Search Results - "Costa, Vívian V."

Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope by Robinson, Luke N., Tharakaraman, Kannan, Rowley, Kirk J., Costa, Vivian V., Chan, Kuan Rong, Wong, Yee Hwa, Ong, Li Ching, Tan, Hwee Cheng, Koch, Tyree, Cain, David, Kirloskar, Rama, Viswanathan, Karthik, Liew, Chong Wai, Tissire, Hamid, Ramakrishnan, Boopathy, Myette, James R., Babcock, Gregory J., Sasisekharan, V., Alonso, Sylvie, Chen, Jianzhu, Lescar, Julien, Shriver, Zachary, Ooi, Eng Eong, Sasisekharan, Ram

“…Dengue is the most common vector-borne viral disease, causing nearly 400 million infections yearly. Currently there are no approved therapies. Antibody…”
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Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide by Jackman, Joshua A., Costa, Vivian V., Park, Soohyun, Real, Ana Luiza C. V., Park, Jae Hyeon, Cardozo, Pablo L., Ferhan, Abdul Rahim, Olmo, Isabella G., Moreira, Thaiane P., Bambirra, Jordana L., Queiroz, Victoria F., Queiroz-Junior, Celso M., Foureaux, Giselle, Souza, Danielle G., Ribeiro, Fabiola M., Yoon, Bo Kyeong, Wynendaele, Evelien, De Spiegeleer, Bart, Teixeira, Mauro M., Cho, Nam-Joon

“…Zika virus is a mosquito-borne virus that is associated with neurodegenerative diseases, including Guillain–Barré syndrome 1 and congenital Zika syndrome 2 …”
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NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B4 in a murine model of gout by Amaral, Flávio A., Costa, Vivian V., Tavares, Livia D., Sachs, Daniela, Coelho, Fernanda M., Fagundes, Caio T., Soriani, Frederico M., Silveira, Tatiana N., Cunha, Larissa D., Zamboni, Dario S., Quesniaux, Valerie, Peres, Raphael S., Cunha, Thiago M., Cunha, Fernando Q., Ryffel, Bernhard, Souza, Daniele G., Teixeira, Mauro M.

“…Objective Deposition of monosodium urate monohydrate (MSU) crystals in the joints promotes an intense inflammatory response and joint dysfunction. This study…”
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Acute coronavirus infection triggers a TNF-dependent osteoporotic phenotype in mice by Queiroz-Junior, Celso M., Santos, Anna C.P.M., Gonçalves, Matheus R., Brito, Camila B., Barrioni, Breno, Almeida, Pedro J., Gonçalves-Pereira, Marcela H., Silva, Tarcília, Oliveira, Sicília R., Pereira, Marivalda M., Santiago, Helton C., Teixeira, Mauro M., Costa, Vivian V.

“…Millions of people died during the COVID-19 pandemic, but the vast majority of infected individuals survived. Now, some consequences of the disease, known as…”
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Zika Virus Promotes Neuronal Cell Death in a Non-Cell Autonomous Manner by Triggering the Release of Neurotoxic Factors by Olmo, Isabella G, Carvalho, Toniana G, Costa, Vivian V, Alves-Silva, Juliana, Ferrari, Carolina Z, Izidoro-Toledo, Tatiane C, da Silva, Juliana F, Teixeira, Antonio L, Souza, Danielle G, Marques, Joao T, Teixeira, Mauro M, Vieira, Luciene B, Ribeiro, Fabiola M

“…Zika virus (ZIKV) has recently caused a worldwide outbreak of infections associated with severe neurological complications, including microcephaly in infants…”
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Cooperative role of tumour necrosis factor‐α, interleukin‐1β and neutrophils in a novel behavioural model that concomitantly demonstrates articular inflammation and hypernociception in mice by Sachs, Daniela, Coelho, Fernanda M, Costa, Vívian V, Lopes, Fernando, Pinho, Vanessa, Amaral, Flávio A, Silva, Tarcília A, Teixeira, Antônio L, Souza, Daniele G, Teixeira, Mauro M

“…BACKGROUND AND PURPOSE Chronic joint inflammation and pain are the hallmarks of disease in patients with inflammatory arthritis, notably rheumatoid arthritis…”
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Profound downregulation of neural transcription factor Npas4 and Nr4a family in fetal mice neurons infected with Zika virus by Alpuche-Lazcano, Sergio P, Saliba, James, Costa, Vivian V, Campolina-Silva, Gabriel H, Marim, Fernanda M, Ribeiro, Lucas S, Blank, Volker, Mouland, Andrew J, Teixeira, Mauro M, Gatignol, Anne

