Search Results - "Costa, Valerio"

LncRNAs in Cancer: From garbage to Junk by Aprile, Marianna, Katopodi, Vicky, Leucci, Eleonora, Costa, Valerio

“…Sequencing-based transcriptomics has significantly redefined the concept of genome complexity, leading to the identification of thousands of lncRNA genes…”
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GIPR expression is induced by thiazolidinediones in a PPARγ-independent manner and repressed by obesogenic stimuli by Cataldi, Simona, Aprile, Marianna, Perfetto, Caterina, Angot, Brice, Cormont, Mireille, Ciccodicola, Alfredo, Tanti, Jean-Francois, Costa, Valerio

“…Adipose tissue (AT) dysfunctions are associated with the onset of insulin resistance (IR) and type 2 diabetes mellitus (T2DM). Targeting glucose-dependent…”
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Pan-Cancer Mutational and Transcriptional Analysis of the Integrator Complex by Federico, Antonio, Rienzo, Monica, Abbondanza, Ciro, Costa, Valerio, Ciccodicola, Alfredo, Casamassimi, Amelia

“…The integrator complex has been recently identified as a key regulator of RNA Polymerase II-mediated transcription, with many functions including the…”
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Glucose impacts onto the reciprocal reprogramming between mammary adipocytes and cancer cells by Ambrosio, Maria Rosaria, Adriaens, Michiel, Derks, Kasper, Migliaccio, Teresa, Costa, Valerio, Liguoro, Domenico, Cataldi, Simona, D’Esposito, Vittoria, Maneli, Giovanni, Bassolino, Rita, Di Paola, Simone, Pirozzi, Marinella, Schonauer, Fabrizio, D’Andrea, Francesco, Beguinot, Francesco, Arts, Ilja, Formisano, Pietro

“…An established hallmark of cancer cells is metabolic reprogramming, largely consisting in the exacerbated glucose uptake. Adipocytes in the tumor…”
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Diabetic Retinopathy: Are lncRNAs New Molecular Players and Targets? by Cataldi, Simona, Tramontano, Mariagiovanna, Costa, Valerio, Aprile, Marianna, Ciccodicola, Alfredo

“…The growing incidence of diabetes mellitus worldwide implies the increasing prevalence of several related macro- (e.g., hypertension and atherosclerosis) and…”
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PPARγΔ5, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPARγ Function and Adipocyte Differentiation by Aprile, Marianna, Cataldi, Simona, Ambrosio, Maria Rosaria, D’Esposito, Vittoria, Lim, Koini, Dietrich, Arne, Blüher, Matthias, Savage, David Bousfield, Formisano, Pietro, Ciccodicola, Alfredo, Costa, Valerio

“…Peroxisome-proliferator-activated receptor γ (PPARγ) regulates glucose and lipid homeostasis, insulin signaling, and adipocyte differentiation. Here, we report…”
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Unique true predicted neoantigens (TPNAs) correlates with anti-tumor immune control in HCC patients by Petrizzo, Annacarmen, Tagliamonte, Maria, Mauriello, Angela, Costa, Valerio, Aprile, Marianna, Esposito, Roberta, Caporale, Andrea, Luciano, Antonio, Arra, Claudio, Tornesello, Maria Lina, Buonaguro, Franco M, Buonaguro, Luigi

“…A novel prediction algorithm is needed for the identification of effective tumor associated mutated neoantigens. Only those with no homology to self wild type…”
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The Chromatin-Oxygen Sensor Gene KDM5C Associates with Novel Hypoxia-Related Signatures in Glioblastoma Multiforme by Drongitis, Denise, Verrillo, Lucia, De Marinis, Pasqualino, Orabona, Pasquale, Caiola, Agnese, Turitto, Giacinto, Alfieri, Alessandra, Bruscella, Sara, Gentile, Marisa, Moriello, Vania, Sannino, Ettore, Di Muccio, Ines, Costa, Valerio, Miano, Maria Giuseppina, de Bellis, Alberto

“…Glioblastoma multiforme (GBM) is a fatal brain tumor without effective drug treatment. In this study, we highlight, for the first time, the contribution of…”
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Hepatic Insulin Resistance in Hyperthyroid Rat Liver: Vitamin E Supplementation Highlights a Possible Role of ROS by Fasciolo, Gianluca, Napolitano, Gaetana, Aprile, Marianna, Cataldi, Simona, Costa, Valerio, Ciccodicola, Alfredo, Di Meo, Sergio, Venditti, Paola

“…Thyroid hormones are normally involved in glycaemic control, but their excess can lead to altered glucose metabolism and insulin resistance (IR). Since…”
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Novel transcription factor variants through RNA-sequencing: the importance of being "alternative" by Scarpato, Margherita, Federico, Antonio, Ciccodicola, Alfredo, Costa, Valerio

“…Alternative splicing is a pervasive mechanism of RNA maturation in higher eukaryotes, which increases proteomic diversity and biological complexity. It has a…”
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miR-34b/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation by De Gregorio, Roberto, Pulcrano, Salvatore, De Sanctis, Claudia, Volpicelli, Floriana, Guatteo, Ezia, von Oerthel, Lars, Latagliata, Emanuele Claudio, Esposito, Roberta, Piscitelli, Rosa Maria, Perrone-Capano, Carla, Costa, Valerio, Greco, Dario, Puglisi-Allegra, Stefano, Smidt, Marten P., di Porzio, Umberto, Caiazzo, Massimiliano, Mercuri, Nicola Biagio, Li, Meng, Bellenchi, Gian Carlo

