Search Results - "Coquerel, David"

Hypertonic sodium lactate improves microcirculation, cardiac function, and inflammation in a rat model of sepsis by Besnier, Emmanuel, Coquerel, David, Kouadri, Geoffrey, Clavier, Thomas, Favory, Raphael, Duburcq, Thibault, Lesur, Olivier, Bekri, Soumeya, Richard, Vincent, Mulder, Paul, Tamion, Fabienne

“…Hypertonic sodium lactate (HSL) may be of interest during inflammation. We aimed to evaluate its effects during experimental sepsis in rats (cecal ligation and…”
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The apelinergic system as an alternative to catecholamines in low-output septic shock by Coquerel, David, Sainsily, Xavier, Dumont, Lauralyne, Sarret, Philippe, Marsault, Éric, Auger-Messier, Mannix, Lesur, Olivier

“…Catecholamines, in concert with fluid resuscitation, have long been recommended in the management of septic shock. However, not all patients respond positively…”
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Enhanced angiogenesis and increased cardiac perfusion after myocardial infarction in protein tyrosine phosphatase 1B‐deficient mice by Besnier, Marie, Galaup, Ariane, Nicol, Lionel, Henry, Jean‐Paul, Coquerel, David, Gueret, Alexandre, Mulder, Paul, Brakenhielm, Ebba, Thuillez, Christian, Germain, Stéphane, Richard, Vincent, Ouvrard‐Pascaud, Antoine

“…The protein tyrosine phosphatase 1B (PTP1B) modulates tyrosine kinase receptors, among which is the vascular endothelial growth factor receptor type 2…”
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Apelin-13 in septic shock: effective in supporting hemodynamics in sheep but compromised by enzymatic breakdown in patients by Coquerel, David, Lamoureux, Julie, Chagnon, Frédéric, Trân, Kien, Sage, Michael, Fortin-Pellerin, Etienne, Delile, Eugénie, Sainsily, Xavier, Fournier, Justin, Dumont, Audrey-Ann, Auger-Messier, Mannix, Sarret, Philippe, Marsault, Eric, Praud, Jean-Paul, Fülöp, Tamàs, Lesur, Olivier

“…Sepsis is a prevalent life-threatening condition related to a systemic infection, and with unresolved issues including refractory septic shock and organ…”
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Elabela Protects Spontaneously Hypertensive Rats From Hypertension and Cardiorenal Dysfunctions Exacerbated by Dietary High-Salt Intake by Sainsily, Xavier, Coquerel, David, Giguère, Hugo, Dumont, Lauralyne, Tran, Kien, Noll, Christophe, Ionescu, Andrei L., Côté, Jérôme, Longpré, Jean-Michel, Carpentier, André, Marsault, Éric, Lesur, Olivier, Sarret, Philippe, Auger-Messier, Mannix

“…Objectives: Arterial hypertension, when exacerbated by excessive dietary salt intake, worsens the morbidity and mortality rates associated with cardiovascular…”
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Preservation of epoxyeicosatrienoic acid bioavailability prevents renal allograft dysfunction and cardiovascular alterations in kidney transplant recipients by Duflot, Thomas, Laurent, Charlotte, Soudey, Anne, Fonrose, Xavier, Hamzaoui, Mouad, Iacob, Michèle, Bertrand, Dominique, Favre, Julie, Etienne, Isabelle, Roche, Clothilde, Coquerel, David, Le Besnerais, Maëlle, Louhichi, Safa, Tarlet, Tracy, Li, Dongyang, Brunel, Valéry, Morisseau, Christophe, Richard, Vincent, Joannidès, Robinson, Stanke-Labesque, Françoise, Lamoureux, Fabien, Guerrot, Dominique, Bellien, Jérémy

