Search Results - "Costa, Alberto C.S."

Soluble prion protein and its N-terminal fragment prevent impairment of synaptic plasticity by Aβ oligomers: Implications for novel therapeutic strategy in Alzheimer's disease by Scott-McKean, Jonah J, Surewicz, Krystyna, Choi, Jin-Kyu, Ruffin, Vernon A, Salameh, Ahlam I, Nieznanski, Krzysztof, Costa, Alberto C.S, Surewicz, Witold K

“…Abstract The pathogenic process in Alzheimer's disease (AD) appears to be closely linked to the neurotoxic action of amyloid-β (Aβ) oligomers. Recent studies…”
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Generation of Integration‐Free Induced Pluripotent Stem Cells from Urine‐Derived Cells Isolated from Individuals with Down Syndrome by M. Lee, Young, Zampieri, Bruna L., Scott‐McKean, Jonah J., Johnson, Mark W., Costa, Alberto C.S.

“…Down syndrome (DS) is a genetic disorder caused by trisomy 21 (T21). Over the past two decades, the use of mouse models has led to significant advances in the…”
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The glutamatergic hypothesis for Down syndrome: the potential use of N-methyl-D-aspartate receptor antagonists to enhance cognition and decelerate neurodegeneration by Costa, Alberto C S

“…Down syndrome (DS) is the most common genetically defined cause of intellectual disability and accounts for over 50% of the cases of Alzheimer-type dementia in…”
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Ultrasonic vocalizations during male–female interaction in the mouse model of Down syndrome Ts65Dn by Zampieri, Bruna L, Fernandez, Fabian, Pearson, Jennifer N, Stasko, Melissa R, Costa, Alberto C.S

“…Abstract Down syndrome (DS) is the leading cause of genetically defined intellectual disability. Although speech and language impairments are salient features…”
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Sustained hippocampal IL-1β overexpression impairs contextual and spatial memory in transgenic mice by Hein, Amy M, Stasko, Melissa R, Matousek, Sarah B, Scott-McKean, Jonah J, Maier, Steven F, Olschowka, John A, Costa, Alberto C.S, O’Banion, M. Kerry

“…Abstract Neuroinflammatory conditions such as traumatic brain injury, aging, Alzheimer’s disease, and Down syndrome are often associated with cognitive…”
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Medical vulnerability of individuals with Down syndrome to severe COVID-19–data from the Trisomy 21 Research Society and the UK ISARIC4C survey by Hüls, Anke, Costa, Alberto C.S., Dierssen, Mara, Baksh, R. Asaad, Bargagna, Stefania, Baumer, Nicole T., Brandão, Ana Claudia, Carfi, Angelo, Carmona-Iragui, Maria, Chicoine, Brian Allen, Ghosh, Sujay, Lakhanpaul, Monica, Manso, Coral, Mayer, Miguel-Angel, Ortega, Maria del Carmen, de Asua, Diego Real, Rebillat, Anne-Sophie, Russell, Lauren Ashley, Sgandurra, Giuseppina, Valentini, Diletta, Sherman, Stephanie L., Strydom, Andre

“…Health conditions, immune dysfunction, and premature aging associated with trisomy 21 (Down syndrome, DS) may impact the clinical course of COVID-19. The T21RS…”
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Atypical electrophysiological and behavioral responses to diazepam in a leading mouse model of Down syndrome by Victorino, Daniella B., Pinheiro, Daniel J. L. L., Scott-McKean, Jonah J., Barker, Sarah, Stasko, Melissa R., Faber, Jean, Scorza, Carla A., Costa, Alberto C. S.

“…Mounting evidence implicates dysfunctional GABA A R-mediated neurotransmission as one of the underlying causes of learning and memory deficits observed in the…”
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Toward the Identification of Neurophysiological Biomarkers for Alzheimer's Disease in Down Syndrome: A Potential Role for Cross-Frequency Phase-Amplitude Coupling Analysis by Victorino, Daniella B, Faber, Jean, Pinheiro, Daniel J L L, Scorza, Fulvio A, Almeida, Antônio C G, Costa, Alberto C S, Scorza, Carla A

“…Cross-frequency coupling (CFC) mechanisms play a central role in brain activity. Pathophysiological mechanisms leading to many brain disorders, such as…”
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Pharmacological Modulation of Three Modalities of CA1 Hippocampal Long-Term Potentiation in the Ts65Dn Mouse Model of Down Syndrome by Surewicz, Witold K., Johnson, Mark W., Surewicz, Krystyna, Roque, Adriano L., Scott-McKean, Jonah J., Costa, Alberto C. S.

