Search Results - "Coppa, Anna"

Molecular profiling of male breast cancer by multigene panel testing: Implications for precision oncology by Valentini, Virginia, Silvestri, Valentina, Bucalo, Agostino, Conti, Giulia, Karimi, Mina, Di Francesco, Linda, Pomati, Giulia, Mezi, Silvia, Cerbelli, Bruna, Pignataro, Maria Gemma, Nicolussi, Arianna, Coppa, Anna, D'Amati, Giulia, Giannini, Giuseppe, Ottini, Laura

“…Compared with breast cancer (BC) in women, BC in men is a rare disease with genetic and molecular peculiarities. Therapeutic approaches for male BC (MBC) are…”
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MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors by Petroni, Marialaura, Sardina, Francesca, Infante, Paola, Bartolazzi, Armando, Locatelli, Erica, Fabretti, Francesca, Di Giulio, Stefano, Capalbo, Carlo, Cardinali, Beatrice, Coppa, Anna, Tessitore, Alessandra, Colicchia, Valeria, Sahùn Roncero, Maria, Belardinilli, Francesca, Di Marcotullio, Lucia, Soddu, Silvia, Comes Franchini, Mauro, Petricci, Elena, Gulino, Alberto, Giannini, Giuseppe

“…MRE11 is a component of the MRE11/RAD50/NBS1 (MRN) complex, whose activity is essential to control faithful DNA replication and to prevent accumulation of…”
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Contribution of MUTYH Variants to Male Breast Cancer Risk: Results From a Multicenter Study in Italy by Rizzolo, Piera, Silvestri, Valentina, Bucalo, Agostino, Zelli, Veronica, Valentini, Virginia, Catucci, Irene, Zanna, Ines, Masala, Giovanna, Bianchi, Simonetta, Spinelli, Alessandro Mauro, Tommasi, Stefania, Tibiletti, Maria Grazia, Russo, Antonio, Varesco, Liliana, Coppa, Anna, Calistri, Daniele, Cortesi, Laura, Viel, Alessandra, Bonanni, Bernardo, Azzollini, Jacopo, Manoukian, Siranoush, Montagna, Marco, Radice, Paolo, Palli, Domenico, Peterlongo, Paolo, Ottini, Laura

“…Inherited mutations in , and, mainly, genes are associated with increased risk of male breast cancer (MBC). Mutations in and genes may also increase MBC risk…”
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Clinical Multigene Panel Sequencing Identifies Distinct Mutational Association Patterns in Metastatic Colorectal Cancer by Belardinilli, Francesca, Capalbo, Carlo, Malapelle, Umberto, Pisapia, Pasquale, Raimondo, Domenico, Milanetti, Edoardo, Yasaman, Mahdavian, Liccardi, Carlotta, Paci, Paola, Sibilio, Pasquale, Pepe, Francesco, Bonfiglio, Caterina, Mezi, Silvia, Magri, Valentina, Coppa, Anna, Nicolussi, Arianna, Gradilone, Angela, Petroni, Marialaura, Di Giulio, Stefano, Fabretti, Francesca, Infante, Paola, Coni, Sonia, Canettieri, Gianluca, Troncone, Giancarlo, Giannini, Giuseppe

“…Extensive molecular characterization of human colorectal cancer (CRC) via Next Generation Sequencing (NGS) indicated that genetic or epigenetic dysregulation…”
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Optimizing the identification of risk‐relevant mutations by multigene panel testing in selected hereditary breast/ovarian cancer families by Coppa, Anna, Nicolussi, Arianna, D'Inzeo, Sonia, Capalbo, Carlo, Belardinilli, Francesca, Colicchia, Valeria, Petroni, Marialaura, Zani, Massimo, Ferraro, Sergio, Rinaldi, Christian, Buffone, Amelia, Bartolazzi, Armando, Screpanti, Isabella, Ottini, Laura, Giannini, Giuseppe

“…The introduction of multigene panel testing for hereditary breast/ovarian cancer screening has greatly improved efficiency, speed, and costs. However, its…”
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Next-generation sequencing of BRCA1 and BRCA2 genes for rapid detection of germline mutations in hereditary breast/ovarian cancer by Nicolussi, Arianna, Belardinilli, Francesca, Mahdavian, Yasaman, Colicchia, Valeria, D'Inzeo, Sonia, Petroni, Marialaura, Zani, Massimo, Ferraro, Sergio, Valentini, Virginia, Ottini, Laura, Giannini, Giuseppe, Capalbo, Carlo, Coppa, Anna