“…This study addressed the hypothesis that epoxyeicosatrienoic acids (EETs) synthesized by CYP450 and catabolized by soluble epoxide hydrolase (sEH) are involved…”
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Reduced Insulin Resistance Contributes to the Beneficial Effect of Protein Tyrosine Phosphatase-1B Deletion in a Mouse Model of Sepsis by Delile, Eugénie, Nevière, Rémi, Thiébaut, Pierre-Alain, Maupoint, Julie, Mulder, Paul, Coquerel, David, Renet, Sylvanie, Rieusset, Jennifer, Richard, Vincent, Tamion, Fabienne

“…ABSTRACTHyperglycemia is a common feature of septic patients and has been associated with poor outcome and high mortality. In contrast, insulin has been shown…”
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Soluble Epoxide Hydrolase Inhibition Prevents Experimental Type 4 Cardiorenal Syndrome by Hamzaoui, Mouad, Roche, Clothilde, Coquerel, David, Duflot, Thomas, Brunel, Valery, Mulder, Paul, Richard, Vincent, Bellien, Jérémy, Guerrot, Dominique

“…Cardiovascular diseases (CVD) remain the leading cause of morbimortality in patients with chronic kidney disease (CKD). The aim of this study was to assess the…”
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Apelin Compared With Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial Dysfunction by Chagnon, Frederic, Coquerel, David, Salvail, Dany, Marsault, Eric, Dumaine, Robert, Auger-Messier, Mannix, Sarret, Philippe, Lesur, Olivier

“…OBJECTIVE:Dobutamine is the currently recommended β-adrenergic inotropic drug for supporting sepsis-induced myocardial dysfunction when cardiac output index…”
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Identification of nascent cardiovascular proteomes by cell-type-specific metabolic labeling in experimental sepsis mouse model by Dumont, Audrey-Ann, Kpegba, Dhyana, Dumont, Lauralyne, Bentzinger, C. Florian, Blondin, Denis, Lesur, Olivier, Coquerel, David, Auger-Messier, Mannix

“…Abstract only BACKGROUND – Sepsis is characterized by an overwhelming systemic inflammatory response to infection that may lead to multiple organ failure and…”
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ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic Shock by Coquerel, David, Chagnon, Frédéric, Sainsily, Xavier, Dumont, Lauralyne, Murza, Alexandre, Côté, Jérôme, Dumaine, Robert, Sarret, Philippe, Marsault, Éric, Salvail, Dany, Auger-Messier, Mannix, Lesur, Olivier

“…OBJECTIVES:Apelin-13 was recently proposed as an alternative to the recommended β-adrenergic drugs for supporting endotoxin-induced myocardial dysfunction…”
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Discovery and Structure–Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions by Murza, Alexandre, Sainsily, Xavier, Coquerel, David, Côté, Jérôme, Marx, Patricia, Besserer-Offroy, Élie, Longpré, Jean-Michel, Lainé, Jean, Reversade, Bruno, Salvail, Dany, Leduc, Richard, Dumaine, Robert, Lesur, Olivier, Auger-Messier, Mannix, Sarret, Philippe, Marsault, Éric

“…ELABELA (ELA) was recently discovered as a novel endogenous ligand of the apelin receptor (APJ), a G protein-coupled receptor. ELA signaling was demonstrated…”
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Gαi-biased apelin analog protects against isoproterenol-induced myocardial dysfunction in rats by Coquerel, David, Delile, Eugénie, Dumont, Lauralyne, Chagnon, Frédéric, Murza, Alexandre, Sainsily, Xavier, Salvail, Dany, Sarret, Philippe, Marsault, Eric, Auger-Messier, Mannix, Lesur, Olivier

“…Apelin receptor (APJ) activation by apelin-13 (APLN-13) engages both Gαi proteins and β-arrestins, stimulating distinct intracellular pathways and triggering…”
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Hemodynamic impacts of apelin-13 in a neonatal lamb model of septic peritonitis by Simard, Émile, Morin, Christophe, Coquerel, David, Chagnon, Frédéric, Nadeau, Charlène, Samson, Nathalie, Praud, Jean-Paul, Lesur, Olivier, Fortin-Pellerin, Étienne

