Search Results - "Cosi, C"

Biomarkers and clinical predictors of long-term course in obsessivecompulsive disorder: A prospective cohort study by López-Rodriguez, S, P Alonso Ortega, Cosi, C Segalàs, E Real Barrero, Triquell, S Bertolín, C Soriano Mas, Á Carracedo Alvarez, Menchón Magriña, J M

“…IntroductionThe purpose of the research project is to analyze the long-term evolution of obsessive-compulsive disorder (OCD) from of a study of a cohort of…”
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Signal transduction and functional selectivity of F15599, a preferential post‐synaptic 5‐HT1A receptor agonist by Newman‐Tancredi, A, Martel, J‐C, Assié, M‐B, Buritova, J, Lauressergues, E, Cosi, C, Heusler, P, Bruins Slot, L, Colpaert, FC, Vacher, B, Cussac, D

“…Background and purpose:  Activation of post‐synaptic 5‐HT1A receptors may provide enhanced therapy against depression. We describe the signal transduction…”
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Signal transduction and functional selectivity of F15599, a preferential post‐synaptic 5‐HT 1A receptor agonist by Newman‐Tancredi, A, Martel, J‐C, Assié, M‐B, Buritova, J, Lauressergues, E, Cosi, C, Heusler, P, Bruins Slot, L, Colpaert, FC, Vacher, B, Cussac, D

“…Background and purpose:  Activation of post‐synaptic 5‐HT 1A receptors may provide enhanced therapy against depression. We describe the signal transduction…”
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F15063, a potential antipsychotic with D 2 /D 3 antagonist, 5‐HT 1A agonist and D 4 partial agonist properties: (I) in vitro receptor affinity and efficacy profile by Newman‐Tancredi, A, Assié, M‐B, Martel, J‐C, Cosi, C, Slot, L Bruins, Palmier, C, Rauly‐Lestienne, I, Colpaert, F, Vacher, B, Cussac, D

“…Background and purpose: Combining 5‐HT 1A receptor activation with dopamine D 2 /D 3 receptor blockade should improve negative symptoms and cognitive deficits…”
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Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia by Colpaert, F C, Tarayre, J P, Koek, W, Pauwels, P J, Bardin, L, Xu, X-J, Wiesenfeld-Hallin, Z, Cosi, C, Carilla-Durand, E, Assié, M B, Vacher, B

“…We report the discovery of F 13640 and evidence suggesting this agent to produce powerful, broad-spectrum analgesia by novel molecular and neuroadaptative…”
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Poly(ADP-ribose) polymerase: early involvement in glutamate-induced neurotoxicity in cultured cerebellar granule cells by Cosi, C, Suzuki, H, Milani, D, Facci, L, Menegazzi, M, Vantini, G, Kanai, Y, Skaper, S D

“…Glutamate neurotoxicity is correlated with an increase of cytosolic free Ca2+. In some cell systems, activation of Ca2+ dependent endonucleases or formation of…”
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P.2.d.013 F15599, a post-synaptic cortical preferential 5-HT1A agonist: I) functionally-selective signal transduction profile by Newman-Tancredi, A, Martel, J.C, Buritova, J, Lauressergues, E, Assie, M.B, Slot, L. Bruins, Cosi, C, Heusler, P, Cussac, D

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c-fos mRNA is spontaneously induced in the rat brain during the activity period of the circadian cycle by Grassi-Zucconi, G, Menegazzi, M, De Prati, A C, Bassetti, A, Montagnese, P, Mandile, P, Cosi, C, Bentivoglio, M

“…The basal expression of the proto-oncogene c-fos was studied by Northern blot analysis in different regions of the rat brain during 24 h. A striking…”
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Effects of kainic acid lesioning on poly(ADP-ribose) polymerase (PARP) activity in the rat striatum in vivo by Cosi, C, Cavalieri, E, Carcereri de Prati, A, Marien, M, Suzuki, H

