Search Results - "Coppens, Isabelle"

Host lipid droplets: An important source of lipids salvaged by the intracellular parasite Toxoplasma gondii by Nolan, Sabrina J, Romano, Julia D, Coppens, Isabelle

“…Toxoplasma is an obligate intracellular parasite that replicates in mammalian cells within a parasitophorous vacuole (PV) that does not fuse with any host…”
Get full text

Endolysosomal Targeting of Mitochondria Is Integral to BAX-Mediated Mitochondrial Permeabilization during Apoptosis Signaling by Wang, Tim Sen, Coppens, Isabelle, Saorin, Anna, Brady, Nathan Ryan, Hamacher-Brady, Anne

“…Mitochondrial outer membrane permeabilization (MOMP) is a core event in apoptosis signaling. However, the underlying mechanism of BAX and BAK pore formation…”
Get full text

Hostile intruder: Toxoplasma holds host organelles captive by Coppens, Isabelle, Romano, Julia D

“…[...]host endocytic structures, multivesicular bodies, Golgi ministacks, lipid droplets, and a plethora of transport vesicles associated with different Rab…”
Get full text

Function and regulation of a steroidogenic CYP450 enzyme in the mitochondrion of Toxoplasma gondii by Asady, Beejan, Samples, Vera, Romano, Julia D, Levitskaya, Jelena, Lige, Bao, Khare, Pratik, Le, Anne, Coppens, Isabelle

“…As an obligate intracellular parasite, Toxoplasma gondii must import essential nutrients from the host cell into the parasitophorous vacuole. We previously…”
Get full text

Listeria monocytogenes virulence factors, including listeriolysin O, are secreted in biologically active extracellular vesicles by Coelho, Carolina, Brown, Lisa, Maryam, Maria, Vij, Raghav, Smith, Daniel F.Q., Burnet, Meagan C., Kyle, Jennifer E., Heyman, Heino M., Ramirez, Jasmine, Prados-Rosales, Rafael, Lauvau, Gregoire, Nakayasu, Ernesto S., Brady, Nathan R., Hamacher-Brady, Anne, Coppens, Isabelle, Casadevall, Arturo

“…Outer membrane vesicles produced by Gram-negative bacteria have been studied for half a century but the possibility that Gram-positive bacteria secrete…”
Get full text

The parasite Toxoplasma sequesters diverse Rab host vesicles within an intravacuolar network by Romano, Julia D, Nolan, Sabrina J, Porter, Corey, Ehrenman, Karen, Hartman, Eric J, Hsia, Ru-Ching, Coppens, Isabelle

“…Many intracellular pathogens subvert host membrane trafficking pathways to promote their replication. multiplies in a membrane-bound parasitophorous vacuole…”
Get full text

Metamorphoses of malaria: the role of autophagy in parasite differentiation by Coppens, Isabelle

“…Several protozoan parasites undergo a complex life cycle that alternates between an invertebrate vector and a vertebrate host. Adaptations to these different…”
Get more information

Unusual features and localization of the membrane kinome of Trypanosoma brucei by Jensen, Bryan C, Vaney, Pashmi, Flaspohler, John, Coppens, Isabelle, Parsons, Marilyn

“…In many eukaryotes, multiple protein kinases are situated in the plasma membrane where they respond to extracellular ligands. Ligand binding elicits a signal…”
Get full text

The inclusion membrane protein IncS is critical for initiation of the Chlamydia intracellular developmental cycle by Cortina, María Eugenia, Bishop, R Clayton, DeVasure, Brittany A, Coppens, Isabelle, Derré, Isabelle

“…All Chlamydia species are obligate intracellular bacteria that undergo a unique biphasic developmental cycle strictly in the lumen of a membrane bound…”
Get full text

Systematic characterization of all Toxoplasma gondii TBC domain-containing proteins identifies an essential regulator of Rab2 in the secretory pathway by Quan, Justin J, Nikolov, Lachezar A, Sha, Jihui, Wohlschlegel, James A, Coppens, Isabelle, Bradley, Peter J

“…Toxoplasma gondii resides in its intracellular niche by employing a series of specialized secretory organelles that play roles in invasion, host cell…”
Get full text

