Search Results - "Cosgrave, A Siobhan"

Optimizing regulatable gene expression using adenoviral vectors by Lee, Youn‐Bok, Glover, Colin P. J., Cosgrave, A. Siobhan, Bienemann, Alison, Uney, James B.

“…Inducible gene expression systems have typically encountered limitations, such as pleitropic effects of the inducer, basal leakiness, toxicity of inducing…”
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The effects of nitric oxide inhibition prior to kainic acid treatment on neuro- and gliogenesis in the rat dentate gyrus in vivo and in vitro by Cosgrave, A Siobhan, McKay, Jennifer S, Morris, Richard, Quinn, John P, Thippeswamy, Thimmasettappa

“…Treatment with the nitric oxide synthase (NOS) inhibitor, L-NAME prior to the induction of seizures with kainic acid (KA) [L-NAME+KA] increases the expression…”
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Adenoviral-Mediated, High-Level, Cell-Specific Transgene Expression: A SYN1-WPRE Cassette Mediates Increased Transgene Expression with No Loss of Neuron Specificity by Glover, Colin P.J., Bienemann, Alison S., Heywood, Darren J., Cosgrave, A.Siobhan, Uney, James B.

“…Viral vectors are excellent tools for studying gene function in the brain, although a limitation has been the ability to effectively target transgene…”
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Increased utility in the CNS of a powerful neuron-specific tetracycline-regulatable adenoviral system developed using a post-transcriptional enhancer by Lee, Youn-Bok, Cosgrave, A. Siobhan, Glover, Colin P. J., Bienemann, Alison, Heywood, Darren, Hobson, Russell J., Uney, James B.

“…Background In previous studies we have found that the tetracycline (Tet)‐regulatable system functions best in recombinant adenoviral (Ad) vectors when the Tet…”
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