Search Results - "Coqueran, Berard"
-
1
Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke
Published in European heart journal (01-12-2013)“…Given the impact of vascular injuries and oedema on brain damage caused during stroke, vascular protection represents a major medical need. We hypothesized…”
Get full text
Journal Article -
2
Neuroinflammation, myelin and behavior: Temporal patterns following mild traumatic brain injury in mice
Published in PloS one (14-09-2017)“…Traumatic brain injury (TBI) results in white matter injury (WMI) that is associated with neurological deficits. Neuroinflammation originating from microglial…”
Get full text
Journal Article -
3
Improved Reperfusion and Vasculoprotection by the Poly(ADP-Ribose)Polymerase Inhibitor PJ34 After Stroke and Thrombolysis in Mice
Published in Molecular neurobiology (01-12-2018)“…Benefits from thrombolysis with recombinant tissue plasminogen activator (rt-PA) after ischemic stroke remain limited due to a narrow therapeutic window, low…”
Get full text
Journal Article -
4
Impaired platelet activation and cAMP homeostasis in MRP4-deficient mice
Published in Blood (08-10-2015)“…Molecules that reduce the level of cyclic adenosine 5′-monophosphate (cAMP) in the platelet cytosol, such as adenosine 5′-diphosphate (ADP) secreted from dense…”
Get full text
Journal Article -
5
Progesterone Receptors: A Key for Neuroprotection in Experimental Stroke
Published in Endocrinology (Philadelphia) (01-08-2012)“…Progesterone receptors (PR) are expressed throughout the brain. However, their functional significance remains understudied. Here we report a novel role of PR…”
Get full text
Journal Article -
6
Experimental modeling of recombinant tissue plasminogen activator effects after ischemic stroke
Published in Experimental neurology (01-12-2012)“…Recombinant tissue plasminogen activator (rt-PA) is currently the only approved drug for ischemic stroke treatment, with a dose of 0.9mg/kg. Since the…”
Get full text
Journal Article -
7
Reduction of hemorrhagic transformation by PJ34, a poly(ADP-ribose)polymerase inhibitor, after permanent focal cerebral ischemia in mice
Published in European journal of pharmacology (24-06-2008)“…Hemorrhagic transformation is an aggravating event that occurs in 15 to 43% of patients suffering from ischemic stroke. This phenomenon due to blood-brain…”
Get full text
Journal Article -
8
Prevention of rt-PA induced blood–brain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice
Published in Experimental neurology (01-10-2013)“…Recombinant tissue plasminogen activator (rt-PA) is the only pharmacological treatment approved for thrombolysis in patients suffering from ischemic stroke,…”
Get full text
Journal Article -
9
Combined therapy with PJ34, a poly(ADP-ribose)polymerase inhibitor, reduces tissue plasminogen activator-induced hemorrhagic transformations in cerebral ischemia in mice
Published in Fundamental & clinical pharmacology (01-08-2013)“…Recombinant tissue‐type plasminogen activator (rt‐PA) is presently the only pharmacological treatment approved for thrombolysis in patients suffering from…”
Get full text
Journal Article -
10
Long-term histological and behavioural characterisation of a collagenase-induced model of intracerebral haemorrhage in rats
Published in Journal of neuroscience methods (30-08-2010)“…Although intracerebral haemorrhage (ICH) entails the highest rates of mortality and disability of all stroke subtypes, efficient neuroprotective therapy is…”
Get full text
Journal Article -
11
Lactococcus lactis SpOx Spontaneous Mutants: a Family of Oxidative-Stress-Resistant Dairy Strains
Published in Applied and Environmental Microbiology (01-05-2005)“…Numerous industrial bacteria generate hydrogen peroxide (H₂O₂), which may inhibit the growth of other bacteria in mixed ecosystems. We isolated spontaneous…”
Get full text
Journal Article -
12
Prevention of rt-PA induced bloodabrain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice
Published in Experimental neurology (01-10-2013)“…Recombinant tissue plasminogen activator (rt-PA) is the only pharmacological treatment approved for thrombolysis in patients suffering from ischemic stroke,…”
Get full text
Journal Article -
13