Search Results - "Coppin, Chris"

Non-additive gene interactions underpin molecular and phenotypic responses in honey bee larvae exposed to imidacloprid and thymol by Paten, Amy M., Colin, Théotime, Coppin, Chris W., Court, Leon N., Barron, Andrew B., Oakeshott, John G., Morgan, Matthew J.

“…Understanding the cumulative risk of chemical mixtures at environmentally realistic concentrations is a key challenge in honey bee ecotoxicology…”
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Expression–environment associations in transcriptomic heat stress responses for a global plant lineage by Andrew, Samuel C., Simonsen, Anna K., Coppin, Chris W., Arnold, Pieter A., Briceño, Verónica F., McLay, Todd G. B., Jackson, Chris J., Gallagher, Rachael V., Mokany, Karel

“…The increasing frequency and severity of heatwaves will intensify stress on plants. Given regional variation in heatwave exposure and expected differences in…”
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Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resistance by Jackson, Colin J., Liu, Jian-Wei, Carr, Paul D., Younus, Faisal, Coppin, Chris, Meirelles, Tamara, Lethier, Mathilde, Pandey, Gunjan, Ollis, David L., Russell, Robyn J., Weik, Martin, Oakeshott, John G.

“…Insect carboxylesterases from the aEsterase gene cluster, such as αE7 (also known as E3) from the Australian sheep blowfly Lucilia cuprina (LcαE7), play an…”
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Immunotherapy for renal cell cancer in the era of targeted therapy by Coppin, Chris

“…Until recently, cytokine therapy has been the only validated option for patients with advanced renal cancer. IFN-α is one of very few treatments that have…”
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Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability by Fraser, Nicholas J., Liu, Jian-Wei, Mabbitt, Peter D., Correy, Galen J., Coppin, Chris W., Lethier, Mathilde, Perugini, Matthew A., Murphy, James M., Oakeshott, John G., Weik, Martin, Jackson, Colin J.

“…Oligomerization has been suggested to be an important mechanism for increasing or maintaining the thermostability of proteins. Although it is evident that…”
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Everolimus : the first approved product for patients with advanced renal cell cancer after sunitinib and/or sorafenib by Coppin, Chris

“…Presents the results of a phase III randomised placebo-controlled trial that examined the impact of everolimus in patients with clear cell renal cancers and…”
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An antennal carboxylesterase from Drosophila melanogaster, esterase 6, is a candidate odorant-degrading enzyme toward food odorants by Chertemps, Thomas, Younus, Faisal, Steiner, Claudia, Durand, Nicolas, Coppin, Chris W, Pandey, Gunjan, Oakeshott, John G, Maïbèche, Martine

“…Reception of odorant molecules within insect olfactory organs involves several sequential steps, including their transport through the sensillar lymph,…”
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Heterologous expression and biochemical characterisation of fourteen esterases from Helicoverpa armigera by Teese, Mark G, Farnsworth, Claire A, Li, Yongqiang, Coppin, Chris W, Devonshire, Alan L, Scott, Colin, East, Peter, Russell, Robyn J, Oakeshott, John G

“…Esterases have recurrently been implicated in insecticide resistance in Helicoverpa armigera but little is known about the underlying molecular mechanisms. We…”
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Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila by Younus, Faisal, Fraser, Nicholas J., Coppin, Chris W., Liu, Jian-Wei, Correy, Galen J., Chertemps, Thomas, Pandey, Gunjan, Maïbèche, Martine, Jackson, Colin J., Oakeshott, John G.

“…Previous electrophysiological and behavioural studies implicate esterase 6 in the processing of the pheromone cis-vaccenyl acetate and various food odorants…”
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Organophosphate and pyrethroid hydrolase activities of mutant Esterases from the cotton bollworm Helicoverpa armigera by Li, Yongqiang, Farnsworth, Claire A, Coppin, Chris W, Teese, Mark G, Liu, Jian-Wei, Scott, Colin, Zhang, Xing, Russell, Robyn J, Oakeshott, John G

“…Two mutations have been found in five closely related insect esterases (from four higher Diptera and a hymenopteran) which each confer organophosphate (OP)…”
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The molecular basis for the neofunctionalization of the juvenile hormone esterase duplication in Drosophila by Hopkins, Davis H., Rane, Rahul V., Younus, Faisal, Coppin, Chris W., Pandey, Gunjan, Jackson, Colin J., Oakeshott, John G.

