Search Results - "Cossio, Unai"

COSAN-stabilised omega-3 oil-in-water nanoemulsions to prolong lung residence time for poorly water soluble drugs by Navascuez, Marcos, Dupin, Damien, Grande, Hans-Jürgen, Gómez-Vallejo, Vanessa, Loinaz, Iraida, Cossío, Unai, Llop, Jordi

“…Herein, we report on the capacity of the amphiphilic inorganic anion cobalt bis(dicarbollide) to stabilise oil-in-water nanoemulsions (NEs). The resulting NEs…”
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Unpredictable Nanoparticle Retention in Commonly Used Plastic Syringes Introduces Dosage Uncertainties That May Compromise the Accuracy of Nanomedicine and Nanotoxicology Studies by Holzwarth, Uwe, Cossío, Unai, Llop, Jordi, Kreyling, Wolfgang G.

“…In recent animal experiments with suspensions of radiolabeled TiO 2 nanoparticles large and highly variable radioactivity fractions were retained in disposable…”
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Preclinical evaluation of aerosol administration systems using Positron Emission Tomography by Cossío, Unai, Gómez-Vallejo, Vanessa, Flores, María, Gañán-Calvo, Braulio, Jurado, Gloria, Llop, Jordi

“…[Display omitted] Pulmonary administration of drugs has recently gained attention because it exhibits numerous advantages compared to oral or intravenous…”
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Medical Imaging for the Tracking of Micromotors by Vilela, Diana, Cossío, Unai, Parmar, Jemish, Martínez-Villacorta, Angel M, Gómez-Vallejo, Vanessa, Llop, Jordi, Sánchez, Samuel

“…Micro/nanomotors are useful tools for several biomedical applications, including targeted drug delivery and minimally invasive microsurgeries. However, major…”
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Three-Dimensional Conductive Scaffolds as Neural Prostheses Based on Carbon Nanotubes and Polypyrrole by Alegret, Nuria, Dominguez-Alfaro, Antonio, González-Domínguez, Jose M, Arnaiz, Blanca, Cossío, Unai, Bosi, Susanna, Vázquez, Ester, Ramos-Cabrer, Pedro, Mecerreyes, David, Prato, Maurizio

“…Three-dimensional scaffolds for cellular organization need to enjoy a series of specific properties. On the one hand, the morphology, shape and porosity are…”
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Gold Nanoparticles as Boron Carriers for Boron Neutron Capture Therapy: Synthesis, Radiolabelling and In vivo Evaluation by Pulagam, Krishna R, Gona, Kiran B, Gómez-Vallejo, Vanessa, Meijer, Jan, Zilberfain, Carolin, Estrela-Lopis, Irina, Baz, Zuriñe, Cossío, Unai, Llop, Jordi

“…: Boron Neutron Capture Therapy (BNCT) is a binary approach to cancer therapy that requires accumulation of boron atoms preferentially in tumour cells. This…”
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In Vivo Evaluation of Multifunctional Gold Nanorods for Boron Neutron Capture and Photothermal Therapies by Pulagam, Krishna R, Henriksen-Lacey, Malou, B. Uribe, Kepa, Renero-Lecuna, Carlos, Kumar, Jatish, Charalampopoulou, Alexandra, Facoetti, Angelica, Protti, Nicoletta, Gómez-Vallejo, Vanessa, Baz, Zuriñe, Kumar, Vished, Sánchez-Iglesias, Ana, Altieri, Saverio, Cossío, Unai, Di Silvio, Desire, Martínez-Villacorta, Angel M, Ruiz de Angulo, Ane, Rejc, Luka, Liz-Marzán, Luis M, Llop, Jordi

“…The incidence and mortality of cancer demand more innovative approaches and combination therapies to increase treatment efficacy and decrease off-target side…”
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Antimicrobial Peptide-Loaded Nanoparticles as Inhalation Therapy for Pseudomonas aeruginosa Infections by Falciani, Chiara, Zevolini, Fabrizia, Brunetti, Jlenia, Riolo, Giulia, Gracia, Raquel, Marradi, Marco, Loinaz, Iraida, Ziemann, Christina, Cossío, Unai, Llop, Jordi, Bracci, Luisa, Pini, Alessandro