“…The differentiation of dopaminergic neurons requires concerted action of morphogens and transcription factors acting in a precise and well-defined time window…”
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Muscle Oxidative Stress Plays a Role in Hyperthyroidism-Linked Insulin Resistance by Fasciolo, Gianluca, Napolitano, Gaetana, Aprile, Marianna, Cataldi, Simona, Costa, Valerio, Muscari Tomajoli, Maria Teresa, Lombardi, Assunta, Di Meo, Sergio, Venditti, Paola

“…While a low level of ROS plays a role in cellular regulatory processes, a high level can lead to oxidative stress and cellular dysfunction. Insulin resistance…”
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Antigen delivery by filamentous bacteriophage fd displaying an anti‐DEC‐205 single‐chain variable fragment confers adjuvanticity by triggering a TLR9‐mediated immune response by Sartorius, Rossella, D'Apice, Luciana, Trovato, Maria, Cuccaro, Fausta, Costa, Valerio, De Leo, Maria Giovanna, Marzullo, Vincenzo Manuel, Biondo, Carmelo, D'Auria, Sabato, De Matteis, Maria Antonietta, Ciccodicola, Alfredo, De Berardinis, Piergiuseppe

“…Filamentous bacteriophage fd particles delivering antigenic determinants via DEC‐205 (fdsc‐αDEC) represent a powerful delivery system that induces CD8 + T‐cell…”
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Pharmacogenomics of Drug Response in Type 2 Diabetes: Toward the Definition of Tailored Therapies? by Ciccodicola, Alfredo, Costa, Valerio, Ziviello, Carmela, Pollastro, Carla

“…Type 2 diabetes is one of the major causes of mortality with rapidly increasing prevalence. Pharmacological treatment is the first recommended approach after…”
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TNFα Mediates Inflammation-Induced Effects on PPARG Splicing in Adipose Tissue and Mesenchymal Precursor Cells by Cataldi, Simona, Aprile, Marianna, Melillo, Daniela, Mucel, Inès, Giorgetti-Peraldi, Sophie, Cormont, Mireille, Italiani, Paola, Blüher, Matthias, Tanti, Jean-François, Ciccodicola, Alfredo, Costa, Valerio

“…Low-grade chronic inflammation and reduced differentiation capacity are hallmarks of hypertrophic adipose tissue (AT) and key contributors of insulin…”
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Computational Analysis of Single Nucleotide Polymorphisms Associated with Altered Drug Responsiveness in Type 2 Diabetes by Costa, Valerio, Federico, Antonio, Pollastro, Carla, Ziviello, Carmela, Cataldi, Simona, Formisano, Pietro, Ciccodicola, Alfredo

“…Type 2 diabetes (T2D) is one of the most frequent mortality causes in western countries, with rapidly increasing prevalence. Anti-diabetic drugs are the first…”
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Alternative Splicing in Adhesion- and Motility-Related Genes in Breast Cancer by Aversa, Rosanna, Sorrentino, Anna, Esposito, Roberta, Ambrosio, Maria Rosaria, Amato, Angela, Zambelli, Alberto, Ciccodicola, Alfredo, D'Apice, Luciana, Costa, Valerio

“…Breast cancer is the most common tumor and the second leading cause of cancer death among woman, mainly caused by the metastatic spread. Tumor invasiveness is…”
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Massive-scale RNA-Seq analysis of non ribosomal transcriptome in human trisomy 21 by Costa, Valerio, Angelini, Claudia, D'Apice, Luciana, Mutarelli, Margherita, Casamassimi, Amelia, Sommese, Linda, Gallo, Maria Assunta, Aprile, Marianna, Esposito, Roberta, Leone, Luigi, Donizetti, Aldo, Crispi, Stefania, Rienzo, Monica, Sarubbi, Berardo, Calabrò, Raffaele, Picardi, Marco, Salvatore, Paola, Infante, Teresa, De Berardinis, Piergiuseppe, Napoli, Claudio, Ciccodicola, Alfredo

“…Hybridization- and tag-based technologies have been successfully used in Down syndrome to identify genes involved in various aspects of the pathogenesis…”
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Harmonization of Next-Generation Sequencing Procedure in Italian Laboratories: A Multi-Institutional Evaluation of the SiRe® Panel by Malapelle, Umberto, Pepe, Francesco, Pisapia, Pasquale, Sgariglia, Roberta, Nacchio, Mariantonia, De Luca, Caterina, Lacalamita, Rosanna, Tommasi, Stefania, Pinto, Rosamaria, Palomba, Grazia, Palmieri, Giuseppe, Vacirca, Davide, Barberis, Massimo, Bottillo, Irene, Grammatico, Paola, Grillo, Lucia Rosalba, Costa, Valerio, Smeraglio, Riccardo, Bruzzese, Dario, Troncone, Giancarlo

“…Next-generation sequencing (NGS) needs to be validated and standardized to ensure that cancer patients are reliably selected for target treatments. In Italy,…”
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In-Vitro-Generated Hypertrophic-Like Adipocytes Displaying PPARG Isoforms Unbalance Recapitulate Adipocyte Dysfunctions In Vivo by Aprile, Marianna, Cataldi, Simona, Perfetto, Caterina, Ambrosio, Maria Rosaria, Italiani, Paola, Tatè, Rosarita, Blüher, Matthias, Ciccodicola, Alfredo, Costa, Valerio

“…Reduced neo-adipogenesis and dysfunctional lipid-overloaded adipocytes are hallmarks of hypertrophic obesity linked to insulin resistance. Identifying…”
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