“…The Drosophila melanogaster enzymes juvenile hormone esterase (DmJHE) and its duplicate, DmJHEdup, present ideal examples for studying the structural changes…”
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Genomic changes associated with adaptation to arid environments in cactophilic Drosophila species by Rane, Rahul V, Pearce, Stephen L, Li, Fang, Coppin, Chris, Schiffer, Michele, Shirriffs, Jennifer, Sgrò, Carla M, Griffin, Philippa C, Zhang, Goujie, Lee, Siu F, Hoffmann, Ary A, Oakeshott, John G

“…Insights into the genetic capacities of species to adapt to future climate change can be gained by using comparative genomic and transcriptomic data to…”
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Targeted therapy for advanced renal cell carcinoma by Coppin, C, Le, L, Porzsolt, F, Wilt, T

“…Advanced renal cell carcinoma has been resistant to drug therapy of different types and new types of drug therapy are needed. Targeted agents inhibit known…”
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Catalytic Improvement and Evolution of Atrazine Chlorohydrolase by Scott, Colin, Jackson, Colin J, Coppin, Chris W, Mourant, Roslyn G, Hilton, Margaret E, Sutherland, Tara D, Russell, Robyn J, Oakeshott, John G

“…The atrazine chlorohydrolase AtzA has evolved within the past 50 years to catalyze the hydrolytic dechlorination of the herbicide atrazine. It is of wide…”
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Testing the evolvability of an insect carboxylesterase for the detoxification of synthetic pyrethroid insecticides by Coppin, Chris W, Jackson, Colin J, Sutherland, Tara, Hart, Peter J, Devonshire, Alan L, Russell, Robyn J, Oakeshott, John G

“…Esterases have been implicated in metabolic resistance to synthetic pyrethroids in several insect species but little is yet known of the molecular basis for…”
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Sunitinib for advanced renal cell cancer by Coppin, Chris

“…Reviews the rationale, development, validation, and clinical use of sunitinib (with renal cell cancer patients) that received conditional approval for use in…”
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The enzymatic basis for pesticide bioremediation by Scott, Colin, Pandey, Gunjan, Hartley, Carol J., Jackson, Colin J., Cheesman, Matthew J., Taylor, Matthew C., Pandey, Rinku, Khurana, Jeevan L., Teese, Mark, Coppin, Chris W., Weir, Kahli M., Jain, Rakesh K., Lal, Rup, Russell, Robyn J., Oakeshott, John G.

“…Enzymes are central to the biology of many pesticides, influencing their modes of action, environmental fates and mechanisms of target species resistance…”
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The Load Dependence of Kinesin's Mechanical Cycle by Coppin, Chris M., Pierce, Daniel W., Hsu, Long, Vale, Ronald D.

“…Kinesin is a dimeric motor protein that transports organelles in a stepwise manner toward the plus-end of microtubules by converting the energy of ATP…”
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Minimally immunogenic decellularized porcine valve provides in situ recellularization as a stentless bioprosthetic valve by Iwai, Shigemitsu, Torikai, Kei, Coppin, Chris M, Sawa, Yoshiki

“…Currently used bioprosthetic valves have several limitations such as calcification and functional deterioration, and revitalization through cellular ingrowth…”
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Fibronectin-Hepatocyte Growth Factor Enhances Reendothelialization in Tissue-Engineered Heart Valve by Ota, Takeyoshi, Sawa, Yoshiki, Iwai, Shigemitsu, Kitajima, Takashi, Ueda, Yuichiro, Coppin, Chris, Matsuda, Hikaru, Okita, Yutaka

“…To overcome the limitations of tissue-engineered heart valves, which require cell seeding before implantation, a growth factor for in situ recellularization…”
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