“…Zika virus (ZIKV) infection of neurons leads to neurological complications and congenital malformations of the brain of neonates. To date, ZIKV mechanism of…”
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Mechanisms of the anti-inflammatory actions of the angiotensin type 1 receptor antagonist losartan in experimental models of arthritis by Silveira, Kátia D., Coelho, Fernanda M., Vieira, Angélica T., Barroso, Lívia C., Queiroz-Junior, Celso M., Costa, Vívian V., Sousa, Larissa F.C., Oliveira, Marilene L., Bader, Michael, Silva, Tarcíla A., Santos, Robson A.S., Silva, Ana Cristina Simões e, Teixeira, Mauro M.

“…•The study evaluated the role of losartan in experimental arthritis.•Losartan reduced neutrophil infiltration and local cytokine levels.•Losartan also improved…”
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The chemokine receptors CXCR1/CXCR2 modulate antigen‐induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature by Coelho, Fernanda M., Pinho, Vanessa, Amaral, Flávio A., Sachs, Daniela, Costa, Vívian V., Rodrigues, David H., Vieira, Angélica T., Silva, Tarcília A., Souza, Daniele G., Bertini, Riccardo, Teixeira, Antônio L., Teixeira, Mauro M.

“…Objective The chemokine receptors CXCR1 and CXCR2 play a role in mediating neutrophil recruitment and neutrophil‐dependent injury in several models of…”
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IFN-γ production depends on IL-12 and IL-18 combined action and mediates host resistance to dengue virus infection in a nitric oxide-dependent manner by Fagundes, Caio T, Costa, Vivian V, Cisalpino, Daniel, Amaral, Flávio A, Souza, Patrícia R S, Souza, Rafael S, Ryffel, Bernhard, Vieira, Leda Q, Silva, Tarcília A, Atrasheuskaya, Alena, Ignatyev, George, Sousa, Lirlândia P, Souza, Danielle G, Teixeira, Mauro M

“…Dengue is a mosquito-borne disease caused by one of four serotypes of Dengue virus (DENV-1-4). Severe dengue infection in humans is characterized by…”
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Host Immune Response to ZIKV in an Immunocompetent Embryonic Mouse Model of Intravaginal Infection by Khaiboullina, Svetlana F, Lopes, Priscila, de Carvalho, Toniana G, Real, Ana Luiza C V, Souza, Danielle G, Costa, Vivian V, Teixeira, Mauro M, Bloise, Enrrico, Verma, Subhash C, Ribeiro, Fabiola M

“…Zika virus (ZIKV) only induces mild symptoms in adults; however, it can cause congenital Zika syndrome (CZS), including microcephaly. Most of the knowledge on…”
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Identification of Piecemeal Degranulation and Vesicular Transport of MBP-1 in Liver-Infiltrating Mouse Eosinophils During Acute Experimental Schistosoma mansoni Infection by Dias, Felipe F, Amaral, Kátia B, Malta, Kássia K, Silva, Thiago P, Rodrigues, Gabriel S C, Rosa, Florence M, Rodrigues, Gisele O L, Costa, Vivian V, Chiarini-Garcia, Hélio, Weller, Peter F, Melo, Rossana C N

“…Eosinophils have been long associated with helminthic infections, although their functions in these diseases remain unclear. During schistosomiasis caused by…”
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Resolution of neutrophilic inflammation by H2O2 in antigen‐induced arthritis by Lopes, Fernando, Coelho, Fernanda M., Costa, Vivian V., Vieira, Érica L. M., Sousa, Lirlândia P., Silva, Tarcília A., Vieira, Leda Q., Teixeira, Mauro M., Pinho, Vanessa

“…Objective Neutrophil accumulation contributes to the pathogenesis of rheumatoid arthritis. This study was undertaken to examine the ability of H2O2 to…”
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E3 Ubiquitin Ligase Smurf1 Regulates the Inflammatory Response in Macrophages and Attenuates Hepatic Damage during Betacoronavirus Infection by Souza-Costa, Luiz P, Santos, Felipe R S, Pimenta, Jordane C, Queiroz-Junior, Celso M, Tana, Fernanda L, Teixeira, Danielle C, Couto, Manoela G G, Oliveira, Natalia F M, Pereira, Rafaela D, Beltrami, Vinicius A, Costa, Pedro A C, Lacerda, Larisse S B, Andrade-Chaves, Josiane T, Guimarães, Pedro P G, Aguiar, Renato S, Teixeira, Mauro M, Costa, Vivian V, Franco, Luis H

