treated with a variety of apoptosis inducers manifest apoptosis-associated alterations including the translocation of…”
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Molecular characterization of mitochondrial apoptosis-inducing factor by Kroemer, Guido, Susin, Santos A, Lorenzo, Hans K, Zamzami, Naoufal, Marzo, Isabel, Snow, Bryan E, Brothers, Greg M, Mangion, Joan, Jacotot, Etienne, Costantini, Paola, Loeffler, Markus, Larochette, Nathanael, Goodlett, David R, Aebersold, Ruedi, Siderovski, David P, Penninger, Josef M

“…Mitochondria play a key part in the regulation of apoptosis (cell death). Their intermembrane space contains several proteins that are liberated through the…”
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[NiFe]-hydrogenase is essential for cyanobacterium Synechocystis sp. PCC 6803 aerobic growth in the dark by De Rosa, Edith, Checchetto, Vanessa, Franchin, Cinzia, Bergantino, Elisabetta, Berto, Paola, Szabò, Ildikò, Giacometti, Giorgio M., Arrigoni, Giorgio, Costantini, Paola

“…The cyanobacterium Synechocystis sp. PCC 6803 has a bidirectional [NiFe]-hydrogenase (Hox hydrogenase) which reversibly reduces protons to H 2 . This enzyme is…”
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NADH Oxidase Activity of Mitochondrial Apoptosis-inducing Factor by Miramar, M. Dolores, Costantini, Paola, Ravagnan, Luigi, Saraiva, Ligia M., Haouzi, Delphine, Brothers, Greg, Penninger, Josef M., Peleato, M. Luisa, Kroemer, Guido, Susin, Santos A.

“…Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein, which translocates to the nucleus during apoptosis and causes chromatin condensation and large…”
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Diagnosis and management of infertility: NICE-adapted guidelines from the Italian Society of Human Reproduction by Palomba, Stefano, Viganò, Paola, Chamayou, Sandrine, Donarelli, Zaira, Costantini, Maria Paola, Marci, Roberto, Piomboni, Paola, Fino, Egidio, Montano, Luigi, Guglielmino, Antonino, Somigliana, Edgardo

“…In Italy the fertility rate is very low, and an increasing number of patients are infertile and require treatments. The Italian Law concerning the safety of…”
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The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore by Jacotot, E, Ravagnan, L, Loeffler, M, Ferri, K F, Vieira, H L, Zamzami, N, Costantini, P, Druillennec, S, Hoebeke, J, Briand, J P, Irinopoulou, T, Daugas, E, Susin, S A, Cointe, D, Xie, Z H, Reed, J C, Roques, B P, Kroemer, G

“…Viral protein R (Vpr) encoded by HIV-1 is a facultative inducer of apoptosis. When added to intact cells or purified mitochondria, micromolar and submicromolar…”
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Modulation of the Mitochondrial Permeability Transition Pore by Pyridine Nucleotides and Dithiol Oxidation at Two Separate Sites by Costantini, P, Chernyak, B V, Petronilli, V, Bernardi, P

“…After accumulation of a Ca load, the addition of uncoupler to respiring rat liver mitochondria is followed by opening of the permeability transition pore…”
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Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis by COSTANTINI, P, BELZACQ, A.-S, LA VIEIRA, H, LAROCHETTE, N, DE PABLO, M. A, ZAMZAMI, N, SUSIN, S. A, BRENNER, C, KROEMER, G

“…Mitochondrial membrane permeabilization is a critical event in the process leading to physiological or chemotherapy-induced apoptosis. This permeabilization…”
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Bid acts on the permeability transition pore complex to induce apoptosis by ZAMZAMI, Naoufal, EL HAMEL, Chahrazed, KROEMER, Guido, MAISSE, Carine, BRENNER, Catherine, MUNOZ-PINEDO, Cristina, BELZACQ, Anne-Sophie, COSTANTINI, Paola, VIEIRA, Helena, LOEFFLER, Markus, MOLLE, Gérard

“…Similar to most if not all pro-apoptotic members of the Bcl-2 family, Bid (and its truncated product t-Bid) triggers cell death via mitochondrial membrane…”
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GD3 ganglioside directly targets mitochondria in a bcl‐2‐controlled fashion by Rippo, Maria Rita, Malisan, Florence, Rayagnan, Luigi, Tomassini, Barbara, Condo, Ivano, Costantini, Paola, Susin, Santos A., Rufini, Alessandra, Todaro, Matilde, Kroemer, Guido, Testi, Roberto

“…ABSTRACT Lipid and glycolipid diffusible mediators are involved in the intracellular progression and amplification of apoptotic signals. GD3 ganglioside is…”
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Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore by RAVAGNAN, L, MARZO, I, ZHIHUA XIE, REED, J. C, KROEMER, G, COSTANTINI, P, SUSIN, S. A, ZAMZAMI, N, PETIT, P. X, HIRSCH, F, GOULBERN, M, POUPON, M.-F, MICCOLI, L

“…The molecular mode of action of lonidamine, a therapeutic agent employed in cancer chemotherapy, has been elusive. Here we provide evidence that lonidamine…”
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