Search Results - "Cosand, Wesley L."

Generation of 5-fluorouracil from 5-fluorocytosine by monoclonal antibody-cytosine deaminase conjugates by Senter, Peter D, Su, Peter C. D, Katsuragi, Tohoru, Sakai, Takuo, Cosand, Wesley L, Hellstrom, Ingegerd, Hellstrom, Karl Erik

“…Cytosine deaminase (CDase) catalyzes the conversion of cytosine to uracil and is also able to convert the clinically used antifungal agent 5-fluorocytosine…”
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Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine by WALLACE, P. M, MACMASTER, J. F, SMITH, V. F, KERR, D. E, SENTER, P. D, COSAND, W. L

“…Cytosine deaminase (CD) is a microbial enzyme that can convert the antifungal agent 5-fluorocytosine (5-FC) into the antitumor agent, 5-fluorouracil (5-FU)…”
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Monoclonal antibody homodimers : enhanced antitumor activity in nude mice by WOLFF, E. A, SCHREIBER, G. J, COSAND, W. L, RAFF, H. V

“…The potential for enhancing antibody potency by increasing avidity was investigated using monoclonal IgG homodimers. Chemically linked dimers were made from a…”
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Proteomics in the post-genome age by Dongre, Ashok R., Opiteck, Gregory, Cosand, Wesley L., Hefta, Stanley A.

“…The genome sequencing effort has helped spawn the burgeoning field of proteomics. This review article examines state‐of‐the‐art proteomics methods that are…”
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Lysis of ras oncogene-transformed cells by specific cytotoxic T lymphocytes elicited by primary in vitro immunization with mutated ras peptide by PEACE, D. J, SMITH, J. W, WEI CHEN, SHENG-GUO YOU, COSAND, W. L, BLAKE, J, CHEEVER, M. A

“…Ras protooncogenes are activated by characteristic point mutations in a wide variety of malignancies. The expressed p21ras proteins are oncogenic by virtue of…”
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In vitro and in vivo activities of a doxorubicin prodrug in combination with monoclonal antibody beta-lactamase conjugates by Svensson, H P, Vrudhula, V M, Emswiler, J E, MacMaster, J F, Cosand, W L, Senter, P D, Wallace, P M

“…A cephalosporin derivative of doxorubicin (C-Dox) was evaluated as a prodrug for activation by mAb conjugates of the beta-lactamase from Enterobacter cloacae…”
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Peptides related to the carboxyl terminus of human platelet factor IV with antibacterial activity by DARVEAU, R. P, BLAKE, J, SEACHORD, C. L, COSAND, W. L, CUNNINGHAM, M. D, CASSIANO-CLOUGH, L, MALONEY, G

“…A peptide (C13) corresponding to the last 13 amino acids of the carboxyl terminus of human platelet factor IV was found to be antibacterial. Amino acid…”
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Enhanced transmembrane signalling activity of monoclonal antibody heteroconjugates suggests molecular interactions between receptors on the T cell surface by Ledbetter, J A, Norris, N A, Grossmann, A, Grosmaire, L S, June, C H, Uckun, F M, Cosand, W L, Rabinovitch, P S

“…Signal transduction occurs through multiple receptors expressed on mature, resting T cells. In addition to the CD3-T cell receptor complex, the CD2, CD4, CD5,…”
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Bispecific receptor globulins, novel tools for the study of cellular interactions. Preparation and characterization of an E-selectin/P-selectin bispecific receptor globulin by Dietsch, M T, Smith, V F, Cosand, W L, Damle, N K, Ledbetter, J A, Linsley, P S, Aruffo, A

“…In recent years the functional consequences of receptor/ligand interactions have been studied in vitro and in vivo using monospecific recombinant…”
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Structure-activity analysis of the antitumor and hemolytic properties of the amphiphilic alpha-helical peptide, C18G by Peck-Miller, K A, Blake, J, Cosand, W L, Darveau, R P, Fell, H P

“…The in vitro antitumor and hemolytic activities of analogs of peptide C18G were compared in order to elucidate important structural features which affect…”
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Ethylcarbamoyl protection for cysteine in the preparation of peptide-conjugate immunogens by Blake, J, Woodworth, B A, Litzi-Davis, L, Cosand, W L

“…During the solid-phase synthesis of over 100 peptides, we have observed that the ethylcarbamoyl group is useful for the side chain protection of cysteine in…”
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Concept of Internal Structural Controls for Evaluation of Inactive Synthetic Peptide Analogs: Synthesis of [Orn13,14]apamin and Its Guanidination to an Apamin Derivative with Full Neurotoxic Activity by Cosand, Wesley L., Merrifield, R. B.

“…The importance of arginine residues 13 and 14 in the bee venom neurotoxin, apamin, was tested by the synthesis of replacement analogs…”
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