“…Antibiotic-resistant bacteria kill 25,000 people every year in the EU. Patients subject to recurrent lung infections are the most vulnerable to severe or even…”
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Assessment of Regional Lung Ventilation with Positron Emission Tomography Using the Radiofluorinated Gas [18F]SF6: Application to an Animal Model of Impaired Ventilation by Passannante, Rossana, Gómez-Vallejo, Vanessa, Cossío, Unai, Ruiz-Cabello, Jesús, Lekuona, Aitor, Salinas, Victor, Amado-Rodríguez, Laura, Albaiceta, Guillermo M., Martín, Abraham, Rejc, Luka, Llop, Jordi

“…Purpose Clinical ventilation studies are primarily performed with computerized tomography (CT) and more often with single-photon emission Computerized…”
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Multimodal imaging of the role of hyperglycemia following experimental subarachnoid hemorrhage by Joya, Ana, Plaza-García, Sandra, Padro, Daniel, Aguado, Laura, Iglesias, Leyre, Garbizu, Maider, Gómez-Vallejo, Vanessa, Laredo, Carlos, Cossío, Unai, Torné, Ramon, Amaro, Sergio, Planas, Anna M, Llop, Jordi, Ramos-Cabrer, Pedro, Justicia, Carles, Martín, Abraham

“…Hyperglycemia has been linked to worsening outcomes after subarachnoid hemorrhage (SAH). Nevertheless, the mechanisms involved in the pathogenesis of SAH have…”
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Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD by Rios, Xabier, Gómez-Vallejo, Vanessa, Martín, Abraham, Cossío, Unai, Morcillo, Miguel Ángel, Alemi, Mobina, Cardoso, Isabel, Quintana, Jordi, Jiménez-Barbero, Jesús, Cotrina, Ellen Y., Valencia, Gregorio, Arsequell, Gemma, Llop, Jordi

“…It is well settled that the amyloidogenic properties of the plasma protein transporter transthyretin (TTR) can be modulated by compounds that stabilize its…”
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Tailored Methodology Based on Vapor Phase Polymerization to Manufacture PEDOT/CNT Scaffolds for Tissue Engineering by Dominguez-Alfaro, Antonio, Alegret, Nuria, Arnaiz, Blanca, González-Domínguez, Jose M, Martin-Pacheco, Ana, Cossío, Unai, Porcarelli, Luca, Bosi, Susanna, Vázquez, Ester, Mecerreyes, David, Prato, Maurizio

“…Three-dimensional (3D) scaffolds with tailored stiffness, porosity, and conductive properties are particularly important in tissue engineering for…”
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Longitudinal evaluation of neuroinflammation and oxidative stress in a mouse model of Alzheimer disease using positron emission tomography by Rejc, Luka, Gómez-Vallejo, Vanessa, Joya, Ana, Arsequell, Gemma, Egimendia, Ander, Castellnou, Pilar, Ríos-Anglada, Xabier, Cossío, Unai, Baz, Zuriñe, Iglesias, Leyre, Capetillo-Zarate, Estibaliz, Ramos-Cabrer, Pedro, Martin, Abraham, Llop, Jordi

“…Validation of new biomarkers of Alzheimer disease (AD) is crucial for the successful development and implementation of treatment strategies. Additional to…”
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Immuno-PET Imaging and Pharmacokinetics of an Anti-CEA scFv-based Trimerbody and Its Monomeric Counterpart in Human Gastric Carcinoma-Bearing Mice by Rios, Xabier, Compte, Marta, Gómez-Vallejo, Vanessa, Cossío, Unai, Baz, Zuriñe, Morcillo, Miguel Ángel, Ramos-Cabrer, Pedro, Alvarez-Vallina, Luis, Llop, Jordi

