Search Results - "Costa, Narciso"

The functionality of a therapeutic antibody candidate restored by a single mutation from proline to threonine in the variable region by Hautiere, Marie, Maffucci, Irene, Costa, Narciso, Herbet, Amaury, Essono, Sosthene, Padiolleau-Lefevre, Séverine, Boquet, Didier

“…mAbs play an essential role in the therapeutic arsenal. Our laboratory has patented the Rendomab-B49 mAb targeting the endothelin B receptor (ET ). This G…”
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Deciphering neuronal deficit and protein profile changes in human brain organoids from patients with creatine transporter deficiency by Broca-Brisson, Léa, Harati, Rania, Disdier, Clémence, Mozner, Orsolya, Gaston-Breton, Romane, Maïza, Auriane, Costa, Narciso, Guyot, Anne-Cécile, Sarkadi, Balazs, Apati, Agota, Skelton, Matthew R, Madrange, Lucie, Yates, Frank, Armengaud, Jean, Hamoudi, Rifat, Mabondzo, Aloïse

“…Creatine transporter deficiency (CTD) is an X-linked disease caused by mutations in the SLC6A8 gene. The impaired creatine uptake in the brain results in…”
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Investigating the utility of minimized sample preparation and high-resolution mass spectrometry for quantification of monoclonal antibody drugs by Nguyen, Tam T.T.N., Mistarz, Ulrik H., Costa, Narciso, Herbet, Amaury, Boquet, Didier, Becher, François, Rand, Kasper D.

“…•Three different LC–MS/MS methods using QqQ, Q-TOF and Q-Orbitrap were developed and compared for quantitation of a model mAb in biological fluids.•The…”
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Dodecyl creatine ester improves cognitive function and identifies key protein drivers including KIF1A and PLCB1 in a mouse model of creatine transporter deficiency by Mabondzo, Aloïse, Harati, Rania, Broca-Brisson, Léa, Guyot, Anne-Cécile, Costa, Narciso, Cacciante, Francesco, Putignano, Elena, Baroncelli, Laura, Skelton, Matthew R, Saab, Cathy, Martini, Emmanuelle, Benech, Henri, Joudinaud, Thomas, Gaillard, Jean-Charles, Armengaud, Jean, Hamoudi, Rifat

“…Creatine transporter deficiency (CTD), a leading cause of intellectual disability is a result of the mutation in the gene encoding the creatine transporter…”
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Análise da variação de eficiência dos Institutos de Educação, Ciência e Tecnologia by Miranda, Jéssica Letícia de Souza, Da Costa, Narciso Rodrigues, Corrêa, Danielle Cristina Gonzaga, Felix, Francisco do Nascimento, De Mattos, Carlos André Corrêa, Corrêa, Alessandro de Castro

“…Este estudo analisou a variação da eficiência dos Institutos da Rede Federal de Educação, Ciência e Tecnologia no período de 2014 a 2016. Adotou-se o Modelo…”
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ImmunoPET imaging–based pharmacokinetic profiles of an antibody and its Fab targeting endothelin A receptors on glioblastoma stem cells in a preclinical orthotopic model by Hautiere, Marie, Vivier, Delphine, Pineau, Donovan, Denis, Caroline, Kereselidze, Dimitri, Herbet, Amaury, Costa, Narciso, Goncalves, Victor, Selingue, Erwan, Larrat, Benoit, Hugnot, Jean Philippe, Denat, Franck, Boquet, Didier, Truillet, Charles

“…Background The resistance of glioblastoma stem cells (GSCs) to treatment is one of the causes of glioblastoma (GBM) recurrence. Endothelin A receptor (ET A )…”
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Proof-of-Concept Study of Drug Brain Permeability Between in Vivo Human Brain and an in Vitro iPSCs-Human Blood-Brain Barrier Model by Roux, Gwenaëlle Le, Jarray, Rafika, Guyot, Anne-Cécile, Pavoni, Serena, Costa, Narciso, Théodoro, Frédéric, Nassor, Ferid, Pruvost, Alain, Tournier, Nicolas, Kiyan, Yulia, Langer, Oliver, Yates, Frank, Deslys, Jean Philippe, Mabondzo, Aloïse

“…The development of effective central nervous system (CNS) drugs has been hampered by the lack of robust strategies to mimic the blood-brain barrier (BBB) and…”
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Preoperative PET imaging and fluorescence-guided surgery of human glioblastoma using dual-labeled antibody targeting ETA receptors in a preclinical mouse model: A theranostic approach by Hautiere, Marie, Vivier, Delphine, Dorval, Paul, Pineau, Donovan, Kereselidze, Dimitri, Denis, Caroline, Herbet, Amaury, Costa, Narciso, Bernhard, Claire, Goncalves, Victor, Selingue, Erwan, Larrat, Benoit, Dancer, Pierre Alix, Hugnot, Jean-Philippe, Boquet, Didier, Truillet, Charles, Denat, Franck

“…Rationale: Glioblastoma (GBM) poses significant challenges regarding complete tumor removal due to its heterogeneity and invasiveness, emphasizing the need for…”
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Deciphering neuronal deficit and protein profile changes in human brain organoids from patients with creatine transporter deficiency by Broca-Brisson, Léa, Harati, Rania, Disdier, Clémence, Mozner, Orsolya, Gaston-Breton, Romane, Maïza, Auriane, Costa, Narciso, Guyot, Anne-Cécile, Sarkadi, Balazs, Apati, Agota, Skelton, Matthew R, Madrange, Lucie, Yates, Frank, Armengaud, Jean, Hamoudi, Rifat, Mabondzo, Aloïse