“…Conventional methods used to identify and germline mutations in hereditary cancers, such as Sanger sequencing/multiplex ligation-dependent probe amplification…”
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PRDX1 and PRDX6 are repressed in papillary thyroid carcinomas via BRAF V600E-dependent and -independent mechanisms by NICOLUSSI, ARIANNA, D'INZEO, SONIA, MINCIONE, GABRIELLA, BUFFONE, AMELIA, DI MARCANTONIO, MARIA CARMELA, COTELLESE, ROBERTO, CICHELLA, ANNADOMENICA, CAPALBO, CARLO, DI GIOIA, CIRA, NARDI, FRANCESCO, GIANNINI, GIUSEPPE, COPPA, ANNA

“…Many clinical studies highlight the dichotomous role of PRDXs in human cancers, where they can exhibit strong tumor-suppressive or tumor-promoting functions…”
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A novel BRCA2 splice variant identified in a young woman by Nicolussi, Arianna, Belardinilli, Francesca, Ottini, Laura, Petroni, Marialaura, Capalbo, Carlo, Giannini, Giuseppe, Coppa, Anna

“…Background BRCA1/2 VUSs represent an important clinical issue in risk assessment for the breast/ovarian cancer families (HBOC) families. Among them, some…”
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NSD1 Mutations and Pediatric High-Grade Gliomas: A Comparative Genomic Study in Primary and Recurrent Tumors by d'Amati, Antonio, Nicolussi, Arianna, Miele, Evelina, Mastronuzzi, Angela, Rossi, Sabrina, Gianno, Francesca, Buttarelli, Francesca Romana, Minasi, Simone, Lodeserto, Pietro, Gardiman, Marina Paola, Viscardi, Elisabetta, Coppa, Anna, Donofrio, Vittoria, Giovannoni, Isabella, Giangaspero, Felice, Antonelli, Manila

“…Pediatric high-grade gliomas represent a heterogeneous group of tumors with a wide variety of molecular features. We performed whole exome sequencing and…”
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Identification of novel BRCA1 large genomic rearrangements by a computational algorithm of amplicon-based Next-Generation Sequencing data by Nicolussi, Arianna, Belardinilli, Francesca, Silvestri, Valentina, Mahdavian, Yasaman, Valentini, Virginia, D'Inzeo, Sonia, Petroni, Marialaura, Zani, Massimo, Ferraro, Sergio, Di Giulio, Stefano, Fabretti, Francesca, Fratini, Beatrice, Gradilone, Angela, Ottini, Laura, Giannini, Giuseppe, Coppa, Anna, Capalbo, Carlo

“…Genetic testing for germline mutations in hereditary breast/ovarian cancer patients requires screening for single nucleotide variants, small…”
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Role of reduced expression of SMAD4 in papillary thyroid carcinoma by D'Inzeo, Sonia, Nicolussi, Arianna, Ricci, Antonella, Mancini, Patrizia, Porcellini, Antonio, Nardi, Francesco, Coppa, Anna

“…It has been demonstrated that transforming growth factor-β (TGFβ) and other members of TGFβ superfamily play an important role in thyroid proliferative…”
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Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk by Rizzolo, Piera, Silvestri, Valentina, Valentini, Virginia, Zelli, Veronica, Bucalo, Agostino, Zanna, Ines, Bianchi, Simonetta, Tibiletti, Maria Grazia, Russo, Antonio, Varesco, Liliana, Tedaldi, Gianluca, Bonanni, Bernardo, Azzollini, Jacopo, Manoukian, Siranoush, Coppa, Anna, Giannini, Giuseppe, Cortesi, Laura, Viel, Alessandra, Montagna, Marco, Peterlongo, Paolo, Radice, Paolo, Palli, Domenico, Ottini, Laura

“…Breast cancer in men is a rare and still poorly characterized disease. Inherited mutations in BRCA1, BRCA2 and PALB2 genes, as well as common polymorphisms,…”
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EGF and TGF-β1 Effects on Thyroid Function by Mincione, Gabriella, Di Marcantonio, Maria Carmela, Tarantelli, Chiara, D'Inzeo, Sonia, Nicolussi, Arianna, Nardi, Francesco, Donini, Caterina Francesca, Coppa, Anna

