Search Results - "Copping, A."

Germline Chd8 haploinsufficiency alters brain development in mouse by Gompers, Andrea L, Su-Feher, Linda, Ellegood, Jacob, Copping, Nycole A, Riyadh, M Asrafuzzaman, Stradleigh, Tyler W, Pride, Michael C, Schaffler, Melanie D, Wade, A Ayanna, Catta-Preta, Rinaldo, Zdilar, Iva, Louis, Shreya, Kaushik, Gaurav, Mannion, Brandon J, Plajzer-Frick, Ingrid, Afzal, Veena, Visel, Axel, Pennacchio, Len A, Dickel, Diane E, Lerch, Jason P, Crawley, Jacqueline N, Zarbalis, Konstantinos S, Silverman, Jill L, Nord, Alex S

“…Strong genetic evidence points to a significant role for heterozygous mutations to general chromatin remodeling factors, such as CHD8, in autism. Gompers et al…”
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Emerging Gene and Small Molecule Therapies for the Neurodevelopmental Disorder Angelman Syndrome by Copping, Nycole A., McTighe, Stephanie M., Fink, Kyle D., Silverman, Jill L.

“…Angelman syndrome (AS) is a rare (~1:15,000) neurodevelopmental disorder characterized by severe developmental delay and intellectual disability, impaired…”
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Abnormal electrophysiological phenotypes and sleep deficits in a mouse model of Angelman Syndrome by Copping, N A, Silverman, J L

“…Angelman Syndrome (AS) is a rare genetic disorder characterized by impaired communication, motor and balance deficits, intellectual disabilities, recurring…”
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Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism by Dhamne, Sameer C, Silverman, Jill L, Super, Chloe E, Lammers, Stephen H T, Hameed, Mustafa Q, Modi, Meera E, Copping, Nycole A, Pride, Michael C, Smith, Daniel G, Rotenberg, Alexander, Crawley, Jacqueline N, Sahin, Mustafa

“…Autism spectrum disorder (ASD) is a clinically and biologically heterogeneous condition characterized by social, repetitive, and sensory behavioral…”
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Participatory design in refugee camps: comparison of different methods and visualization tools by Albadra, Dima, Elamin, Z., Adeyeye, K., Polychronaki, E., Coley, D. A., Holley, J., Copping, A.

“…Shelters for the displaced can suffer from socio-cultural incompatibility and significant levels of occupant dissatisfaction. Participatory design (PD) is…”
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Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome by Copping, Nycole A, Christian, Sarah G B, Ritter, Dylan J, Islam, M Saharul, Buscher, Nathalie, Zolkowska, Dorota, Pride, Michael C, Berg, Elizabeth L, LaSalle, Janine M, Ellegood, Jacob, Lerch, Jason P, Reiter, Lawrence T, Silverman, Jill L, Dindot, Scott V

“…Maternally derived copy number gains of human chromosome 15q11.2-q13.3 (Dup15q syndrome or Dup15q) cause intellectual disability, epilepsy, developmental…”
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Developmental social communication deficits in the Shank3 rat model of phelan‐mcdermid syndrome and autism spectrum disorder by Berg, Elizabeth L., Copping, Nycole A., Rivera, Josef K., Pride, Michael C., Careaga, Milo, Bauman, Melissa D., Berman, Robert F., Lein, Pamela J., Harony‐Nicolas, Hala, Buxbaum, Joseph D., Ellegood, Jacob, Lerch, Jason P., Wöhr, Markus, Silverman, Jill L.

“…Mutations in the SHANK3 gene have been discovered in autism spectrum disorder (ASD), and the intellectual disability, Phelan‐McDermid Syndrome. This study…”
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Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome by Berg, E. L., Pride, M. C., Petkova, S. P., Lee, R. D., Copping, N. A., Shen, Y., Adhikari, A., Fenton, T. A., Pedersen, L. R., Noakes, L. S., Nieman, B. J., Lerch, J. P., Harris, S., Born, H. A., Peters, M. M., Deng, P., Cameron, D. L., Fink, K. D., Beitnere, U., O’Geen, H., Anderson, A. E., Dindot, S. V., Nash, K. R., Weeber, E. J., Wöhr, M., Ellegood, J., Segal, D. J., Silverman, J. L.

“…Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by developmental delay, impaired communication, motor deficits and ataxia,…”
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Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice by Haigh, Jessica L, Adhikari, Anna, Copping, Nycole A, Stradleigh, Tyler, Wade, A Ayanna, Catta-Preta, Rinaldo, Su-Feher, Linda, Zdilar, Iva, Morse, Sarah, Fenton, Timothy A, Nguyen, Anh, Quintero, Diana, Agezew, Samrawit, Sramek, Michael, Kreun, Ellie J, Carter, Jasmine, Gompers, Andrea, Lambert, Jason T, Canales, Cesar P, Pennacchio, Len A, Visel, Axel, Dickel, Diane E, Silverman, Jill L, Nord, Alex S

“…Genes with multiple co-active promoters appear common in brain, yet little is known about functional requirements for these potentially redundant genomic…”
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Unique Features of the Gut Microbiome Characterized in Animal Models of Angelman Syndrome by Beitnere, Ulrika, Vilanova-Cuevas, Brayan, Christian, Sarah G, Taylor, Clint, Berg, Elizabeth L, Copping, Nycole A, Dindot, Scott V, Silverman, Jill L, Gareau, Mélanie G, Segal, David J

“…A large subset of patients with Angelman syndrome (AS) suffer from concurrent gastrointestinal (GI) issues, including constipation, poor feeding, and reflux…”
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Applying a simple model for estimating the likelihood of collision of marine mammals with tidal turbines by Copping, A. E., Grear, M. E.

