Search Results - "Cosme, Karelia"

Preliminary safety assessment of CIGB-210, an investigational peptide for HIV infection by Ramírez-Suárez, Anna C, Paneque-Guerrero, Taimi, Casillas-Casanova, Dionne, Cosme, Karelia, Bacardí, Dania, Duarte, Carlos A, Ancízar, Julio, Brown, Emma, Castro, Jorge, Suárez-Alba, José, Garay, Hilda, Pereira, Karla, Fernández-Ortega, Celia

“…Current human immunodeficiency virus treatments need to be periodically administered lifelong. In this study we assess the effect of repeated doses of an…”
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Viremia and antibody response in green monkeys (Chlorocebus aethiops sabaeus) infected with dengue virus type 2: A potential model for vaccine testing by Martín, Jorge, Hermida, Lisset, Castro, Jorge, Lazo, Laura, Martínez, Rafael, Gil, Lázaro, Romero, Yaremis, Puente, Pedro, Zaragoza, Santiago, Cosme, Karelia, Guzmán, María G., Cardosa, Jane, Guillén, Gerardo

“…ABSTRACT The increasingly limited availability and high cost of the hitherto most commonly used monkey species in dengue vaccine research has augmented the…”
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Antigenicity and Immunogenicity of a Synthetic Oligosaccharide-Protein Conjugate Vaccine against Haemophilus influenzae Type b by FERNANDEZ-SANTANA, V, CARDOSO, Félix, FIGUEROA, Ignacio, CHANG, Janoi, TOLEDO, Maria E, MUSACCHIO, Alexis, HERNANDEZ, Ibis, IZQUIERDO, Mabel, COSME, Karelia, ROY, Rene, VEREZ-BENCOMO, V, RODRIGUEZ, Arlene, CARMENATE, Tania, PENA, Luis, VALDES, Yuri, HARDY, Eugenio, MAWAS, Fatme, HEYNNGNEZZ, Lazaro, RODRIGUEZ, Maria C

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Vaccine CIGB 247 is potentially safe for use as a novel therapeutic vaccine against cancer in Chlorocebus aethiops monkeys by Castro, Jorge, Puente, Pedro, Martínez, Rafael, Hernández, Alexander, Morera, Yanelys, Martínez, Leticia, Aldana, Lizet, Valdés, Iris, Ayala, Marta, Cosme, Karelia

“…CIGB 247 is a novel cancer therapeutic vaccine based on human vascular endothelial growth factor (VEGF) variant molecule as antigen, in combination with a…”
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A Synthetic Conjugate Polysaccharide Vaccine against Haemophilus Influenzae Type B by Verez-Bencomo, V., Fernández-Santana, V., Hardy, Eugenio, Toledo, Maria E., Rodríguez, Maria C., Heynngnezz, Lazaro, Rodriguez, Arlene, Baly, Alberto, Herrera, Luis, Izquierdo, Mabel, Villar, Annette, Valdés, Yury, Cosme, Karelia, Deler, Mercedes L., Montane, Manuel, Garcia, Ernesto, Ramos, Alexis, Aguilar, Aristides, Medina, Ernesto, Toraño, Gilda, Sosa, Iván, Hernandez, Ibis, Martínez, Raydel, Muzachio, Alexis, Carmenates, Ania, Costa, Lourdes, Cardoso, Félix, Campa, Concepción, Diaz, Manuel, Roy, René

“…Glycoconjugate vaccines provide effective prophylaxis against bacterial infections. To date, however, no commercial vaccine has been available in which the key…”
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Measurement of hematological and serum biochemical normal values of captive housed Chlorocebus aethiops sabaeus monkeys and correlation with the age by Castro, Jorge, Puente, Pedro, Martínez, Rafael, Hernández, Alexander, Martínez, Leticia, Pichardo, Dagmara, Aldana, Lizet, Valdés, Iris, Cosme, Karelia

