Search Results - "Cosner, C."

Palladium- and Nickel-Catalyzed Alkenylation of Enolates by Ankner, Tobias, Cosner, Casey C., Helquist, Paul

“…Transition‐metal‐catalyzed alkenylation of enolates provides a direct method to synthesize broadly useful β,γ‐unsaturated carbonyl compounds from the…”
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The effects of human movement on the persistence of vector-borne diseases by Cosner, C., Beier, J.C., Cantrell, R.S., Impoinvil, D., Kapitanski, L., Potts, M.D., Troyo, A., Ruan, S.

“…With the recent resurgence of vector-borne diseases due to urbanization and development there is an urgent need to understand the dynamics of vector-borne…”
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Effects of dispersal rates in a two-stage reaction-diffusion system by Cantrell, R. S., Cosner, C., Salako, R. B.

“…It is well known that in reaction-diffusion models for a single unstructured population in a bounded, static, heterogeneous environment, slower diffusion is…”
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Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts by Pipalia, Nina H, Cosner, Casey C, Huang, Amy, Chatterjee, Anamitra, Bourbon, Pauline, Farley, Nathan, Helquist, Paul, Wiest, Olaf, Maxfield, Frederick R

“…Niemann-Pick type C (NPC) disease is predominantly caused by mutations in the NPC1 protein that affect intracellular cholesterol trafficking and cause…”
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Thiadiazole Carbamates: Potent Inhibitors of Lysosomal Acid Lipase and Potential Niemann−Pick Type C Disease Therapeutics by Rosenbaum, Anton I, Cosner, Casey C, Mariani, Christopher J, Maxfield, Frederick R, Wiest, Olaf, Helquist, Paul

“…Niemann−Pick type C (NPC) disease is a lysosomal storage disorder characterized at the cellular level by abnormal accumulation of cholesterol and other lipids…”
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Evolution of Concise and Flexible Synthetic Strategies for Trichostatic Acid and the Potent Histone Deacetylase Inhibitor Trichostatin A by Cosner, Casey C., Bhaskara Reddy Iska, Vijaya, Chatterjee, Anamitra, Markiewicz, John T., Corden, Steven J., Löfstedt, Joakim, Ankner, Tobias, Richer, Joshua, Hulett, Tyler, Schauer, Douglas J., Wiest, Olaf, Helquist, Paul

“…(R)‐(+)‐Trichostatic acid and (R)‐(+)‐trichostatin A (TSA) are natural products that have attracted considerable attention in the field of epigenetic…”
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A model for the coupling of the Greater Bairam and local environmental factors in promoting Rift-Valley Fever epizootics in Egypt by Gil, H, Qualls, W.A, Cosner, C, DeAngelis, D.L, Hassan, A, Gad, A.M, Ruan, S, Cantrell, S.R, Beier, J.C

“…Abstract Objectives Rift-Valley Fever (RVF) is a zoonotic mosquito-borne disease in Africa and the Arabian Peninsula. Drivers for this disease vary by region…”
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Selective Oxidation of Benzylic and Allylic Alcohols Using Mn(OAc)3/Catalytic 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone by Cosner, Casey C, Cabrera, Pablo J, Byrd, Katherine M, Thomas, Asia M. Adams, Helquist, Paul

“…A practical, chemoselective oxidation of alcohols employing catalytic quantities of DDQ as the oxidant and Mn(OAc)3 as the co-oxidant is described…”
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Diffusion Models for Population Dynamics Incorporating Individual Behavior at Boundaries: Applications to Refuge Design by Cantrell, R.S., Cosner, C.

“…We construct models for dispersal of a population which incorporate the response of individuals to interfaces between habitat types. The models are based on…”
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Concise, Convergent Syntheses of (±)-Trichostatin A Utilizing a Pd-Catalyzed Ketone Enolate α-Alkenylation Reaction by Cosner, Casey C, Helquist, Paul

“…Two concise, convergent syntheses of (±)-trichostatin A (1), a potent histone deacetylase inhibitor, have been accomplished. The key step in both is a…”
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The effects of spatial heterogeneity in population dynamics by CANTRELL, R. S, COSNER, C

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How Predator Incursions Affect Critical Patch Size: The Role of the Functional Response by Cantrell, Robert Stephen, Cosner, Chris, Fagan, William F.

“…Understanding the impact of habitat edges provides a key to deciphering how community dynamics change as functions of habitat structure and spatial scale…”
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Deriving reaction-diffusion models in ecology from interacting particle systems by Cantrell, R S, Cosner, C

“…We use a scaling procedure based on averaging Poisson distributed random variables to derive population level models from local models of interactions between…”
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Synthesis and evaluation of analogs of 5′-(((Z)-4-amino-2-butenyl)methylamino)-5′-deoxyadenosine (MDL 73811, or AbeAdo) – An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity by Brockway, Anthony J., Volkov, Oleg A., Cosner, Casey C., MacMillan, Karen S., Wring, Stephen A., Richardson, Thomas E., Peel, Michael, Phillips, Margaret A., De Brabander, Jef K.

“…[Display omitted] We describe our efforts to improve the pharmacokinetic properties of a mechanism-based suicide inhibitor of the polyamine biosynthetic enzyme…”
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Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells by Pearson, Gemma L., Mellett, Natalie, Chu, Kwan Yi, Cantley, James, Davenport, Aimee, Bourbon, Pauline, Cosner, Casey C., Helquist, Paul, Meikle, Peter J., Biden, Trevor J.

“…Aims/hypothesis Lipolytic breakdown of endogenous lipid pools in pancreatic beta cells contributes to glucose-stimulated insulin secretion (GSIS) and is…”
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A dynamic model for the ideal-free distribution as a partial differential equation by Cosner, Chris

“…One of the major approaches to understanding spatial effects in ecology and population dynamics is the use of analytic models. Some types of analytic models…”
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Investigation of N-Aryl-3-alkylidenepyrrolinones as Potential Niemann−Pick Type C Disease Therapeutics by Cosner, Casey C, Markiewicz, John T, Bourbon, Pauline, Mariani, Christopher J, Wiest, Olaf, Rujoi, Madalina, Rosenbaum, Anton I, Huang, Amy Y, Maxfield, Frederick R, Helquist, Paul

“…A five-step synthesis of an array of N-aryl-3-alkylidenepyrrolinones, which are potential Niemann−Pick type C (NPC) disease therapeutics, is described. The…”
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Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay by Volkov, Oleg A, Cosner, Casey C, Brockway, Anthony J, Kramer, Martin, Booker, Michael, Zhong, Shihua, Ketcherside, Ariel, Wei, Shuguang, Longgood, Jamie, McCoy, Melissa, Richardson, Thomas E, Wring, Stephen A, Peel, Michael, Klinger, Jeffrey D, Posner, Bruce A, De Brabander, Jef K, Phillips, Margaret A

“…Human African trypanosomiasis (HAT) is a fatal infectious disease caused by the eukaryotic pathogen Trypanosoma brucei (Tb). Available treatments are difficult…”
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On the Dynamics of Predator–Prey Models with the Beddington–DeAngelis Functional Response by Cantrell, Robert Stephen, Cosner, Chris

“…The dynamics of predator–prey models with the Beddington–DeAngelis functional response are analyzed, primarily from the viewpoint of permanence (uniform…”
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Models for Predator-Prey Systems at Multiple Scales by Cantrell, R. S., Cosner, C.

“…Spatially explicit models are constructed for predator dispersal, predator-prey interactions, and prey dispersal and population dynamics in a system where the…”
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