Search Results - "Copley, Findlay"

CREBBP histone acetyltransferase domain mutations predict response to mTOR inhibition in relapsed/refractory follicular lymphoma by Kumar, Emil Arjun, Korfi, Koorosh, Bewicke‐Copley, Findlay, Close, Karina, Heward, James, Witzig, Thomas, Leukam, Michael, Ansell, Stephen, Scott, Jessica, Clear, Andrew, Efeyan, Alejo, Green, Michael, Siebert, Reiner, Peck, Barrie, Calaminici, Maria, Wang, Jun, Smith, Sonali, Novak, Anne, Fitzgibbon, Jude, Okosun, Jessica

“…Summary Despite the clinical and molecular heterogeneity of follicular lymphoma (FL), there remains a lack of biomarker‐directed therapeutic approaches in…”
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Germline ERCC excision repair 6 like 2 (ERCC6L2) mutations lead to impaired erythropoiesis and reshaping of the bone marrow microenvironment by Armes, Hannah, Bewicke‐Copley, Findlay, Rio‐Machin, Ana, Di Bella, Doriana, Philippe, Céline, Wozniak, Anna, Tummala, Hemanth, Wang, Jun, Ezponda, Teresa, Prosper, Felipe, Dokal, Inderjeet, Vulliamy, Tom, Kilpivaara, Outi, Wartiovaara‐Kautto, Ulla, Fitzgibbon, Jude, Rouault‐Pierre, Kevin

“…Summary Despite the inclusion of inherited myeloid malignancies as a separate entity in the World Health Organization Classification, many established…”
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A local regulatory network around three NAC transcription factors in stress responses and senescence in Arabidopsis leaves by Hickman, Richard, Hill, Claire, Penfold, Christopher A., Breeze, Emily, Bowden, Laura, Moore, Jonathan D., Zhang, Peijun, Jackson, Alison, Cooke, Emma, Bewicke‐Copley, Findlay, Mead, Andrew, Beynon, Jim, Wild, David L., Denby, Katherine J., Ott, Sascha, Buchanan‐Wollaston, Vicky

“…Summary A model is presented describing the gene regulatory network surrounding three similar NAC transcription factors that have roles in Arabidopsis leaf…”
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Extracellular vesicles released following heat stress induce bystander effect in unstressed populations by Bewicke-Copley, Findlay, Mulcahy, Laura Ann, Jacobs, Laura Ann, Samuel, Priya, Akbar, Naveed, Pink, Ryan Charles, Carter, David Raul Francisco

“…Cells naïve to stress can display the effects of stress, such as DNA damage and apoptosis, when they are exposed to signals from stressed cells; this…”
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Applications and analysis of targeted genomic sequencing in cancer studies by Bewicke-Copley, Findlay, Arjun Kumar, Emil, Palladino, Giuseppe, Korfi, Koorosh, Wang, Jun

“…Next Generation Sequencing (NGS) has dramatically improved the flexibility and outcomes of cancer research and clinical trials, providing highly sensitive and…”
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P1253: REDUCED EXPRESSION OF THE CHEMOKINES CXCL2, CXCL3 AND CXCL8 PROVIDES A POTENTIAL MECHANISM PROMOTING IMMUNE EVASION FACILITATING AML RELAPSE FOLLOWING ALLOGENEIC HSCT by Charrot, Sarah, Ball, Jennifer, Copley, Findlay, Aries, James, Mee, Matthew, Theocharidis, Symeon, Heward, James, Gribben, John, Davies, Jeff

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P1254: BASELINE HLA‐DR‐RESTRICTED NEOANTIGEN BURDEN OF AML BLASTS IMPACTS ON HLA‐DR GENE EXPRESSION AT RELAPSE AFTER ALLOGENEIC STEM CELL TRANSPLANT by Charrot, Sarah, Ball, Jennifer, Copley, Findlay, Aries, James, Mee, Matthew, Theocharidis, Symeon, Heward, James, Gribben, John, Davies, Jeff

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Acquired somatic variants in inherited myeloid malignancies by Armes, Hannah, Rio-Machin, Ana, Krizsán, Szilvia, Bödör, Csaba, Kaya, Fadimana, Bewicke-Copley, Findlay, Alnajar, Jenna, Walne, Amanda, Péterffy, Borbála, Tummala, Hemanth, Rouault-Pierre, Kevin, Dokal, Inderjeet, Vulliamy, Tom, Fitzgibbon, Jude