“…Background Some factors such as sex, age, and captivity conditions have a direct influence on the normal hematological and serum biochemical parameters of…”
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Safety and Therapeutic Profile of a GnRH-Based Vaccine Candidate Directed to Prostate Cancer. A 10-Year Follow-Up of Patients Vaccinated With Heberprovac by Junco, Jesús A, Rodríguez, Ranfis, Fuentes, Franklin, Baladrón, Idania, Castro, Maria D, Calzada, Lesvia, Valenzuela, Carmen, Bover, Eddy, Pimentel, Eulogio, Basulto, Roberto, Arteaga, Niurka, Cid-Arregui, Angel, Sariol, Francisco, González, Lourdes, Porres-Fong, Liliana, Medina, María, Rodríguez, Ayni, Garay, A Hilda, Reyes, Osvaldo, López, Matilde, de Quesada, Lourdes, Alvarez, Allelin, Martínez, Carolina, Marrero, Marleny, Molero, Guillermo, Guerra, Alfredo, Rosales, Pedro, Capote, Carlos, Acosta, Sahily, Vela, Idania, Arzuaga, Lina, Campal, Ana, Ruiz, Erlán, Rubio, Elier, Cedeño, Pável, Sánchez, María Carmen, Cardoso, Pedro, Morán, Rolando, Fernández, Yairis, Campos, Magalys, Touduri, Henio, Bacardi, Dania, Feria, Indalecio, Ramirez, Amilcar, Cosme, Karelia, Saura, Pedro López, Quintana, Maricel, Muzio, Verena, Bringas, Ricardo, Ayala, Marta, Mendoza, Mario, Fernández, Luis E, Carr, Adriana, Herrera, Luis, Guillén, Gerardo

“…Heberprovac is a GnRH based vaccine candidate containing 2.4 mg of the GnRHm1-TT peptide as the main active principle; 245 μg of the very small size…”
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Antigen dose escalation study of a VEGF-based therapeutic cancer vaccine in non human primates by Morera, Yanelys, Bequet-Romero, Mónica, Ayala, Marta, Pérez, Pedro Puente, Castro, Jorge, Sánchez, Javier, Alba, José Suárez, Ancízar, Julio, Cosme, Karelia, Gavilondo, Jorge V

“…Highlights ► CIGB-247 is a cancer therapeutic, based on recombinant modified VEGF as antigen, in combination with powerful adjuvant VSSP. ► We extend the…”
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CIGB-300, a novel proapoptotic peptide that impairs the CK2 phosphorylation and exhibits anticancer properties both in vitro and in vivo by Perea, Silvio E., Reyes, Osvaldo, Baladron, Idania, Perera, Yasser, Farina, Hernán, Gil, Jeovanis, Rodriguez, Arielis, Bacardi, Dania, Marcelo, Jose L., Cosme, Karelia, Cruz, Marisol, Valenzuela, Carmen, López-Saura, Pedro A., Puchades, Yaquelin, Serrano, Joem M., Mendoza, Osmani, Castellanos, Lila, Sanchez, Aniel, Betancourt, Lazaro, Besada, Vladimir, Silva, Ricardo, López, Ernesto, Falcón, Viviana, Hernández, Ignacio, Solares, Margarita, Santana, Agueda, Díaz, Alina, Ramos, Thelvia, López, Carlos, Ariosa, Juan, González, Luis J., Garay, Hilda, Gómez, Daniel, Gómez, Roberto, Alonso, Daniel F., Sigman, Hugo, Herrera, Luis, Acevedo, Boris

“…Protein Kinase CK2 is a serine-threonine kinase frequently deregulated in many human tumors. Here, we hypothesized that a peptide binder to the CK2…”
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Immunogenicity and some safety features of a VEGF-based cancer therapeutic vaccine in rats, rabbits and non-human primates by Morera, Yanelys, Bequet-Romero, Mónica, Ayala, Marta, Velazco, Jorge Castro, Pérez, Pedro Puente, Alba, Jesús Suárez, Ancizar, Julio, Rodríguez, Meilyn, Cosme, Karelia, Gavilondo, Jorge V

“…Abstract We have developed a cancer vaccine candidate (hereafter denominated CIGB-247), based on recombinant modified human vascular endothelial growth factor…”
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Olive baboons: a non-human primate model for testing dengue virus type 2 replication by Valdés, Iris, Gil, Lázaro, Castro, Jorge, Odoyo, Damián, Hitler, Rikoi, Munene, Elephas, Romero, Yaremis, Ochola, Lucy, Cosme, Karelia, Kariuki, Thomas, Guillén, Gerardo, Hermida, Lisset

“…Summary Objective This study evaluated the use of a non-human primate, the olive baboon ( Papio anubis ), as a model of dengue infection. Olive baboons closely…”
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Establecimiento de un ensayo de potencia in vivo para el antígeno de superficie recombinante del virus de la Hepatitis B, en vacunas monovalentes y combinadas by Izquierdo-López, Mabel, Cosme-Díaz, Karelia, García-Illera, Gerardo, Núñez-Lamotte, Zoe, Martínez-Cuéllar, Yamila, Vega-Simón, Maribel, Costa-Anguiano, Lourdes, Quintana-Esquivel, Marisel, Rosales-Torres, Ileana, Mosqueda-Lobaina, Omar