“…Background Apelins are potential candidate therapeutic molecules for hemodynamic support. The objective of this study was to assess the hemodynamic impacts of…”
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Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor by Trân, Kien, Murza, Alexandre, Sainsily, Xavier, Delile, Eugénie, Couvineau, Pierre, Côté, Jérôme, Coquerel, David, Peloquin, Maude, Auger-Messier, Mannix, Bouvier, Michel, Lesur, Olivier, Sarret, Philippe, Marsault, Éric

“…ELABELA (ELA) is the second endogenous ligand of the apelin receptor (APJ). Although apelin-13 and ELA both target APJ, there is limited information on…”
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Protein tyrosine phosphatase 1B inactivation limits aging-associated heart failure in mice by Besnier, Marie, Coquerel, David, Favre, Julie, Dumesnil, Anais, Guerrot, Domique, Remy-Jouet, Isabelle, Mulder, Paul, Djerada, Zoubir, Tamion, Fabienne, Richard, Vincent, Ouvrard-Pascaud, Antoine

“…We have previously shown that protein tyrosine phosphatase 1B (PTP1B) inactivation in mice [PTP1B-deficient (PTP1B ) mice] improves left ventricular (LV)…”
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Soluble epoxide hydrolase inhibition improves coronary endothelial function and prevents the development of cardiac alterations in obese insulin-resistant mice by Roche, Clothilde, Besnier, Marie, Cassel, Roméo, Harouki, Najah, Coquerel, David, Guerrot, Dominique, Nicol, Lionel, Loizon, Emmanuelle, Remy-Jouet, Isabelle, Morisseau, Christophe, Mulder, Paul, Ouvrard-Pascaud, Antoine, Madec, Anne-Marie, Richard, Vincent, Bellien, Jeremy

“…This study addressed the hypothesis that inhibiting the soluble epoxide hydrolase (sEH)-mediated degradation of epoxy-fatty acids, notably epoxyeicosatrienoic…”
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Protein tyrosine phosphatase 1B regulates endothelial endoplasmic reticulum stress; role in endothelial dysfunction by Thiebaut, Pierre-Alain, Delile, Eugénie, Coquerel, David, Brunel, Jean-Michel, Renet, Sylvanie, Tamion, Fabienne, Richard, Vincent

“…Protein tyrosine phosphatase 1B (PTP1B) impairs nitric oxide (NO) production and induces endothelial dysfunction in various diseases, including diabetes,…”
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Size-Reduced Macrocyclic Analogues of [Pyr1]‑apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects by Tran, Kien, Sainsily, Xavier, Côté, Jérôme, Coquerel, David, Couvineau, Pierre, Saibi, Sabrina, Haroune, Lounès, Besserer-Offroy, Élie, Flynn-Robitaille, Joël, Resua Rojas, Martin, Murza, Alexandre, Longpré, Jean-Michel, Auger-Messier, Mannix, Lesur, Olivier, Bouvier, Michel, Marsault, Éric, Boudreault, Pierre-Luc, Sarret, Philippe

“…We previously reported a series of macrocyclic analogues of [Pyr1]-apelin-13 (Ape13) with increased plasma stability and potent APJ agonist properties. Based…”
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A Systematic Exploration of Macrocyclization in Apelin-13: Impact on Binding, Signaling, Stability, and Cardiovascular Effects by Trân, Kien, Murza, Alexandre, Sainsily, Xavier, Coquerel, David, Côté, Jérôme, Belleville, Karine, Haroune, Lounès, Longpré, Jean-Michel, Dumaine, Robert, Salvail, Dany, Lesur, Olivier, Auger-Messier, Mannix, Sarret, Philippe, Marsault, Éric

“…The apelin receptor generates increasing interest as a potential target across several cardiovascular indications. However, the short half-life of its cognate…”
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