Search Results - "Coppola, Thierry"

Sortilin in Glucose Homeostasis: From Accessory Protein to Key Player? by Blondeau, Nicolas, Béraud-Dufour, Sophie, Lebrun, Patricia, Hivelin, Céline, Coppola, Thierry

“…The pharmacological properties and physiological roles of the type I receptor sortilin, also called neurotensin receptor-3, are various and complex. Sortilin…”
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Molecular Organization and Regulation of the Mammalian Synapse by the Post-Translational Modification SUMOylation by Chato-Astrain, Isabel, Pronot, Marie, Coppola, Thierry, Martin, Stéphane

“…Neurotransmission occurs within highly specialized compartments forming the active synapse where the complex organization and dynamics of the interactions are…”
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Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design by Mazella, Jean, Pétrault, Olivier, Lucas, Guillaume, Deval, Emmanuel, Béraud-Dufour, Sophie, Gandin, Carine, El-Yacoubi, Malika, Widmann, Catherine, Guyon, Alice, Chevet, Eric, Taouji, Said, Conductier, Grégory, Corinus, Alain, Coppola, Thierry, Gobbi, Gabriella, Nahon, Jean-Louis, Heurteaux, Catherine, Borsotto, Marc

“…Current antidepressant treatments are inadequate for many individuals, and when they are effective, they require several weeks of administration before a…”
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Focal Adhesion Kinase-Dependent Role of the Soluble Form of Neurotensin Receptor-3/Sortilin in Colorectal Cancer Cell Dissociation by Béraud-Dufour, Sophie, Devader, Chistelle, Massa, Fabienne, Roulot, Morgane, Coppola, Thierry, Mazella, Jean

“…The aim of the present review is to unravel the mechanisms of action of the soluble form of the neurotensin (NT) receptor-3 (NTSR3), also called Sortilin, in…”
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Unlocking Therapeutic Synergy: Tailoring Drugs for Comorbidities such as Depression and Diabetes through Identical Molecular Targets in Different Cell Types by Coppola, Thierry, Daziano, Guillaume, Legroux, Ilona, Béraud-Dufour, Sophie, Blondeau, Nicolas, Lebrun, Patricia

“…Research in the field of pharmacology aims to generate new treatments for pathologies. Nowadays, there are an increased number of chronic disorders that…”
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A role for glutamate transporters in the regulation of insulin secretion by Gammelsaeter, Runhild, Coppola, Thierry, Marcaggi, Païkan, Storm-Mathisen, Jon, Chaudhry, Farrukh A, Attwell, David, Regazzi, Romano, Gundersen, Vidar

“…In the brain, glutamate is an extracellular transmitter that mediates cell-to-cell communication. Prior to synaptic release it is pumped into vesicles by…”
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Neurotensin-induced Erk1/2 phosphorylation and growth of human colonic cancer cells are independent from growth factors receptors activation by Massa, Fabienne, Tormo, Aurélie, Béraud-Dufour, Sophie, Coppola, Thierry, Mazella, Jean

“…► We compare intracellular pathways of NT and EGF in HT29 cells. ► NT does not transactivate EGFR. ► Transactivation of EGFR is not a general rule in cancer…”
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Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis by Waselle, Laurent, Coppola, Thierry, Fukuda, Mitsunori, Iezzi, Mariella, El-Amraoui, Aziz, Petit, Christine, Regazzi, Romano

“…Rab27a is a GTPase associated with insulin-containing secretory granules of pancreatic beta-cells. Selective reduction of Rab27a expression by RNA interference…”
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ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis by Abderrahmani, Amar, Cheviet, Séverine, Ferdaoussi, Mourad, Coppola, Thierry, Waeber, Gérard, Regazzi, Romano

“…The GTPases Rab3a and Rab27a and their effectors Granuphilin/Slp4 and Noc2 are essential regulators of neuroendocrine secretion. Chronic exposure of pancreatic…”
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Neurotensin and its receptors in the control of glucose homeostasis by Mazella, Jean, Béraud-Dufour, Sophie, Devader, Christelle, Massa, Fabienne, Coppola, Thierry

“…The pharmacological roles of the neuropeptide neurotensin through its three known receptors are various and complex. Neurotensin is involved in several…”
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Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin by Mazella, J., Coppola, Thierry, Borsotto, Marc, Djillani, Alaeddine, Moha ou Maati, Hamid, Moreno, Sébastien, Abderrahmani, Amar, Devader, Christelle, Béraud-Dufour, Sophie, Hivelin, Céline, Heurteaux, Catherine

