Search Results - "Coppo, Lucia"

Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal by Salzano, Sonia, Checconi, Paola, Hanschmann, Eva-Maria, Lillig, Christopher Horst, Bowler, Lucas D., Chan, Philippe, Vaudry, David, Mengozzi, Manuela, Coppo, Lucia, Sacre, Sandra, Atkuri, Kondala R., Sahaf, Bita, Herzenberg, Leonard A., Herzenberg, Leonore A., Mullen, Lisa, Ghezzi, Pietro

“…The mechanism by which oxidative stress induces inflammation and vice versa is unclear but is of great importance, being apparently linked to many chronic…”
Get full text

Glutathione-glutaredoxin is an efficient electron donor system for mammalian p53R2–R1-dependent ribonucleotide reductase by Sengupta, Rajib, Coppo, Lucia, Mishra, Pradeep, Holmgren, Arne

“…Deoxyribonucleotides are DNA building blocks and are produced de novo by reduction of ribose to deoxyribose. This reduction is catalyzed by ribonucleotide…”
Get full text

Glutaredoxin: Discovery, redox defense and much more by Ogata, Fernando T., Branco, Vasco, Vale, Filipa F., Coppo, Lucia

“…Glutaredoxin, Grx, is a small protein containing an active site cysteine pair and was discovered in 1976 by Arne Holmgren. The Grx system, comprised of Grx,…”
Get full text

The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress by Ren, Xiaoyuan, Santhosh, Sebastin M., Coppo, Lucia, Ogata, Fernando T., Lu, Jun, Holmgren, Arne

“…The combination of ascorbate and menadione (VC:VK3 = 100:1) is an investigational treatment for cancer under clinical trials. Dehydroascorbic acid (DHA), the…”
Get full text

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246 by Haffo, Lena, Lu, Jun, Bykov, Vladimir J. N., Martin, Sebastin S., Ren, Xiaoyuan, Coppo, Lucia, Wiman, Klas G., Holmgren, Arne

“…The tumor suppressor p53 is commonly inactivated in human tumors, allowing evasion of p53-dependent apoptosis and tumor progression. The small molecule APR-246…”
Get full text

Glutathione Fine-Tunes the Innate Immune Response toward Antiviral Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties by Diotallevi, Marina, Checconi, Paola, Palamara, Anna Teresa, Celestino, Ignacio, Coppo, Lucia, Holmgren, Arne, Abbas, Kahina, Peyrot, Fabienne, Mengozzi, Manuela, Ghezzi, Pietro

“…Glutathione (GSH), a major cellular antioxidant, is considered an inhibitor of the inflammatory response involving reactive oxygen species (ROS). However,…”
Get full text

Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury by Branco, Vasco, Coppo, Lucia, Solá, Susana, Lu, Jun, Rodrigues, Cecília M.P., Holmgren, Arne, Carvalho, Cristina

“…Mercury (Hg) compounds target both cysteine (Cys) and selenocysteine (Sec) residues in peptides and proteins. Thus, the components of the two major cellular…”
Get full text

Nitric Oxide Protects against Infection-Induced Neuroinflammation by Preserving the Stability of the Blood-Brain Barrier by Olivera, Gabriela C, Ren, Xiaoyuan, Vodnala, Suman K, Lu, Jun, Coppo, Lucia, Leepiyasakulchai, Chaniya, Holmgren, Arne, Kristensson, Krister, Rottenberg, Martin E

“…Nitric oxide (NO) generated by inducible NO synthase (iNOS) is critical for defense against intracellular pathogens but may mediate inflammatory tissue damage…”
Get full text

Mitochondrial depletion of glutaredoxin 2 induces metabolic dysfunction-associated fatty liver disease in mice by Scalcon, Valeria, Folda, Alessandra, Lupo, Maria Giovanna, Tonolo, Federica, Pei, Naixuan, Battisti, Ilaria, Ferri, Nicola, Arrigoni, Giorgio, Bindoli, Alberto, Holmgren, Arne, Coppo, Lucia, Rigobello, Maria Pia

“…Glutaredoxin 2 (Grx2) is a glutathione-dependent oxidoreductase that facilitates glutathionylation/de-glutathionylation of target proteins. The main variants…”
Get full text

Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H2O2, and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells by Blandino, Giulia, Fiorani, Mara, Canonico, Barbara, De Matteis, Rita, Guidarelli, Andrea, Montanari, Mariele, Buffi, Gloria, Coppo, Lucia, Arnér, Elias S.J., Cantoni, Orazio

