Kaposi's sarcoma in persons living with HIV/AIDS: a case series in a tertiary referral hospital

Kaposi's sarcoma (KS) is a rare neoplasm with indolent progression. Since 1981, the Kaposi's sarcoma epidemic has increased as co-infection with HIV. The study aimed to identify the clinical and demographic characteristics and therapeutic approaches in HIV/AIDS patients in a regional refer...

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Published in:	Anais brasileiros de dermatología Vol. 93; no. 4; pp. 524 - 528
Main Authors:	Pires, Carla Andréa Avelar, Noronha, Marcos Antonio Neves, Monteiro, Julius Caesar Mendes Soares, Costa, Albert Luiz Costa da, Abreu Júnior, José Maria de Castro
Format:	Journal Article
Language:	English
Published:	Spain Sociedade Brasileira de Dermatologia 01-07-2018
Subjects:	Acquired immunodeficiency syndrome Adolescent Adult AIDS-Related Opportunistic Infections - drug therapy AIDS-Related Opportunistic Infections - epidemiology AIDS-Related Opportunistic Infections - pathology Antiretroviral Therapy, Highly Active Brazil - epidemiology Cross-Sectional Studies DERMATOLOGY Female HIV Human herpesvirus 8 Humans Investigation Kaposi’s sarcoma Male Middle Aged Retrospective Studies Sarcoma, Kaposi - drug therapy Sarcoma, Kaposi - epidemiology Sarcoma, Kaposi - pathology Socioeconomic Factors Tertiary Care Centers Young Adult Human herpesvirus 8 HIV Kaposi’s sarcoma Acquired immunodeficiency syndrome
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Summary:	Kaposi's sarcoma (KS) is a rare neoplasm with indolent progression. Since 1981, the Kaposi's sarcoma epidemic has increased as co-infection with HIV. The study aimed to identify the clinical and demographic characteristics and therapeutic approaches in HIV/AIDS patients in a regional referral hospital. We analyzed the medical records of 51 patients with histopathological diagnosis of Kaposi's sarcoma hospitalized at Hospital Universitário João de Barros Barreto (HUJBB) from 2004 to 2015. The study sample consisted of individuals 15 to 44 years of age (80.4%), male (80.4%), single (86.3%), and residing in Greater Metropolitan Belém, Pará State, Brazil. The primary skin lesions identified at diagnosis were violaceous macules (45%) and violaceous papules (25%). Visceral involvement was seen in 62.7%, mainly affecting the stomach (75%). The most frequent treatment regimen was 2 NRTI + NNRTI, and 60.8% were referred to chemotherapy. We assumed that more patients had been admitted to hospital without histopathological confirmation or with pathology reports from other services, so that the current study probably underestimated the number of KS cases. Although the cutaneous manifestations in most of these patients were non-exuberant skin lesions like macules and papules, many already showed visceral involvement. Meticulous screening of these patients is thus mandatory, even if the skin lesions are subtle and localized.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0365-0596 1806-4841 1806-4841
DOI:	10.1590/abd1806-4841.20186978