Association between INDELs in MicroRNAs and Susceptibility to Gastric Cancer in Amazonian Population

Association between INDELs in MicroRNAs and Susceptibility to Gastric Cancer in Amazonian Population

Gastric cancer (GC) is a multifactorial, complex, and aggressive disease with a prevalence of one million new cases and high global mortality. Factors such as genetic, epigenetic, and environmental changes contribute to the onset and progression of the disease. Identification of INDELs in miRNA and...

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Bibliographic Details
Published in:Genes Vol. 14; no. 1; p. 60
Main Authors: Modesto, Antonio A C, Moraes, Milene R de, Valente, Cristina M D, Costa, Marta S C R, Leal, Diana F da V B, Pereira, Esdras E B, Fernandes, Marianne R, Pinheiro, Jhully A Dos S, Pantoja, Karla B C C, Moreira, Fabiano C, Burbano, Rommel M R, Assumpção, Paulo P de, Santos, Ney P C Dos, Santos, Sidney E B Dos
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 24-12-2022
MDPI
Subjects:
Biomarkers, Tumor - genetics
Biosynthesis
Capillary electrophoresis
Cell growth
Cell migration
Cell proliferation
Chi-square test
Environmental changes
Epigenetics
Gastric cancer
Gene Expression Regulation, Neoplastic
Genes
Genetic diversity
Humans
Localization
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Mutation
Oncogenes
Software
Stomach Neoplasms - pathology
Tumors
United States > US
Amazon Basin
miRNA
susceptibility
gastric cancer
potential biomarker
INDEL
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Summary:Gastric cancer (GC) is a multifactorial, complex, and aggressive disease with a prevalence of one million new cases and high global mortality. Factors such as genetic, epigenetic, and environmental changes contribute to the onset and progression of the disease. Identification of INDELs in miRNA and its target sites in current studies showed an important role in the development of cancer. In GC, miRNAs act as oncogenes or tumor suppressors, favoring important cancer pathways, such as cell proliferation and migration. This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. For this study, 301 patients with GC and 145 individuals from the control group were selected from an admixed population in the Brazilian Amazon. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility. The hsa-miR-4463 was significantly associated with clinical features of GC such as diffuse gastric tumor histological type, "non-cardia" localization region, and early onset. Our findings indicated that INDELs could be potentially functional genetic variants for gastric cancer risk.
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ISSN:2073-4425
2073-4425
DOI:10.3390/genes14010060