“…The Ts65Dn mouse is the most studied animal model of Down syndrome. Past research has shown a significant reduction in CA1 hippocampal long-term potentiation…”
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An assessment of the vestibulo-ocular reflex (VOR) in persons with Down syndrome by Costa, Alberto C. S.

“…Down syndrome (DS), the most common genetically defined cause of intellectual disability, is the phenotypic consequence of a supernumerary chromosome 21…”
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An assessment of optokinetic nystagmus (OKN) in persons with down syndrome by Costa, Alberto C. S.

“…Down syndrome (DS), the most common genetically defined cause of intellectual disability, is the phenotypic consequence of a supernumerary chromosome 21…”
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Noninvasive assessment of autonomic modulation of heart rate variability in the Ts65Dn mouse model of Down syndrome: A proof of principle study by Roque, Adriano L., Johnson, Mark W., Stasko, Melissa R., Abreu, Luiz C., Silva, Talita D., Costa, Alberto C.S.

“…Introduction The Ts65Dn mouse is the most widely used animal model of Down syndrome (DS). Differences in autonomic regulation of heart rate variability (HRV)…”
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Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome by Stasko, Melissa R, Costa, Alberto C.S

“…The Ts65Dn mouse is the most studied and genetically the most complete animal model of Down syndrome (DS) available. These mice display many DS-like features,…”
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Motor dysfunction in a mouse model for Down syndrome by Costa, Alberto C.S, Walsh, Kathryn, Davisson, Muriel T

“…Motor deficits are among the most frequently occurring features of Down syndrome (DS). Individuals with DS exhibit disturbances in the dynamics of movement…”
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Hypothermic responses to 8-OH-DPAT in the Ts65Dn mouse model of Down syndrome by Stasko, Melissa R, Scott-McKean, Jonah J, Costa, Alberto C.S

“…Recently, we have demonstrated that potassium channels containing G-protein-activated potassium channel 2 (GIRK2) subunits play a significant role in…”
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Prospects for Improving Brain Function in Individuals with Down Syndrome by Costa, Alberto C. S., Scott-McKean, Jonah J.

“…Down syndrome (DS), which results from an extra copy of chromosome 21 (trisomy 21), is the most common genetically defined cause of intellectual disability…”
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Safety, efficacy, and tolerability of memantine for cognitive and adaptive outcome measures in adolescents and young adults with Down syndrome: a randomised, double-blind, placebo-controlled phase 2 trial by Costa, Alberto C S, Brandão, Ana C, Boada, Richard, Barrionuevo, Veridiana L, Taylor, Hudson G, Roth, Elizabeth, Stasko, Melissa R, Johnson, Mark W, Assir, Fernanda F, Roberto, Maria P, Salmona, Patrícia, Abreu-Silveira, Guilherme, Bederman, Ilya, Prendergast, Erin, Hüls, Anke, Abrishamcar, Sarina, Mustacchi, Zan, Scheidemantel, Thomas, Roizen, Nancy J, Ruedrich, Stephen

“…Down syndrome is a chromosomal disorder with considerable neurodevelopmental impact and neurodegenerative morbidity. In a pilot trial in young adults with Down…”
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Quantitative Analysis of Retinal Structure and Function in Two Chromosomally Altered Mouse Models of Down Syndrome by Victorino, Daniella B, Scott-McKean, Jonah J, Johnson, Mark W, Costa, Alberto C S

“…Ophthalmic disorders are among the most prevalent Down syndrome (DS) comorbidities. Therefore, when studying mouse models of DS, ignoring how vision is…”
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Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome by Ahmed, Md Mahiuddin, Dhanasekaran, A Ranjitha, Block, Aaron, Tong, Suhong, Costa, Alberto C S, Stasko, Melissa, Gardiner, Katheleen J

“…Down syndrome (DS) is caused by an extra copy of human chromosome 21 (Hsa21). Although it is the most common genetic cause of intellectual disability (ID),…”
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Acute Injections of the NMDA Receptor Antagonist Memantine Rescue Performance Deficits of the Ts65Dn Mouse Model of Down Syndrome on a Fear Conditioning Test by COSTA, Alberto C. S, SCOTT-MCKEAN, Jonah J, STASKO, Melissa R

“…Individuals with Down syndrome (DS) and Ts65Dn mice (a major animal model of DS) carry an extra copy of the DSCR1 (Down Syndrome Critical Region 1) gene, which…”
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