Eosinophil-derived IL-4 drives progression of myocarditis to inflammatory dilated cardiomyopathy by Diny, Nicola L, Baldeviano, G Christian, Talor, Monica V, Barin, Jobert G, Ong, SuFey, Bedja, Djahida, Hays, Allison G, Gilotra, Nisha A, Coppens, Isabelle, Rose, Noel R, Čiháková, Daniela

“…Inflammatory dilated cardiomyopathy (DCMi) is a major cause of heart failure in children and young adults. DCMi develops in up to 30% of myocarditis patients,…”
Get full text

Toxoplasma FER1 is a versatile and dynamic mediator of differential microneme trafficking and microneme exocytosis by Tagoe, Daniel N. A., Ribeiro E Silva, Adeline, Drozda, Allison A., Coppens, Isabelle, Coleman, Bradley I., Gubbels, Marc-Jan

“…Toxoplasma gondii is a polarized cell concentrating several secretory organelles at the apical pole. The secretory micronemes come in two sub-populations…”
Get full text

Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite Interface by Hammoudi, Pierre-Mehdi, Jacot, Damien, Mueller, Christina, Di Cristina, Manlio, Dogga, Sunil Kumar, Marq, Jean-Baptiste, Romano, Julia, Tosetti, Nicolò, Dubrot, Juan, Emre, Yalin, Lunghi, Matteo, Coppens, Isabelle, Yamamoto, Masahiro, Sojka, Daniel, Pino, Paco, Soldati-Favre, Dominique

“…Toxoplasma gondii possesses sets of dense granule proteins (GRAs) that either assemble at, or cross the parasitophorous vacuole membrane (PVM) and exhibit…”
Get full text

Modelling Toxoplasma gondii infection in a 3D cell culture system In Vitro: Comparison with infection in 2D cell monolayers by Danielson, Jeffrey J, Perez, Nicolas, Romano, Julia D, Coppens, Isabelle

“…Three-dimensional (3D) cell culture models bridge the gap between two-dimensional (2D) monolayer cultures and animal models. Physiologically relevant, 3D…”
Get full text

Identification and Localization of the First Known Proteins of the Trypanosoma cruzi Cytostome Cytopharynx Endocytic Complex by Chasen, Nathan Michael, Coppens, Isabelle, Etheridge, Ronald Drew

“…The etiological agent of Chagas disease, , is an obligate intracellular parasite that infects an estimated 7 million people in the Americas, with an at-risk…”
Get full text

Phosphoregulation accommodates Type III secretion and assembly of a tether of ER-Chlamydia inclusion membrane contact sites by Ende, Rachel J, Murray, Rebecca L, D'Spain, Samantha K, Coppens, Isabelle, Derré, Isabelle

“…Membrane contact sites (MCS) are crucial for nonvesicular trafficking-based interorganelle communication. Endoplasmic reticulum (ER)–organelle tethering occurs…”
Get full text

A single Na+-Pi cotransporter in Toxoplasma plays key roles in phosphate import and control of parasite osmoregulation by Asady, Beejan, Dick, Claudia F, Ehrenman, Karen, Sahu, Tejram, Romano, Julia D, Coppens, Isabelle

“…Inorganic ions such as phosphate, are essential nutrients required for a broad spectrum of cellular functions and regulation. During infection, pathogens must…”
Get full text

Correction: Hostile intruder: Toxoplasma holds host organelles captive by Coppens, Isabelle, Romano, Julia D

“…[This corrects the article DOI: 10.1371/journal.ppat.1006893.]…”
Get full text

A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii by Li, Zhu-Hong, King, Thayer P., Ayong, Lawrence, Asady, Beejan, Cai, Xinjiang, Rahman, Taufiq, Vella, Stephen A., Coppens, Isabelle, Patel, Sandip, Moreno, Silvia N. J.

“…Two-pore channels (TPCs) are a ubiquitous family of cation channels that localize to acidic organelles in animals and plants to regulate numerous Ca 2+…”
Get full text

Metamorphosis of the malaria parasite in the liver is associated with organelle clearance by Jayabalasingham, Bamini, Bano, Nazneen, Coppens, Isabelle

“…Malaria parasites encounter diverse conditions as they cycle between their vertebrate host and mosquito vector. Within these distinct environments, the…”
Get full text