Search Results - "Coppee, Frederique"
-
1
Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study
Published in European archives of oto-rhino-laryngology (01-08-2020)“…Objective To investigate the occurrence of olfactory and gustatory dysfunctions in patients with laboratory-confirmed COVID-19 infection. Methods Patients with…”
Get full text
Journal Article -
2
The FSHD atrophic myotube phenotype is caused by DUX4 expression
Published in PloS one (28-10-2011)“…Facioscapulohumeral muscular dystrophy (FSHD) is linked to deletions in 4q35 within the D4Z4 repeat array in which we identified the double homeobox 4 (DUX4)…”
Get full text
Journal Article -
3
An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies
Published in The EMBO journal (22-10-2008)“…Facioscapulohumeral muscular dystrophy (FSHD) is caused by an unusual deletion with neomorphic activity. This deletion derepresses genes in cis ; however which…”
Get full text
Journal Article -
4
DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1
Published in Proceedings of the National Academy of Sciences - PNAS (13-11-2007)“…Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disorder linked to contractions of the D4Z4 repeat array in the subtelomeric region of…”
Get full text
Journal Article -
5
Molecular and cellular biology of PCSK9: impact on glucose homeostasis
Published in Journal of drug targeting (06-10-2022)“…Proprotein convertase substilisin/kexin 9 (PCSK9) inhibitors (PCSK9i) revolutionised the lipid-lowering therapy. However, a risk of type 2 diabetes mellitus…”
Get full text
Journal Article -
6
DUX4, a candidate gene for facioscapulohumeral muscular dystrophy, causes p53-dependent myopathy in vivo
Published in Annals of neurology (01-03-2011)“…Objective: Facioscapulohumeral muscular dystrophy (FSHD) is associated with D4Z4 repeat contraction on human chromosome 4q35. This genetic lesion does not…”
Get full text
Journal Article -
7
Antisense Oligonucleotides Used to Target the DUX4 mRNA as Therapeutic Approaches in FaciosScapuloHumeral Muscular Dystrophy (FSHD)
Published in Genes (03-03-2017)“…FacioScapuloHumeral muscular Dystrophy (FSHD) is one of the most prevalent hereditary myopathies and is generally characterized by progressive muscle atrophy…”
Get full text
Journal Article -
8
DUX4 expression in FSHD muscle cells: how could such a rare protein cause a myopathy?
Published in Journal of cellular and molecular medicine (01-01-2013)“…Facioscapulohumeral muscular dystrophy (FSHD) is one of the most frequent hereditary muscle disorders. It is linked to contractions of the D4Z4 repeat array in…”
Get full text
Journal Article -
9
FSHD myotubes with different phenotypes exhibit distinct proteomes
Published in PloS one (18-12-2012)“…Facioscapulohumeral muscular dystrophy (FSHD) is a progressive muscle disorder linked to a contraction of the D4Z4 repeat array in the 4q35 subtelomeric…”
Get full text
Journal Article -
10
Dux4 controls migration of mesenchymal stem cells through the Cxcr4-Sdf1 axis
Published in Oncotarget (04-10-2016)“…We performed transcriptome profiling of human immortalized myoblasts (MB) transiently expressing double homeobox transcription factor 4 (DUX4) and double…”
Get full text
Journal Article -
11
Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei
Published in Skeletal muscle (12-01-2018)“…Facioscapulohumeral muscular dystrophy (FSHD) is associated with DNA hypomethylation at the 4q35 D4Z4 repeat array. Both the causal gene DUX4 and its homolog…”
Get full text
Journal Article -
12
DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation
Published in PloS one (15-10-2009)“…Facioscapulohumeral muscular dystrophy (FSHD) is a dominant disease linked to contractions of the D4Z4 repeat array in 4q35. We have previously identified a…”
Get full text
Journal Article -
13
The Krüppel-like Factor 15 as a Molecular Link between Myogenic Factors and a Chromosome 4q Transcriptional Enhancer Implicated in Facioscapulohumeral Dystrophy
Published in The Journal of biological chemistry (30-12-2011)“…Facioscapulohumeral muscular dystrophy (FSHD), a dominant hereditary disease with a prevalence of 7 per 100,000 individuals, is associated with a partial…”
Get full text
Journal Article -
14
The Role of D4Z4-Encoded Proteins in the Osteogenic Differentiation of Mesenchymal Stromal Cells Isolated from Bone Marrow
Published in Stem cells and development (15-11-2015)“…Facioscapulohumeral muscular dystrophy (FSHD) is associated with an activation of the double homeobox 4 (DUX4) gene, which we previously identified within the…”
Get more information
Journal Article -
15
Clinical and epidemiological characteristics of 1420 European patients with mild‐to‐moderate coronavirus disease 2019
Published in Journal of internal medicine (01-09-2020)“…Background The clinical presentation of European patients with mild‐to‐moderate COVID‐19 infection is still unknown. Objective To study the clinical…”
Get full text
Journal Article -
16
Helicase-like transcription factor exhibits increased expression and altered intracellular distribution during tumor progression in hypopharyngeal and laryngeal squamous cell carcinomas
Published in Virchows Archiv : an international journal of pathology (01-11-2008)“…The helicase-like transcription factor (HLTF) belongs to the SWI/SNF family of proteins that use the energy from adenosine triphosphate hydrolysis to remodel…”
Get full text
Journal Article -
17
Induction of a local muscular dystrophy using electroporation in vivo: an easy tool for screening therapeutics
Published in Scientific reports (09-07-2020)“…Intramuscular injection and electroporation of naked plasmid DNA (IMEP) has emerged as a potential alternative to viral vector injection for transgene…”
Get full text
Journal Article -
18
Facioscapulohumeral muscular dystrophy (FSHD): an enigma unravelled?
Published in Human genetics (01-03-2012)“…Facioscapulohumeral muscular dystrophy (FSHD) is the third most common muscular dystrophy after the dystrophinopathies and myotonic dystrophy and is associated…”
Get full text
Journal Article -
19
Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation
Published in PloS one (27-01-2016)“…Hundreds of double homeobox (DUX) genes map within 3.3-kb repeated elements dispersed in the human genome and encode DNA-binding proteins. Among these, we…”
Get full text
Journal Article Web Resource -
20
The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins
Published in Skeletal muscle (07-03-2023)“…We have previously demonstrated that double homeobox 4 centromeric (DUX4C) encoded for a functional DUX4c protein upregulated in dystrophic skeletal muscles…”
Get full text
Journal Article