“…Long-term treatment of schizophrenia with clozapine (CLZ), an atypical antipsychotic drug, is associated with an increased incidence of metabolic disorders…”
Get full text

Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase by Prigge, Justin R., Coppo, Lucia, Martin, Sebastin S., Ogata, Fernando, Miller, Colin G., Bruschwein, Michael D., Orlicky, David J., Shearn, Colin T., Kundert, Jean A., Lytchier, Julia, Herr, Alix E., Mattsson, Åse, Taylor, Matthew P., Gustafsson, Tomas N., Arnér, Elias S.J., Holmgren, Arne, Schmidt, Edward E.

“…Energetic nutrients are oxidized to sustain high intracellular NADPH/NADP+ ratios. NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione…”
Get full text

Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells by Rodriguez-Garcia, Aida, Hevia, David, Mayo, Juan C, Gonzalez-Menendez, Pedro, Coppo, Lucia, Lu, Jun, Holmgren, Arne, Sainz, Rosa M

“…Accumulating evidence suggests that natural bioactive compounds, alone or in combination with traditional chemotherapeutic agents, could be used as potential…”
Get full text

N-Acetylcysteine or Sodium Selenite Prevent the p38-Mediated Production of Proinflammatory Cytokines by Microglia during Exposure to Mercury (II) by Branco, Vasco, Coppo, Lucia, Aschner, Michael, Carvalho, Cristina

“…Mercury (Hg) is known for its neurotoxicity and is reported to activate microglia cells at low exposure levels. Since mercury decreases the activity of the…”
Get full text

A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans by Coppo, Lucia, Mishra, Pradeep, Siefert, Nora, Holmgren, Arne, Pääbo, Svante, Zeberg, Hugo

“…Glutathione reductase is a critical enzyme for preventing oxidative stress and maintaining a reduced intracellular environment. Almost all present-day humans…”
Get full text

control of hyperhomocysteinemia through thiol exchange mechanisms by mesna by Di Giuseppe, Danila, Priora, Raffaella, Coppo, Lucia, Ulivelli, Monica, Bartalini, Sabina, Summa, Domenico, Margaritis, Antonios, Frosali, Simona, Di Simplicio, Paolo

“…In hyperhomocysteinemic patients, after reaction with homocysteine-albumin mixed disulfides (HSS-ALB), mesna (MSH) forms the mixed disulfide with Hcy (HSSM)…”
Get full text

The role of protein sulfhydryl groups and protein disulfides of the platelet surface in aggregation processes involving thiol exchange reactions by Margaritis, Antonios, Priora, Raffaella, Frosali, Simona, Di Giuseppe, Danila, Summa, Domenico, Coppo, Lucia, Di Stefano, Anna, Di Simplicio, Paolo

“…Platelet stimulation by agonists exerts conformational changes of platelet PSH and PSSP by PSH/PSSP thiol exchange reactions and ROS eventually produced during…”
Get full text

Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption by Miller, Colin G, Kundert, Jean A, Prigge, Justin R, Amato, Julie A, Perez, Allison E, Coppo, Lucia, Rizzo, Gabrielle N, Kavanaugh, Michael P, Orlicky, David J, Shearn, Colin T, Schmidt, Edward E

“…Cellular oxidants are primarily managed by the thioredoxin reductase-1 (TrxR1)- and glutathione reductase (Gsr)-driven antioxidant systems. In mice having…”
Get full text

No Evidence of Thioredoxin-interacting Protein (TXNIP) Inhibiting Thioredoxin1 (Trx1) by Maimaiti, Shayida, Coppo, Lucia, Dagnel, Markus, Arner, Elias

Get full text

Thiol regulation of pro-inflammatory cytokines and innate immunity: protein S-thiolation as a novel molecular mechanism by Coppo, Lucia, Ghezzi, Pietro

“…Inflammation or inflammatory cytokines and oxidative stress have often been associated, and thiol antioxidants, particularly glutathione, have often been seen…”
Get more information

The Optimized Quantum Dots Mediated Thermometry Reveals the Efficiency of Myosin Extracted from Muscle Mini Bundles by Li, Meishan, Coppo, Lucia, Jena, Bhanu P., Larsson, Lars

“…The biophysical function of myosin in vitro has been extensively investigated in different motility assays. However, the study of myosin ATPase properties at…”
Get full text