Search Results - "Cosio, Manuel"

Immunologic Aspects of Chronic Obstructive Pulmonary Disease by Cosio, Manuel G, Saetta, Marina, Agusti, Alvar

“…This review is an account of how pulmonary damage caused by cigarette smoke and other environmental toxins can incite inflammatory and immunologic reactions…”
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Immune Inflammation and Disease Progression in Idiopathic Pulmonary Fibrosis by Balestro, Elisabetta, Calabrese, Fiorella, Turato, Graziella, Lunardi, Francesca, Bazzan, Erica, Marulli, Giuseppe, Biondini, Davide, Rossi, Emanuela, Sanduzzi, Alessandro, Rea, Federico, Rigobello, Chiara, Gregori, Dario, Baraldo, Simonetta, Spagnolo, Paolo, Cosio, Manuel G, Saetta, Marina

“…The clinical course in idiopathic pulmonary fibrosis (IPF) is highly heterogeneous, with some patients having a slow progression and others an accelerated…”
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Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today by Bazzan, Erica, Tinè, Mariaenrica, Casara, Alvise, Biondini, Davide, Semenzato, Umberto, Cocconcelli, Elisabetta, Balestro, Elisabetta, Damin, Marco, Radu, Claudia Maria, Turato, Graziella, Baraldo, Simonetta, Simioni, Paolo, Spagnolo, Paolo, Saetta, Marina, Cosio, Manuel G.

“…Extracellular vesicles (EVs) are a family of particles/vesicles present in blood and body fluids, composed of phospholipid bilayers that carry a variety of…”
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Blood Eosinophilia Neither Reflects Tissue Eosinophils nor Worsens Clinical Outcomes in Chronic Obstructive Pulmonary Disease by Turato, Graziella, Semenzato, Umberto, Bazzan, Erica, Biondini, Davide, Tinè, Mariaenrica, Torrecilla, Nerea, Forner, Marta, Marin, Josè M, Cosio, Manuel G, Saetta, Marina

“…To the Editor: The role of the blood eosinophil count as a biomarker predictor of the frequency of exacerbations and response to corticosteroid treatment in…”
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Giants in Chest Medicine: Professor James C. Hogg by Cosio, Manuel G.

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Animal models of chronic obstructive pulmonary disease by Wright, Joanne L, Cosio, Manuel, Churg, Andrew

“…The mechanisms involved in the genesis of chronic obstructive pulmonary disease (COPD) are poorly defined. This area is complicated and difficult to model…”
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Natural Killer Cell: Looks Like a Sniper but Is Part of the Team by Saetta, Marina, Turato, Graziella, Cosio, Manuel G

“…The major function of ILC1s, including NK cells, is to rapidly migrate to inflamed tissue and provide an early defense against infectious pathogens, recognize…”
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Mechanisms of cigarette smoke-induced COPD: insights from animal models by Churg, Andrew, Cosio, Manuel, Wright, Joanne L

“…Cigarette smoke-induced animal models of chronic obstructive pulmonary disease support the protease-antiprotease hypothesis of emphysema, although which cells…”
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Differences Between Early- and Late-Onset Asthma: Role of Comorbidities in Symptom Control by Turrin, Martina, Rizzo, Michele, Bonato, Matteo, Bazzan, Erica, Cosio, Manuel G., Semenzato, Umberto, Saetta, Marina, Baraldo, Simonetta

“…Asthma can present in early childhood or de novo in adulthood. Our understanding of the burden of comorbidities in adult asthmatic patients stratified by age…”
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Prognostic role of MUC5B rs35705950 genotype in patients with idiopathic pulmonary fibrosis (IPF) on antifibrotic treatment by Biondini, Davide, Cocconcelli, Elisabetta, Bernardinello, Nicol, Lorenzoni, Giulia, Rigobello, Chiara, Lococo, Sara, Castelli, Gioele, Baraldo, Simonetta, Cosio, Manuel G, Gregori, Dario, Saetta, Marina, Balestro, Elisabetta, Spagnolo, Paolo

“…A common variant located in the promoter region of MUC5B (rs35705950) is the strongest risk factor for sporadic and familiar IPF, as well as a predictor of…”
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Dual polarization of human alveolar macrophages progressively increases with smoking and COPD severity by Bazzan, Erica, Turato, Graziella, Tinè, Mariaenrica, Radu, Claudia M, Balestro, Elisabetta, Rigobello, Chiara, Biondini, Davide, Schiavon, Marco, Lunardi, Francesca, Baraldo, Simonetta, Rea, Federico, Simioni, Paolo, Calabrese, Fiorella, Saetta, Marina, Cosio, Manuel G

