Search Results - "Costa, Giosuè"

Inhibition of Human Monoamine Oxidase: Biological and Molecular Modeling Studies on Selected Natural Flavonoids by Carradori, Simone, Gidaro, Maria Concetta, Petzer, Anél, Costa, Giosuè, Guglielmi, Paolo, Chimenti, Paola, Alcaro, Stefano, Petzer, Jacobus P

“…Naturally occurring flavonoids display a plethora of different biological activities, but emerging evidence suggests that this class of compounds may also act…”
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An overview on olfaction in the biological, analytical, computational, and machine learning fields by Chiera, Federica, Costa, Giosuè, Alcaro, Stefano, Artese, Anna

“…Recently, the comprehension of odor perception has advanced, unveiling the mysteries of the molecular receptors within the nasal passages and the intricate…”
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From Homology Modeling to the Hit Identification and Drug Repurposing: A Structure-Based Approach in the Discovery of Novel Potential Anti-Obesity Compounds by Costa, Giosuè, Artese, Anna, Ortuso, Francesco, Alcaro, Stefano

“…Although science and technology have progressed rapidly, de novo drug development has been a costly and time-consuming process over the past decades. In this…”
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ABCC Transporters Mediate the Vacuolar Accumulation of Crocins in Saffron Stigmas by Demurtas, Olivia Costantina, de Brito Francisco, Rita, Diretto, Gianfranco, Ferrante, Paola, Frusciante, Sarah, Pietrella, Marco, Aprea, Giuseppe, Borghi, Lorenzo, Feeney, Mistianne, Frigerio, Lorenzo, Coricello, Adriana, Costa, Giosuè, Alcaro, Stefano, Martinoia, Enrico, Giuliano, Giovanni

“…Compartmentation is a key strategy enacted by plants for the storage of specialized metabolites. The saffron spice owes its red color to crocins, a complex…”
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Current status of antivirals and druggable targets of SARS CoV-2 and other human pathogenic coronaviruses by Artese, Anna, Svicher, Valentina, Costa, Giosuè, Salpini, Romina, Di Maio, Velia Chiara, Alkhatib, Mohammad, Ambrosio, Francesca Alessandra, Santoro, Maria Mercedes, Assaraf, Yehuda G., Alcaro, Stefano, Ceccherini-Silberstein, Francesca

“…Coronaviridae is a peculiar viral family, with a very large RNA genome and characteristic appearance, endowed with remarkable tendency to transfer from animals…”
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Active Components of Essential Oils as Anti-Obesity Potential Drugs Investigated by in Silico Techniques by Costa, Giosuè, Gidaro, Maria Concetta, Vullo, Daniela, Supuran, Claudiu T, Alcaro, Stefano

“…In this study, for the first time, we have considered essential oils (EOs) as possible resources of carbonic anhydrase inhibitors (CAIs), in particular against…”
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Targeting SARS-CoV‑2 Main Protease: A Successful Story Guided by an In Silico Drug Repurposing Approach by Ambrosio, Francesca Alessandra, Costa, Giosuè, Romeo, Isabella, Esposito, Francesca, Alkhatib, Mohammad, Salpini, Romina, Svicher, Valentina, Corona, Angela, Malune, Paolo, Tramontano, Enzo, Ceccherini-Silberstein, Francesca, Alcaro, Stefano, Artese, Anna

“…The SARS-CoV-2 main protease (Mpro) is a crucial enzyme for viral replication and has been considered an attractive drug target for the treatment of COVID-19…”
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Kaempferol as Selective Human MAO‑A Inhibitor: Analytical Detection in Calabrian Red Wines, Biological and Molecular Modeling Studies by Gidaro, Maria Concetta, Astorino, Christian, Petzer, Anél, Carradori, Simone, Alcaro, Francesca, Costa, Giosuè, Artese, Anna, Rafele, Giancarlo, Russo, Francesco M, Petzer, Jacobus P, Alcaro, Stefano

“…The purpose of this work was to determine the kaempferol content in three red wines of Calabria, a southern Italian region with a great number of certified…”
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Identification of Compounds Targeting HuD. Another Brick in the Wall of Neurodegenerative Disease Treatment by Ambrosio, Francesca Alessandra, Coricello, Adriana, Costa, Giosuè, Lupia, Antonio, Micaelli, Mariachiara, Marchesi, Nicoletta, Sala, Federico, Pascale, Alessia, Rossi, Daniela, Vasile, Francesca, Alcaro, Stefano, Collina, Simona

“…ELAV-like (ELAVL) RNA-binding proteins play a pivotal role in post-transcriptional processes, and their dysregulation is involved in several pathologies. This…”
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Mediterranean products as promising source of multi-target agents in the treatment of metabolic syndrome by Bagetta, Donatella, Maruca, Annalisa, Lupia, Antonio, Mesiti, Francesco, Catalano, Raffaella, Romeo, Isabella, Moraca, Federica, Ambrosio, Francesca Alessandra, Costa, Giosuè, Artese, Anna, Ortuso, Francesco, Alcaro, Stefano, Rocca, Roberta

“…Alteration of nutritional habits play an essential role on the risk of developing Metabolic Syndrome (MetS). Several epidemiological studies have shown that…”
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Folding intermediate states of the parallel human telomeric G-quadruplex DNA explored using Well-Tempered Metadynamics by Rocca, Roberta, Palazzesi, Ferruccio, Amato, Jussara, Costa, Giosuè, Ortuso, Francesco, Pagano, Bruno, Randazzo, Antonio, Novellino, Ettore, Alcaro, Stefano, Moraca, Federica, Artese, Anna

