Characteristics and outcomes of preterm neonates according to number of doses of surfactant received

Characteristics and outcomes of preterm neonates according to number of doses of surfactant received

Objectives To identify characteristics and outcomes of infants who received multiple doses of surfactant vs those who received one dose or none. Study design In this retrospective study, we included neonates of 22–28 weeks’ gestation admitted to NICUs in the Canadian Neonatal Network. Patients were...

Full description

Saved in:
Bibliographic Details
Published in:Journal of perinatology Vol. 41; no. 1; pp. 39 - 46
Main Authors: Coshal, Hanita, Mukerji, Amit, Lemyre, Brigitte, Ng, Eugene H., Alvaro, Ruben, Ethier, Guillaume, Yoon, Eugene W., Beltempo, Marc, Shah, Prakesh S.
Format: Journal Article
Language:English
Published: New York Nature Publishing Group US 01-01-2021
Nature Publishing Group
Subjects:
692/308/174
692/308/409
692/499
692/700/1720
Canada - epidemiology
Drug therapy
Dysplasia
Gestation
Humans
Infant, Extremely Premature
Infant, Newborn
Infants
Infants (Premature)
Medicine
Medicine & Public Health
Mortality
Neonates
Newborn babies
Patient outcomes
Pediatric research
Pediatric respiratory diseases
Pediatric Surgery
Pediatrics
Premature birth
Pulmonary surfactant
Pulmonary Surfactants
Retinopathy
Retrospective Studies
Surface-Active Agents
Surfactants
Canada
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives To identify characteristics and outcomes of infants who received multiple doses of surfactant vs those who received one dose or none. Study design In this retrospective study, we included neonates of 22–28 weeks’ gestation admitted to NICUs in the Canadian Neonatal Network. Patients were divided into three groups: no surfactant, single dose, and multiple doses. The primary outcome was a composite of mortality or any of the major morbidities, including severe neurological injury, bronchopulmonary dysplasia, or ≥stage 3 retinopathy of prematurity. Results Of 8024 eligible neonates, 2461 (31%) did not receive surfactant, 3545 (44%) received one dose, and 2018 (25%) received >1 dose. Receiving one or more doses of surfactant was associated with significantly higher adjusted odds of mortality or major morbidities in a dose-dependent manner. Conclusions Receiving one or more doses of surfactant was associated with adverse neonatal outcomes. Receipt of more than one dose may reflect underlying severe lung immaturity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-020-00779-9