“…It is known that tissue macrophages derive not only from blood monocytes but also from yolk sac or fetal liver, and the tissue of residence guides their…”
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Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease: Incidence and Predicting Factors by DE TORRES, Juan P, MARIN, Jose M, COSIO, Manuel G, CELLI, Bartolome R, CASANOVA, Ciro, COTE, Claudia, CARRIZO, Santiago, CORDOBA-LANUS, Elizabeth, BAZ-DAVILA, Rebeca, ZULUETA, Javier J, AGUIRRE-JAIME, Armando, SAETTA, Marina

“…Little is known about the clinical factors associated with the development of lung cancer in patients with chronic obstructive pulmonary disease (COPD),…”
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The Emerging Role of Extracellular Vesicles Detected in Different Biological Fluids in COPD by Neri, Tommaso, Celi, Alessandro, Tinè, Mariaenrica, Bernardinello, Nicol, Cosio, Manuel G, Saetta, Marina, Nieri, Dario, Bazzan, Erica

“…The pathogenesis of chronic obstructive pulmonary disease (COPD) is characterized by complex cellular and molecular mechanisms, not fully elucidated so far. It…”
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Unveiling the Cutting-Edge Impact of Polarized Macrophage-Derived Extracellular Vesicles and MiRNA Signatures on TGF-β Regulation within Lung Fibroblasts by Casara, Alvise, Conti, Maria, Bernardinello, Nicol, Tinè, Mariaenrica, Baraldo, Simonetta, Turato, Graziella, Semenzato, Umberto, Celi, Alessandro, Spagnolo, Paolo, Saetta, Marina, Cosio, Manuel G, Neri, Tommaso, Biondini, Davide, Bazzan, Erica

“…Depending on local cues, macrophages can polarize into classically activated (M1) or alternatively activated (M2) phenotypes. This study investigates the…”
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Giants in Chest Medicine by Cosio, Manuel G., MD

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Microvesicles in bronchoalveolar lavage as a potential biomarker of COPD by Bazzan, Erica, Radu, Claudia Maria, Tinè, Mariaenrica, Neri, Tommaso, Biondini, Davide, Semenzato, Umberto, Casara, Alvise, Balestro, Elisabetta, Simioni, Paolo, Celi, Alessandro, Cosio, Manuel G, Saetta, Marina

“…Microvesicles (MVs) released from almost all cells are recognized as cell communication tools. MVs have been investigated in several inflammatory diseases but…”
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Immune activation in α1-antitrypsin-deficiency emphysema. Beyond the protease-antiprotease paradigm by Baraldo, Simonetta, Turato, Graziella, Lunardi, Francesca, Bazzan, Erica, Schiavon, Marco, Ferrarotti, Ilaria, Molena, Beatrice, Cazzuffi, Riccardo, Damin, Marco, Balestro, Elisabetta, Luisetti, Maurizio, Rea, Federico, Calabrese, Fiorella, Cosio, Manuel G, Saetta, Marina

“…α1-Antitrypsin (AAT) is a potent protease inhibitor, deficiency of which is associated with the presence of emphysema. An imbalance of elastase and…”
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Do Circulating Extracellular Vesicles Strictly Reflect Bronchoalveolar Lavage Extracellular Vesicles in COPD? by Tinè, Mariaenrica, Neri, Tommaso, Biondini, Davide, Bernardinello, Nicol, Casara, Alvise, Conti, Maria, Minniti, Marianna, Cosio, Manuel G, Saetta, Marina, Celi, Alessandro, Nieri, Dario, Bazzan, Erica

“…Cell-derived extracellular vesicles (EVs) found in the circulation and body fluids contain biomolecules that could be used as biomarkers for lung and other…”
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Alpha-1 Antitrypsin Deficiency: Beyond the Protease/Antiprotease Paradigm by Cosio, Manuel G, Bazzan, Erica, Rigobello, Chiara, Tinè, Mariaenrica, Turato, Graziella, Baraldo, Simonetta, Saetta, Marina

“…From the discovery that alpha-1 antitrypsin (AAT) was an effective inhibitor of neutrophil elastase originated the classic paradigm of protease/antiprotease…”
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Clinical and Pathologic Factors Predicting Future Asthma in Wheezing Children. A Longitudinal Study by Bonato, Matteo, Bazzan, Erica, Snijders, Deborah, Tinè, Mariaenrica, Biondini, Davide, Turato, Graziella, Balestro, Elisabetta, Papi, Alberto, Cosio, Manuel G, Barbato, Angelo, Baraldo, Simonetta, Saetta, Marina

“…Wheeze is a common symptom in infants, but not all wheezers develop asthma. Indeed, up to 50% of wheezing children outgrow their symptoms by school age. How to…”
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