“…An increasingly comprehension of the folding intermediate states of DNA G-quadruplexes (G4s) is currently an important scientific challenge, especially for the…”
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Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity by Dichiara, Maria, Ambrosio, Francesca Alessandra, Lee, Sang Min, Ruiz-Cantero, M. Carmen, Lombino, Jessica, Coricello, Adriana, Costa, Giosuè, Shah, Dhara, Costanzo, Giuliana, Pasquinucci, Lorella, Son, Kyung No, Cosentino, Giuseppe, González-Cano, Rafael, Marrazzo, Agostino, Aakalu, Vinay Kumar, Cobos, Enrique J., Alcaro, Stefano, Amata, Emanuele

“…The design and synthesis of a series of 2,7-diazaspiro[4.4]­nonane derivatives as potent sigma receptor (SR) ligands, associated with analgesic activity, are…”
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In Silico-Guided Rational Drug Design and Synthesis of Novel 4‑(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists by Romeo, Isabella, Brizzi, Antonella, Pessina, Federica, Ambrosio, Francesca Alessandra, Aiello, Francesca, Belardo, Carmela, Carullo, Gabriele, Costa, Giosuè, De Petrocellis, Luciano, Frosini, Maria, Luongo, Livio, Maramai, Samuele, Paolino, Marco, Moriello, Aniello Schiano, Mugnaini, Claudia, Scorzelli, Francesco, Maione, Sabatino, Corelli, Federico, Di Marzo, Vincenzo, Alcaro, Stefano, Artese, Anna

“…We describe an in silico-guided rational drug design and the synthesis of the suggested ligands, aimed at improving the TRPV1-ligand binding properties and the…”
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Natural Agents as Novel Potential Source of Proteasome Inhibitors with Anti-Tumor Activity: Focus on Multiple Myeloma by Ambrosio, Francesca Alessandra, Costa, Giosuè, Gallo Cantafio, Maria Eugenia, Torcasio, Roberta, Trapasso, Francesco, Alcaro, Stefano, Viglietto, Giuseppe, Amodio, Nicola

“…Multiple myeloma (MM) is an aggressive and incurable disease for most patients, characterized by periods of treatment, remission and relapse. The introduction…”
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The Mediterranean Diet as source of bioactive compounds with multi-targeting anti-cancer profile by Maruca, Annalisa, Catalano, Raffaella, Bagetta, Donatella, Mesiti, Francesco, Ambrosio, Francesca Alessandra, Romeo, Isabella, Moraca, Federica, Rocca, Roberta, Ortuso, Francesco, Artese, Anna, Costa, Giosuè, Alcaro, Stefano, Lupia, Antonio

“…Many bioactive agents have been extracted from plants or belong to functional foods and have been considered in the treatment of serious and multifactorial…”
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Identification and Characterization of New DNA G‑Quadruplex Binders Selected by a Combination of Ligand and Structure-Based Virtual Screening Approaches by Alcaro, Stefano, Musetti, Caterina, Distinto, Simona, Casatti, Margherita, Zagotto, Giuseppe, Artese, Anna, Parrotta, Lucia, Moraca, Federica, Costa, Giosuè, Ortuso, Francesco, Maccioni, Elias, Sissi, Claudia

“…Nowadays, it has been demonstrated that DNA G-quadruplex arrangements are involved in cellular aging and cancer, thus boosting the discovery of selective…”
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Targeting SARS-CoV-2 nsp13 Helicase and Assessment of Druggability Pockets: Identification of Two Potent Inhibitors by a Multi-Site In Silico Drug Repurposing Approach by Romeo, Isabella, Ambrosio, Francesca Alessandra, Costa, Giosuè, Corona, Angela, Alkhatib, Mohammad, Salpini, Romina, Lemme, Saverio, Vergni, Davide, Svicher, Valentina, Santoro, Maria Mercedes, Tramontano, Enzo, Ceccherini-Silberstein, Francesca, Artese, Anna, Alcaro, Stefano

“…The SARS-CoV-2 non-structural protein 13 (nsp13) helicase is an essential enzyme for viral replication and has been identified as an attractive target for the…”
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C‑6α- vs C‑7α-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure–Activity Relationships by Roleira, Fernanda M. F, Varela, Carla, Amaral, Cristina, Costa, Saul C, Correia-da-Silva, Georgina, Moraca, Federica, Costa, Giosuè, Alcaro, Stefano, Teixeira, Natércia A. A, Tavares da Silva, Elisiário J

“…C-6α and C-7α androstanes were studied to disclose which position among them is more convenient to functionalize to reach superior aromatase inhibition. In the…”
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Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition by Catalogna, Giada, Moraca, Federica, D'Antona, Lucia, Dattilo, Vincenzo, Perrotti, Giuseppe, Lupia, Antonio, Costa, Giosuè, Ortuso, Francesco, Iuliano, Rodolfo, Trapasso, Francesco, Amato, Rosario, Alcaro, Stefano, Perrotti, Nicola

“…Resveratrol (trans-3,4’,5-trihydroxystilbene) is a polyphenolic natural product with a well-known polypharmacological profile that places it among the…”
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Update on SARS-CoV-2 Omicron Variant of Concern and Its Peculiar Mutational Profile by Alkhatib, Mohammad, Salpini, Romina, Carioti, Luca, Ambrosio, Francesca Alessandra, D'Anna, Stefano, Duca, Leonardo, Costa, Giosuè, Bellocchi, Maria Concetta, Piermatteo, Lorenzo, Artese, Anna, Santoro, Maria Mercedes, Alcaro, Stefano, Svicher, Valentina, Ceccherini-Silberstein, Francesca

“…The process of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genetic diversification is still ongoing and has very recently led to the emergence…”
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