“…Poly(ADP-ribose) polymerase (PARP) is activated in glutamate-induced toxicity of neurons in culture (Cosi et al., 1994). Since injection of the excitatory…”
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Poly(ADP-ribose) polymerase (PARP) revisited. A new role for an old enzyme: PARP involvement in neurodegeneration and PARP inhibitors as possible neuroprotective agents by Cosi, C, Suzuki, H, Skaper, S D, Milani, D, Facci, L, Menegazzi, M, Vantini, G, Kanai, Y, Degryse, A, Colpaert, F, Koek, W, Marien, M R

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Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57Bl/6 mice by Cosi, C

“…Treatment of C57Bl/6 mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduced striatal dopamine and cortical noradrenaline levels by 77-83% and…”
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F17464 a new antipsychotic with preferential D3 antagonist, 5-HT1A partial agonist properties. Neurochemical studies by Cosi, C., N’Guyen, V., Consul-Denjean, N., Auclair, A., Heusler, P., Martel, J.C., Leriche, L., Sokoloff, P., Gatti-McArthur, S.

“…F17464 is a new dopamine receptor antagonist that recently demonstrated antipsychotic activity in a proof of concept study in schizophrenic patients under…”
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Molecular cloning of the gene encoding the bovine brain ribonucelase and its expression in different regions of the brain by Sasso, M.P., Carsana, A., Confalone, E., Cosi, C., Sorrentino, S., Viola, M., Palmier, M., Russo, E., Furia, A.

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Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57B1/6 mice by Cosi, Cristina, Colpaert, Francis, Koek, Wouter, Degryse, Anne, Marien, Marc

“…Treatment of C57B1/6 mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduced striatal dopamine and cortical noradrenaline levels by 77–83% and…”
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Partial agonist properties of the antipsychotics SSR181507, aripiprazole and bifeprunox at dopamine D2 receptors: G protein activation and prolactin release by Cosi, Cristina, Carilla-Durand, Elisabeth, Assié, Marie Bernadette, Ormiere, Anne Marie, Maraval, Mireille, Leduc, Nathalie, Newman-Tancredi, Adrian

“…Dopamine D2 receptor antagonists induce hyperprolactinemia depending on the extent of D2 receptor blockade. We compared the effects of the new antipsychotic…”
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Novel antipsychotics activate recombinant human and native rat serotonin 5-HT1A receptors: affinity, efficacy and potential implications for treatment of schizophrenia by Newman-Tancredi, Adrian, Assié, Marie-Bernadette, Leduc, Nathalie, Ormière, Anne-Marie, Danty, Nathalie, Cosi, Cristina

“…Serotonin 5-HT1A receptors are promising targets in the management of schizophrenia but little information exists about affinity and efficacy of novel…”
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Role of donor/recipient Na +/H + antiport activity as a nonimmunologic predictor of kidney graft outcome by Matteucci, E., Carmeilini, M., Bertoni, C., Boldrini, E., Cosi, C., Mosca, F., Giampietro, O.

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Clozapine, ziprasidone and aripiprazole but not haloperidol protect against kainic acid-induced lesion of the striatum in mice, in vivo : Role of 5-HT1A receptor activation by COSI, Cristina, WAGET, Aurelie, ROLLET, Karin, TESORI, Valentina, NEWMAN-TANCREDI, Adrian

“…Excessive activation of non-NMDA receptors, AMPA and kainate, contributes to neuronal degeneration in acute and progressive pathologies, possibly including…”
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Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia by COLPAERT, F. C, TARAYRE, J. P, VACHER, B, KOEK, W, PAUWELS, P. J, BARDIN, L, XU, X.-J, WIESENFELD-HALLIN, Z, COSI, C, CARILLA-DURAND, E, ASSIE, M. B

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Agonist, antagonist, and inverse agonist properties of antipsychotics at human recombinant 5-HT(1A) receptors expressed in HeLa cells by Cosi, C, Koek, W

“…Agonist and antagonist properties of antipsychotics at human (h) recombinant 5-hydroxytryptamine (h5-HT(1A)) receptor have been examined previously in…”
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