“…Normal epithelial thyroid cells in culture are inhibited by TGF-β1. Instead, transformed thyroid cell lines are frequently resistant to its growth inhibitory…”
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HE4 in the differential diagnosis of a pelvic mass: a case report by Anastasi, Emanuela, Granato, Teresa, Coppa, Anna, Manganaro, Lucia, Giannini, Giuseppe, Comploj, Sara, Frati, Luigi, Midulla, Cecilia

“…Neoplasms of the ovary present an increasing challenge to the physician. Neoplastic ovarian cysts can resemble endometriomas in ultrasound imaging and need to…”
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EGF and TGF- 1 Effects on Thyroid Function by Mincione, Gabriella, Di Marcantonio, Maria Carmela, Tarantelli, Chiara, D'Inzeo, Sonia, Nicolussi, Arianna, Nardi, Francesco, Donini, Caterina Francesca, Coppa, Anna

“…Normal epithelial thyroid cells in culture are inhibited by TGF-1. Instead, transformed thyroid cell lines are frequently resistant to its growth inhibitory…”
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The role of peroxiredoxins in cancer by Nicolussi, Arianna, D'Inzeo, Sonia, Capalbo, Carlo, Giannini, Giuseppe, Coppa, Anna

“…Peroxiredoxins (PRDXs) are a ubiquitously expressed family of small (22-27 kDa) non-seleno peroxidases that catalyze the peroxide reduction of H O , organic…”
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Male breast cancer risk associated with pathogenic variants in genes other than BRCA1/2: an Italian case-control study by Bucalo, Agostino, Conti, Giulia, Valentini, Virginia, Capalbo, Carlo, Bruselles, Alessandro, Tartaglia, Marco, Bonanni, Bernardo, Calistri, Daniele, Coppa, Anna, Cortesi, Laura, Giannini, Giuseppe, Gismondi, Viviana, Manoukian, Siranoush, Manzella, Livia, Montagna, Marco, Peterlongo, Paolo, Radice, Paolo, Russo, Antonio, Tibiletti, Maria Grazia, Turchetti, Daniela, Viel, Alessandra, Zanna, Ines, Palli, Domenico, Silvestri, Valentina, Ottini, Laura

“…Germline pathogenic variants (PVs) in BRCA1/2 genes are associated with breast cancer (BC) risk in both women and men. Multigene panel testing is being…”
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A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors by Di Giulio, Stefano, Colicchia, Valeria, Pastorino, Fabio, Pedretti, Flaminia, Fabretti, Francesca, Nicolis di Robilant, Vittoria, Ramponi, Valentina, Scafetta, Giorgia, Moretti, Marta, Licursi, Valerio, Belardinilli, Francesca, Peruzzi, Giovanna, Infante, Paola, Goffredo, Bianca Maria, Coppa, Anna, Canettieri, Gianluca, Bartolazzi, Armando, Ponzoni, Mirco, Giannini, Giuseppe, Petroni, Marialaura

“…MYCN drives aggressive behavior and refractoriness to chemotherapy, in several tumors. Since MYCN inactivation in clinical settings is not achievable,…”
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CTNNB1 p.L31P mutation in an ovarian endometrioid carcinoma with synchronous uterine endometrioid carcinoma by Pecorella, Irene, Coppa, Anna, Nicolussi, Arianna, Manganaro, Lucia, Fiorentin, Francesco, Palaia, Innocenza, Muzii, Ludovico

“…[Display omitted] We performed next generation sequencing of DNA extracted from the neoplastic tissues obtained from a patient who underwent surgery for a…”
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A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma by Petroni, Marialaura, Fabretti, Francesca, Di Giulio, Stefano, Nicolis di Robilant, Vittoria, La Monica, Veronica, Moretti, Marta, Belardinilli, Francesca, Bufalieri, Francesca, Coppa, Anna, Paci, Paola, Corsi, Alessandro, De Smaele, Enrico, Coni, Sonia, Canettieri, Gianluca, Di Marcotullio, Lucia, Wang, Zhao‐Qi, Giannini, Giuseppe

“…Aims Inherited or somatic mutations in the MRE11, RAD50 and NBN genes increase the incidence of tumours, including medulloblastoma (MB). On the other hand,…”
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