“…Creatine transporter deficiency (CTD) is an X-linked disease caused by mutations in the SLC6A8 gene. The impaired creatine uptake in the brain results in…”
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Preoperative PET imaging and fluorescence-guided surgery of human glioblastoma using dual-labeled antibody targeting ET A receptors in a preclinical mouse model: A theranostic approach by Hautiere, Marie, Vivier, Delphine, Dorval, Paul, Pineau, Donovan, Kereselidze, Dimitri, Denis, Caroline, Herbet, Amaury, Costa, Narciso, Bernhard, Claire, Goncalves, Victor, Selingue, Erwan, Larrat, Benoit, Dancer, Pierre Alix, Hugnot, Jean-Philippe, Boquet, Didier, Truillet, Charles, Denat, Franck

“…Glioblastoma (GBM) poses significant challenges regarding complete tumor removal due to its heterogeneity and invasiveness, emphasizing the need for effective…”
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Deciphering neuronal deficit and protein profile changes in human brain organoids from patients with creatine transporter deficiency by Broca-Brisson, Léa, Harati, Rania, Disdier, Clémence, Mozner, Orsolya, Gaston-Breton, Romane, Maïza, Auriane, Costa, Narciso, Guyot, Anne-Cécile, Sarkadi, Balazs, Apati, Agota, Skelton, Matthew, Madrange, Lucie, Yates, Frank, Armengaud, Jean, Hamoudi, Rifat, Mabondzo, Aloïse

“…Creatine transporter deficiency (CTD) is an X-linked disease caused by mutations in the SLC6A8 gene. The impaired creatine uptake in the brain results in…”
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Rethinking economics: the potential contribution of the classics by Castro Caldas, José, Costa, Ana Narciso, Burns, Tom R.

“…Mainstream views only admit two solutions to social order—separation and coercion. Understanding why association, as a principle of order came to be excluded…”
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A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment by Guyot, Anne-Cécile, Leuxe, Charlotte, Disdier, Clémence, Oumata, Nassima, Costa, Narciso, Roux, Gwenaëlle Le, Varela, Paloma F., Duchon, Arnaud, Charbonnier, Jean Baptiste, Herault, Yann, Pavoni, Serena, Galons, Hervé, Andriambeloson, Emile, Wagner, Stéphanie, Meijer, Laurent, Lund, Amie K., Mabondzo, Aloïse

“…Neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are characterized by increased protein aggregation in the brain, progressive…”
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Investigating the utility of minimized sample preparation and high-resolution mass spectrometry for quantification of monoclonal antibody drugs by Nguyen, Tam T. T. N., Mistarz, Ulrik H., Costa, Narciso, Herbet, Amaury, Boquet, Didier, Becher, Francois, Rand, Kasper D.

“…Determination of the pharmacokinetic (PK) properties of therapeutic monoclonal antibodies (mAbs) is essential for their successful development as drugs. For…”
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Dodecyl creatine ester-loaded nanoemulsion as a promising therapy for creatine transporter deficiency by Ullio-Gamboa, Gabriela, Udobi, Kenea C, Dezard, Sophie, Perna, Marla K, Miles, Keila N, Costa, Narciso, Taran, Frédéric, Pruvost, Alain, Benoit, Jean-Pierre, Skelton, Matthew R, Lonlay, Pascale de, Mabondzo, Aloïse

“…Creatine transporter (CrT) deficiency is an X-linked intellectual disability caused by mutations of CrT. This work focus on the preclinical development of a…”
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Efficiency variation analysis of the Institutes of Education, Science and Technology/Analise da variacao de eficiencia dos Institutos de Educacao, Ciencia e Tecnologia by Miranda, Jessica Leticia de Souza, da Costa, Narciso Rodrigues, Correa, Danielle Cristina Gonzaga, Felix, Francisco do Nascimento, de Mattos, Carlos Andre Correa, Correa, Alessandro de Castro

“…This study analyzes the efficiency variation of the Federal Network of Professional and Technological Education institutes from 2014 to 2016. The data for the…”
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Multitarget selection of catalytic antibodies with [beta]-lactamase activity using phage display by Shahsavarian, Melody A, Chaaya, Nancy, Costa, Narciso, Boquet, Didier, Atkinson, Alexandre, Offmann, Bernard, Kaveri, Srini V, Lacroix-Desmazes, Sébastien, Friboulet, Alain, Avalle, Bérangère, Padiolleau-Lefevre, Séverine

“…[beta]-lactamase enzymes responsible for bacterial resistance to antibiotics are among the most important health threats to the human population today…”
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Refolding of Aggregation-Prone ScFv Antibody Fragments Assisted by Hydrophobically Modified Poly(sodium acrylate) Derivatives by Martin, Nicolas, Costa, Narciso, Wien, Frank, Winnik, Françoise, Ortega, Céline, Herbet, Amaury, Boquet, Didier, Tribet, Christophe C.

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Author Correction: A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment by Guyot, Anne-Cécile, Leuxe, Charlotte, Disdier, Clémence, Oumata, Nassima, Costa, Narciso, Le Roux, Gwenaëlle, Varela, Paloma F., Duchon, Arnaud, Charbonnier, Jean Baptiste, Herault, Yann, Pavoni, Serena, Galons, Hervé, Andriambeloson, Emile, Wagner, Stéphanie, Meijer, Laurent, Lund, Amie K., Mabondzo, Aloïse

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Refolding of Aggregation‐Prone ScFv Antibody Fragments Assisted by Hydrophobically Modified Poly(sodium acrylate) Derivatives by Martin, Nicolas, Costa, Narciso, Wien, Frank, Winnik, Françoise M., Ortega, Céline, Herbet, Amaury, Boquet, Didier, Tribet, Christophe

“…ScFv antibody fragments are a promising alternative to full‐length antibodies for both therapeutic and diagnosis applications. They can be overexpressed in…”
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