Search Results - "Coskren, Patrick J."
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The Electrotonic Structure of Pyramidal Neurons Contributing to Prefrontal Cortical Circuits in Macaque Monkeys Is Significantly Altered in Aging
Published in Cerebral cortex (New York, N.Y. 1991) (01-10-2009)“…Whereas neuronal numbers are largely preserved in normal aging, subtle morphological changes occur in dendrites and spines, whose electrotonic consequences…”
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Functional consequences of age-related morphologic changes to pyramidal neurons of the rhesus monkey prefrontal cortex
Published in Journal of computational neuroscience (01-04-2015)“…Layer 3 (L3) pyramidal neurons in the lateral prefrontal cortex (LPFC) of rhesus monkeys exhibit dendritic regression, spine loss and increased action…”
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Network effects of age-related NMDA reduction in a model of working memory
Published in BMC neuroscience (11-07-2008)Get full text
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Age-related neuromorphological distortion affects stability and robustness in a simulated test of spatial working memory
Published in BMC neuroscience (06-07-2007)Get full text
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Construction and analysis of morphologically detailed neuron models to study the physiological implications of age-related morphological changes in pyramidal cells in the dorsolateral prefrontal cortex of rhesus monkeys
Published 01-01-2011“…Aging in humans and non-primates is consistently associated with a certain degree of cognitive impairment, frequently involving spatial and temporal working…”
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Dissertation