“…Monoclonal antibodies (mAbs) are currently used as therapeutic agents in different types of cancer. However, mAbs and antibody fragments developed so far show…”
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Therapeutic Efficacy of Novel Antimicrobial Peptide AA139-Nanomedicines in a Multidrug-Resistant Klebsiella pneumoniae Pneumonia-Septicemia Model in Rats by van der Weide, Hessel, Cossío, Unai, Gracia, Raquel, Te Welscher, Yvonne M, Ten Kate, Marian T, van der Meijden, Aart, Marradi, Marco, Ritsema, Jeffrey A S, Vermeulen-de Jongh, Denise M C, Storm, Gert, Goessens, Wil H F, Loinaz, Iraida, van Nostrum, Cornelus F, Llop, Jordi, Hays, John P, Bakker-Woudenberg, Irma A J M

“…Antimicrobial peptides (AMPs) have seen limited clinical use as antimicrobial agents, largely due to issues relating to toxicity, short biological half-life,…”
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Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease by Rejc, Luka, Gómez-Vallejo, Vanessa, Joya, Ana, Moreno, Oscar, Egimendia, Ander, Castellnou, Pilar, Ríos-Anglada, Xabier, Cossío, Unai, Baz, Zuriñe, Passannante, Rossana, Tobalina-Larrea, Ignacio, Ramos-Cabrer, Pedro, Giralt, Albert, Sastre, Magdalena, Capetillo-Zarate, Estibaliz, Košak, Urban, Knez, Damijan, Gobec, Stanislav, Marder, Mariel, Martin, Abraham, Llop, Jordi

“…The increase in butyrylcholinesterase (BChE) activity in the brain of Alzheimer disease (AD) patients and animal models of AD position this enzyme as a…”
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In vivo multimodal imaging of adenosine A1 receptors in neuroinflammation after experimental stroke by Joya, Ana, Ardaya, María, Montilla, Alejandro, Garbizu, Maider, Plaza-García, Sandra, Gómez-Vallejo, Vanessa, Padro, Daniel, Gutiérrez, Juan José, Rios, Xabier, Ramos-Cabrer, Pedro, Cossío, Unai, Pulagam, Krishna R, Higuchi, Makoto, Domercq, María, Cavaliere, Fabio, Matute, Carlos, Llop, Jordi, Abraham, Martín

“…Adenosine A1 receptors (A1ARs) are promising imaging biomarkers and targets for the treatment of stroke. Nevertheless, the role of A1ARs on ischemic damage and…”
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Pulmonary Administration: Strengthening the Value of Therapeutic Proximity by Videira, Mafalda A, Llop, Jordi, Sousa, Carolina, Kreutzer, Bruna, Cossío, Unai, Forbes, Ben, Vieira, Isabel, Gil, Nuno, Silva-Lima, Beatriz

“…In recent years inhaled systems have shown momentum as patient-personalized therapies emerge. A significant improvement in terms of therapeutic efficacy and/or…”
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Synthesis of Chromen[4,3-b]pyrrolidines by Intramolecular 1,3-Dipolar Cycloadditions of Azomethine Ylides: An Experimental and Computational Assessment of the Origin of Stereocontrol by Costa, Paulo R. R., Sansano, José M., Cossío, Unai, Barcellos, Julio C. F., Dias, Ayres G., Nájera, Carmen, Arrieta, Ana, de Cózar, Abel, Cossío, Fernando P.

“…Azomethine ylides, generated from imine‐derived O‐cinnamyl or O‐crotonyl salicylaldeyde and α‐amino acids, undergo intramolecular 1,3‐dipolar cycloaddition,…”
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Pharmacokinetic Evaluation of New Drugs Using a Multi-Labelling Approach and PET Imaging: Application to a Drug Candidate with Potential Application in Neuromuscular Disorders by Passannante, Rossana, Gómez-Vallejo, Vanessa, Sagartzazu-Aizpurua, Maialen, Vignau Arsuaga, Laura, Marco-Moreno, Pablo, Aldanondo, Garazi, Vallejo-Illarramendi, Ainara, Aguiar, Pablo, Cossío, Unai, Martín, Abraham, Bergare, Jonas, Kingston, Lee, Elmore, Charles S, Morcillo, Miguel Angel, Ferrón, Pablo, Aizpurua, Jesus M, Llop, Jordi

“…The determination of pharmacokinetic properties of new chemical entities is a key step in the process of drug development. Positron emission tomography (PET)…”
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