“…En este trabajo se presenta el establecimiento de un ensayo de potencia en ratones con el objetivo de demostrar el poder inmunogénico del antígeno de…”
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Nepidermina: A new therapeutic alternative in the treatment of patients with diabetic foot safety preclinical evaluation by Cosme, Karelia, Bacardi, Dania, Aldana, Lizet, Berlanga, Jorge, Lopez, Ernesto

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Establishment of an in vivo potency assay for the recombinant hepatit is B surface antigen in monovalent and combined vaccines by Mabel Izquierdo-López, Karelia Cosme-Diaz, Gerardo García-Illera, Zoe Núñez-Lamotte, Yamila Martínez- Cuéllar, Maribel Vega-Simón, Lourdes Costa-Anguiano, Marisel Quintana-Esquivel, Ileana Rosales-Torres, Omar Mosqueda-Lobaina

“…In this paper the development of potency assay in animals (mice) was made, with the objective of demonstrating the immunogenic power of the recombinant…”
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Non-clinical toxicological studies carried out of a new biomolecule with anti tumoural effect by Cosme, Karelia, Bacardi, Dania, Vazquez, Ariel, Suarez, Jose, Perea, Silvio, Aldana, Lizet, Alonso, Daniel, Acevedo, Boris, Herrera, Luis

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Toxicology and biodistribution study of CIGB-230, a DNA vaccine against hepatitis C virus by Bacardí, Dania, Amador-Cañizares, Yalena, Cosme, Karelia, Urquiza, Dioslaida, Suárez, José, Marante, Jeny, Viña, Ariel, Vázquez, Ariel, Concepción, Joel, Pupo, Maylín, Aldana, Lizet, Soria, Yordanka, Romero, Juan, Madrigal, Roberto, Martínez, Leticia, Hernández, Lourdes, González, Idania, Dueñas-Carrera, Santiago

“…CIGB-230, a mixture of a DNA plasmid expressing hepatitis C virus (HCV) structural antigens and a HCV recombinant capsid protein, has demonstrated to elicit…”
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Ratio of HCV structural antigens in protein-based vaccine formulations is critical for functional immune response induction by Martínez-Donato, Gillian, Musacchio, Alexis, Alvarez-Lajonchere, Liz, Acosta-Rivero, Nelson, Amador, Yalena, Guerra, Ivis, Peña, Dilver, Pérez, Angel, Castro, Jorge, Puentes, Pedro, Soria, Yordanka, Cosme, Karelia, Sanchez, Jorge, Dueñas-Carrera, Santiago

“…HCV (hepatitis C virus) infection is among the leading causes of chronic liver disease, but currently there is no vaccine available. Data have accumulated…”
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Safety evaluation of CIGB-500, therapeutic option in the treatment of Acute Myocardium Infarct by Fernández, Dania Bacardi, Díaz, Karelia Cosme, Alba, José Suárez, Bonachea, Ariel Vázquez, Velazco, Lizet Aldana, Acosta, Jorge Berlanga, Noa, Dioslaida Urquiza, Pérez, Lourdes Hernández

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Safety demonstration of multivalent antibody fragment anti-CEA M3 as biomarker by Fernández, Dania Bacardí, Díaz, Karelia Cosme, Velazco, Lizet Aldana, Alba, José Suárez, Bonachea, Ariel Vázquez, Noa, Dioslaida Urquiza, Chamizo, Juan Romero, Sánchez, Lincidio Pérez, Cowley, Jorge Gavilondo, Perez, Lourdes Hernández

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Immunization with a recombinant fowlpox virus expressing a hepatitis C virus core-E I polyprotein variant, protects mice and African green monkeys (Chlorocebus aethiops sabaeus) against challenge with a surrogate vaccinia virus by ALVAREZ-LAJONCHERE, Liz, AMADOR-CANIZARES, Yalena, COSME, Karelia, DUENAS-CARRERA, Santiago, FRIAS, Roberto, MILIAN, Yoamel, MUSACCHIO, Alexis, GUERRA, Ivis, ACOSTA-RIVERO, Nelson, MARTINEZ, Gillian, CASTRO, Jorge, PUENTES, Pedro

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