“…As tidal turbine deployments continue at test sites and in commercial areas, the potential risk for injury or death of marine mammals from colliding with…”
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Functional rescue in an Angelman syndrome model following treatment with lentivector transduced hematopoietic stem cells by Adhikari, Anna, Copping, Nycole A, Beegle, Julie, Cameron, David L, Deng, Peter, O’Geen, Henriette, Segal, David J, Fink, Kyle D, Silverman, Jill L, Anderson, Joseph S

“…Abstract Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by impaired communication skills, ataxia, motor and balance deficits,…”
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Cognitive deficits in the Snord116 deletion mouse model for Prader-Willi syndrome by Adhikari, Anna, Copping, Nycole A., Onaga, Beth, Pride, Michael C., Coulson, Rochelle L., Yang, Mu, Yasui, Dag H., LaSalle, Janine M., Silverman, Jill L.

“…•A lack of the gene cluster SNORD116 may be responsible for some aspects of PWS.•Heterozygous Snord116 mutation mice had learning and memory deficits in three…”
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Touchscreen learning deficits and normal social approach behavior in the Shank3B model of Phelan–McDermid Syndrome and autism by Copping, Nycole A, Berg, Elizabeth L, Foley, Gillian M, Schaffler, Melanie D, Onaga, Beth L, Buscher, Nathalie, Silverman, Jill L, Yang, Mu

“…Highlights • Shank3B +/− mice exhibit deficits in higher order learning and memory. • Shank3B +/− mice exhibit normal social approach. • Shank3B +/− mice…”
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Touchscreen cognitive deficits, hyperexcitability and hyperactivity in males and females using two models of Cdkl5 deficiency by Adhikari, Anna, Buchanan, Fiona K B, Fenton, Timothy A, Cameron, David L, Halmai, Julian A N M, Copping, Nycole A, Fink, Kyle D, Silverman, Jill L

“…Abstract Many neurodevelopmental disorders (NDDs) are the result of mutations on the X chromosome. One severe NDD resulting from mutations on the X chromosome…”
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Transcriptional reprogramming restores UBE3A brain-wide and rescues behavioral phenotypes in an Angelman syndrome mouse model by O’Geen, Henriette, Beitnere, Ulrika, Garcia, Miranda S., Adhikari, Anna, Cameron, David L., Fenton, Timothy A., Copping, Nycole A., Deng, Peter, Lock, Samantha, Halmai, Julian A.N.M., Villegas, Isaac J., Liu, Jiajian, Wang, Danhui, Fink, Kyle D., Silverman, Jill L., Segal, David J.

“…Angelman syndrome (AS) is a neurogenetic disorder caused by the loss of ubiquitin ligase E3A (UBE3A) gene expression in the brain. The UBE3A gene is paternally…”
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Assessing the effects of marine and hydrokinetic energy development on marine and estuarine resources by Ward, J, Schultz, I, Woodruff, D, Roesijadi, G, Copping, A

“…The world's oceans and estuaries offer enormous potential to meet the nation's growing demand for energy. The use of marine and hydrokinetic (MHK) devices to…”
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Cognitive behavioural therapy for adults with dissociative seizures (CODES): a pragmatic, multicentre, randomised controlled trial by Goldstein, Laura H, Carson, Alan, McCrone, Paul, Murray, Joanna, Pilecka, Izabela, Mosweu, Iris, Perdue, Iain, Abe, A-M, Allroggen, H, Alvares, D, Angus-Leppan, H, Aram, J, Armstrong, R, Atalaia, A, Bagary, M, Baldellou Lopez, M, Bennett, M, Black, T, Blackburn, D, Broadhurst, M, Buckley, M, Burness, C, Callaghan, H, Chong, S, Chowdury, F, Cocco, G, Cooper, S, Cope, S, Copping, A, Dennis, G, Devlin, R, Diehl, B, Duncan, S, Ellis, C, Elwes, R, Eriemo, S, Faruqui, R, Feehan, S, Finnerty, G, Firth, N, Gardiner, P, Graham, C, Grunewald, R, Hadden, R, Harding, R, Harikrishnan, S, Healy, H, Hewamadduma, C, Innocente, M, Jordan, H, Karlsson, J, Kelso, A, Kovac, S, Laker, A, Leschziner, G, Liu, R, Lozsadi, D, Ludwig, L, MacDonald, B, Maguire, M, Manford, M, Martino, D, McGorlick, A, McKevitt, F, Memon, S, Miorelli, A, Morgan-Boon, A, Mullatti, N, O'Hara, D, Oakley, L, O'Sullivan, S, Pickerell, W, Poole, N, Protheroe, D, Quirk, J, Rajakulendran, S, Read, J, Rowbottom, C, Saha, R, Samarasekera, S, Sanchez Sanchez, V, Santhouse, A, Scholes, K, Shetty, A, Simkiss, R, Sivagnanasundaram, J, Smith, P, Sokhi, D, Stanton, B, Suvorova, L, Tahir, T, Taylor, R, Teare, L, Thorpe, J, Vinnicombe, J, Walker, M, Walsh, C, Watson, G, Whittaker, M, Wicks, L

“…Dissociative seizures are paroxysmal events resembling epilepsy or syncope with characteristic features that allow them to be distinguished from other medical…”
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Tethys knowledge management system: Working to advance the marine renewable energy industry by Whiting, Jonathan, Copping, Andrea, Freeman, Mikaela, Woodbury, Amy

“…Development of the marine renewable energy (MRE) industry has been challenged by uncertainty about potential environmental effects, which has resulted in…”
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The development of a Fire Safety Evaluation Procedure for the Property Protection of Parish Churches by COPPING, Alexander G

“…Incidences of fires in churches are currently exceeding those in all other historic building types. This trend is destroying irreplaceable national treasures…”
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