“…The E3 ubiquitin ligase Smurf1 catalyzes the ubiquitination and proteasomal degradation of several protein substrates related to inflammatory responses and…”
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Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo by de Freitas, Caroline S, Higa, Luiza M, Sacramento, Carolina Q, Ferreira, André C, Reis, Patrícia A, Delvecchio, Rodrigo, Monteiro, Fabio L, Barbosa-Lima, Giselle, James Westgarth, Harrison, Vieira, Yasmine Rangel, Mattos, Mayara, Rocha, Natasha, Hoelz, Lucas Villas Bôas, Leme, Rennan Papaleo Paes, Bastos, Mônica M, Rodrigues, Gisele Olinto L, Lopes, Carla Elizabeth M, Queiroz-Junior, Celso Martins, Lima, Cristiano X, Costa, Vivian V, Teixeira, Mauro M, Bozza, Fernando A, Bozza, Patrícia T, Boechat, Nubia, Tanuri, Amilcar, Souza, Thiago Moreno L

“…Yellow fever virus (YFV) is a member of the Flaviviridae family. In Brazil, yellow fever (YF) cases have increased dramatically in sylvatic areas neighboring…”
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Annexin A1-FPR2/ALX Signaling Axis Regulates Acute Inflammation during Chikungunya Virus Infection by de Araújo, Simone, de Melo Costa, Victor R, Santos, Franciele M, de Sousa, Carla D. Ferreira, Moreira, Thaiane P, Gonçalves, Matheus R, Félix, Franciel B, Queiroz-Junior, Celso M, Campolina-Silva, Gabriel H, Nogueira, Maurício Lacerda, Sugimoto, Michelle A, Bonilha, Caio S, Perretti, Mauro, Souza, Danielle G, Costa, Vivian V, Teixeira, Mauro M

“…Chikungunya (CHIKV) is an arthritogenic alphavirus that causes a self-limiting disease usually accompanied by joint pain and/or polyarthralgia with disabling…”
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A model of DENV-3 infection that recapitulates severe disease and highlights the importance of IFN-γ in host resistance to infection by Costa, Vivian V, Fagundes, Caio T, Valadão, Deborah F, Cisalpino, Daniel, Dias, Ana Carolina F, Silveira, Kátia D, Kangussu, Lucas M, Ávila, Thiago V, Bonfim, Maria Rosa Q, Bonaventura, Daniela, Silva, Tarcília A, Sousa, Lirlândia P, Rachid, Milene A, Vieira, Leda Q, Menezes, Gustavo B, de Paula, Ana Maria, Atrasheuskaya, Alena, Ignatyev, George, Teixeira, Mauro M, Souza, Danielle G

“…There are few animal models of dengue infection, especially in immunocompetent mice. Here, we describe alterations found in adult immunocompetent mice…”
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Intracerebral infection with dengue-3 virus induces meningoencephalitis and behavioral changes that precede lethality in mice by Amaral, Debora C G, Rachid, Milene A, Vilela, Marcia C, Campos, Roberta D L, Ferreira, Gustavo P, Rodrigues, David H, Lacerda-Queiroz, Norinne, Miranda, Aline S, Costa, Vivian V, Campos, Marco A, Kroon, Erna G, Teixeira, Mauro M, Teixeira, Antonio L

“…Dengue, one of the most important arboviral diseases of humans, may cause severe systemic disease. Although dengue virus (DENV) has been considered to be a…”
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Lithothamnion muelleri treatment ameliorates inflammatory and hypernociceptive responses in antigen-induced arthritis in mice by Costa, Vivian V, Amaral, Flavio A, Coelho, Fernanda M, Queiroz-Junior, Celso M, Malagoli, Bruna G, Gomes, Jose Hugo S, Lopes, Fernando, Silveira, Kátia D, Sachs, Daniela, Fagundes, Caio T, Tavares, Lívia D, Pinho, Vanessa, Silva, Tarcilia A, Teixeira, Mauro M, Braga, Fernão C, Souza, Danielle G

“…Rheumatoid Arthritis (RA) is a chronic disease characterized by persistent inflammation and pain. Alternative therapies to reduce these symptoms are needed…”
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Proteasome Inhibition Suppresses Dengue Virus Egress in Antibody Dependent Infection by Choy, Milly M, Zhang, Summer L, Costa, Vivian V, Tan, Hwee Cheng, Horrevorts, Sophie, Ooi, Eng Eong

“…The mosquito-borne dengue virus (DENV) is a cause of significant global health burden, with an estimated 390 million infections occurring annually. However, no…”
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