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The transcription factor DDIT3 is a potential driver of dyserythropoiesis in myelodysplastic syndromes by Berastegui, Nerea, Ainciburu, Marina, Romero, Juan P., Garcia-Olloqui, Paula, Alfonso-Pierola, Ana, Philippe, Céline, Vilas-Zornoza, Amaia, San Martin-Uriz, Patxi, Ruiz-Hernández, Raquel, Abarrategi, Ander, Ordoñez, Raquel, Alignani, Diego, Sarvide, Sarai, Castro-Labrador, Laura, Lamo-Espinosa, José M., San-Julian, Mikel, Jimenez, Tamara, López-Cadenas, Félix, Muntion, Sandra, Sanchez-Guijo, Fermin, Molero, Antonieta, Montoro, Maria Julia, Tazón, Bárbara, Serrano, Guillermo, Diaz-Mazkiaran, Aintzane, Hernaez, Mikel, Huerga, Sofía, Bewicke-Copley, Findlay, Rio-Machin, Ana, Maurano, Matthew T., Díez-Campelo, María, Valcarcel, David, Rouault-Pierre, Kevin, Lara-Astiaso, David, Ezponda, Teresa, Prosper, Felipe

“…Myelodysplastic syndromes (MDS) are hematopoietic stem cell (HSC) malignancies characterized by ineffective hematopoiesis, with increased incidence in older…”
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Targeting lysine demethylase 5 (KDM5) in mantle cell lymphoma by Xu, Danmei, Bewicke-Copley, Findlay, Close, Karina, Okosun, Jessica, Gale, Robert Peter, Apperley, Jane, Weinstock, David M., Wendel, Hans-Guido, Fitzgibbon, Jude

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Genetic heterogeneity highlighted by differential FDG-PET response in diffuse large B-cell lymphoma by Araf, Shamzah, Korfi, Koorosh, Bewicke-Copley, Findlay, Wang, Jun, Cogliatti, Sergio, Kumar, Emil, Forrer, Flavio, Barrington, Sally F, Graham, Trevor A, Scott, David W, Rimsza, Lisa M, Davies, Andrew, Johnson, Peter, Okosun, Jessica, Fitzgibbon, Jude, Fehr, Martin

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ACSNI: An unsupervised machine-learning tool for prediction of tissue-specific pathway components using gene expression profiles by Anene, Chinedu Anthony, Khan, Faraz, Bewicke-Copley, Findlay, Maniati, Eleni, Wang, Jun

“…Determining the tissue- and disease-specific circuit of biological pathways remains a fundamental goal of molecular biology. Many components of these…”
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Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes by Casado, Pedro, Rio-Machin, Ana, Miettinen, Juho J., Bewicke-Copley, Findlay, Rouault-Pierre, Kevin, Krizsan, Szilvia, Parsons, Alun, Rajeeve, Vinothini, Miraki-Moud, Farideh, Taussig, David C., Bödör, Csaba, Gribben, John, Heckman, Caroline, Fitzgibbon, Jude, Cutillas, Pedro R.

“…Acute myeloid leukaemia (AML) patients harbouring certain chromosome abnormalities have particularly adverse prognosis. For these patients, targeted therapies…”
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The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants by Rio-Machin, Ana, Vulliamy, Tom, Hug, Nele, Walne, Amanda, Tawana, Kiran, Cardoso, Shirleny, Ellison, Alicia, Pontikos, Nikolas, Wang, Jun, Tummala, Hemanth, Al Seraihi, Ahad Fahad H., Alnajar, Jenna, Bewicke-Copley, Findlay, Armes, Hannah, Barnett, Michael, Bloor, Adrian, Bödör, Csaba, Bowen, David, Fenaux, Pierre, Green, Andrew, Hallahan, Andrew, Hjorth-Hansen, Henrik, Hossain, Upal, Killick, Sally, Lawson, Sarah, Layton, Mark, Male, Alison M., Marsh, Judith, Mehta, Priyanka, Mous, Rogier, Nomdedéu, Josep F., Owen, Carolyn, Pavlu, Jiri, Payne, Elspeth M., Protheroe, Rachel E., Preudhomme, Claude, Pujol-Moix, Nuria, Renneville, Aline, Russell, Nigel, Saggar, Anand, Sciuccati, Gabriela, Taussig, David, Toze, Cynthia L., Uyttebroeck, Anne, Vandenberghe, Peter, Schlegelberger, Brigitte, Ripperger, Tim, Steinemann, Doris, Wu, John, Mason, Joanne, Page, Paula, Akiki, Susanna, Reay, Kim, Cavenagh, Jamie D., Plagnol, Vincent, Caceres, Javier F., Fitzgibbon, Jude, Dokal, Inderjeet