“…Inhibition of the potassium channels TREK-1 by spadin (SPA) is currently thought to be a promising therapeutic target for the treatment of depression. Since…”
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Direct Interaction of the Rab3 Effector RIM with Ca2+Channels, SNAP-25, and Synaptotagmin by Coppola, Thierry, Magnin-Lüthi, Sarah, Perret-Menoud, Véronique, Gattesco, Sonia, Schiavo, Giampietro, Regazzi, Romano

“…To define the role of the Rab3-interacting molecule RIM in exocytosis we searched for additional binding partners of the protein. We found that the two C2…”
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The anti-apoptotic role of neurotensin by Devader, Christelle, Béraud-Dufour, Sophie, Coppola, Thierry, Mazella, Jean

“…The neuropeptide, neurotensin, exerts numerous biological functions, including an efficient anti-apoptotic role, both in the central nervous system and in the…”
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Structure, Functional Expression, and Cerebral Localization of the Levocabastine-Sensitive Neurotensin/Neuromedin N Receptor from Mouse Brain by Mazella, Jean, Botto, Jean-Marie, Guillemare, Eric, Coppola, Thierry, Sarret, Philippe, Vincent, Jean-Pierre

“…This work describes the cloning and expression of the levocabastine-sensitive neurotensin (NT) receptor from mouse brain. The receptor protein comprises 417…”
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Cloning provides evidence for a family of inward rectifier and G-protein coupled K + channels in the brain by Lesage, Florian, Duprat, Fabrice, Fink, Michel, Guillemare, Eric, Coppola, Thierry, Lazdunski, Michel, Hugnot, Jean-Philippe

“…MbIRK3, mbGIRK2 and mbGIRK3 K + channels cDNAs have been cloned from adult mouse brain. These eDNAs encode polypeptides of 445, 414 and 376 amino acids,…”
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Sortilin derived propeptide regulation during adipocyte differentiation and inflammation by Hivelin, Céline, Mazella, Jean, Coppola, Thierry

“…In this work, we aimed to correlate the expression of sortilin with the production of sortilin-derived propeptide (PE) during adipocyte differentiation,…”
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Spadin, a Sortilin-Derived Peptide, Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design by Mazella, Jean, Pétrault, Olivier, Lucas, Guillaume, Deval, Emmanuel, Béraud-Dufour, Sophie, Gandin, Carine, El-Yacoubi, Malika, Widmann, Catherine, Guyon, Alice, Chevet, Eric, Taouji, Saïd, Conductier, Grégory, Corinus, Alain, Coppola, Thierry, Gobbi, Gabriella, Nahon, Jean-Louis, Heurteaux, Catherine, Borsotto, Marc

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Therapeutic potential of prenylated stilbenoid macasiamenene F through its anti-inflammatory and cytoprotective effects on LPS-challenged monocytes and microglia by Leláková, Veronika, Béraud-Dufour, Sophie, Hošek, Jan, Šmejkal, Karel, Prachyawarakorn, Vilailak, Pailee, Phanruethai, Widmann, Catherine, Václavík, Jiří, Coppola, Thierry, Mazella, Jean, Blondeau, Nicolas, Heurteaux, Catherine

“…Macaranga Thou. (Euphorbiaceae) is a large genus that comprises over 300 species distributed between Western Africa and the islands of the South Pacific…”
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High affinity Rab3 binding is dispensable for Rabphilin-dependent potentiation of stimulated secretion by Joberty, G, Stabila, P F, Coppola, T, Macara, I G, Regazzi, R

“…Rabphilin is a protein that associates with the GTP-bound form of Rab3, a small GTPase that controls a late step in Ca(2+)-triggered exocytosis. Rabphilin is…”
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Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway by Daziano, Guillaume, Blondeau, Nicolas, Béraud-Dufour, Sophie, Abderrahmani, Amar, Rovère, Carole, Heurteaux, Catherine, Mazella, Jean, Lebrun, Patricia, Coppola, Thierry

“…Deterioration of insulin secretion and pancreatic beta-cell mass by inflammatory attacks is one of the main pathophysiological features of type 2 diabetes…”
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