“…The inclusion of familial myeloid malignancies as a separate disease entity in the revised WHO classification has renewed efforts to improve the recognition…”
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Meta-analysis using a novel database, miRStress, reveals miRNAs that are frequently associated with the radiation and hypoxia stress-responses by Jacobs, Laura Ann, Bewicke-Copley, Findlay, Poolman, Mark Graham, Pink, Ryan Charles, Mulcahy, Laura Ann, Baker, Isabel, Beaman, Ellie-May, Brooks, Travis, Caley, Daniel Paul, Cowling, William, Currie, James Michael Stevenson, Horsburgh, Jessica, Kenehan, Lottie, Keyes, Emma, Leite, Daniel, Massa, Davide, McDermott-Rouse, Adam, Samuel, Priya, Wood, Hannah, Kadhim, Munira, Carter, David Raul Francisco

“…Organisms are often exposed to environmental pressures that affect homeostasis, so it is important to understand the biological basis of stress-response…”
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Characterising Tumour and Microenvironmental Responses to R-CHOP in Immunocompetent Mouse Models of DLBCL by Maybury, Bernard D, Bewicke-Copley, Findlay, Johnson, Peter, Fitzgibbon, Jude, Calado, Dinis Pedro

“…R-CHOP chemoimmunotherapy has been the standard of care for diffuse large B cell lymphoma (DLBCL) for 20 years. The lymphoma and microenvironment responses to…”
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The Genomic Landscape of Actinic Keratosis by Thomson, Jason, Bewicke-Copley, Findlay, Anene, Chinedu Anthony, Gulati, Abha, Nagano, Ai, Purdie, Karin, Inman, Gareth J., Proby, Charlotte M., Leigh, Irene M., Harwood, Catherine A., Wang, Jun

“…Actinic keratoses (AKs) are lesions of epidermal keratinocyte dysplasia and are precursors for invasive cutaneous squamous cell carcinoma (cSCC). Identifying…”
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KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas by Heward, James, Koniali, Lola, D'Avola, Annalisa, Close, Karina, Yeomans, Alison, Philpott, Martin, Dunford, James, Rahim, Tahrima, Al Seraihi, Ahad F., Wang, Jun, Korfi, Koorosh, Araf, Shamzah, Iqbal, Sameena, Bewicke-Copley, Findlay, Kumar, Emil, Barisic, Darko, Calaminici, Maria, Clear, Andrew, Gribben, John, Johnson, Peter, Neve, Richard, Cutillas, Pedro, Okosun, Jessica, Oppermann, Udo, Melnick, Ari, Packham, Graham, Fitzgibbon, Jude

“…Loss-of-function mutations in KMT2D are a striking feature of germinal center (GC) lymphomas, resulting in decreased histone 3 lysine 4 (H3K4) methylation and…”
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Defining an Optimized Workflow for Enriching and Analyzing Residual Tumor Populations Using Intracellular Markers by Coulter, Eve M., Bewicke-Copley, Findlay, Mossner, Maximilian, Graham, Trevor A., Fitzgibbon, Jude, Okosun, Jessica

“…Tumor relapse is well recognized to arise from treatment-resistant residual populations. Strategies enriching such populations for in-depth downstream analyses…”
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The Paradoxical Efficacy of KDM6 Inhibition in Germinal Centre B-Cell Lymphomas by Close, Karina, Armes, Hannah, Kumar, Emil, Bewicke-Copley, Findlay, Cribbs, Adam, Dunford, James, Philpott, Martin, Oppermann, Udo, Heward, James, Fitzgibbon, Jude

“…Introduction Germinal centre (GC) lymphomas Follicular Lymphoma (FL) and Diffuse Large B Cell Lymphoma (DLBCL) are strikingly dependent on mutations affecting…”
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