Search Results - "Coplan, Jeremy"

Necessity of hippocampal neurogenesis for the therapeutic action of antidepressants in adult nonhuman primates by Perera, Tarique D, Dwork, Andrew J, Keegan, Kathryn A, Thirumangalakudi, Lakshmi, Lipira, Cecilia M, Joyce, Niamh, Lange, Christopher, Higley, J Dee, Rosoklija, Gorazd, Hen, Rene, Sackeim, Harold A, Coplan, Jeremy D

“…Rodent studies show that neurogenesis is necessary for mediating the salutary effects of antidepressants. Nonhuman primate (NHP) studies may bridge important…”
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The Nucleus Accumbens and Ketamine Treatment in Major Depressive Disorder by Abdallah, Chadi G, Jackowski, Andrea, Salas, Ramiro, Gupta, Swapnil, Sato, João R, Mao, Xiangling, Coplan, Jeremy D, Shungu, Dikoma C, Mathew, Sanjay J

“…Animal models of depression repeatedly showed stress-induced nucleus accumbens (NAc) hypertrophy. Recently, ketamine was found to normalize this stress-induced…”
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Psychosocial Intervention Improves Depression, Quality of Life, and Fluid Adherence in Hemodialysis by CUKOR, Daniel, VER HALEN, Nisha, ROSENTHAL ASHER, Deborah, COPLAN, Jeremy D, WEEDON, Jeremy, WYKA, Katarzyna E, SAGGI, Subodh J, KIMMEL, Paul L

“…Patients with ESRD have high rates of depression, which is associated with diminished quality of life and survival. We determined whether individual cognitive…”
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Treating comorbid anxiety and depression: Psychosocial and pharmacological approaches by Coplan, Jeremy D, Aaronson, Cindy J, Panthangi, Venkatesh, Kim, Younsuk

“…Comorbid anxiety with depression predicts poor outcomes with a higher percentage of treatment resistance than either disorder occurring alone. Overlap of…”
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37.4 NONHUMAN PRIMATE MODELS OF EARLY LIFE STRESS: RELEVANCE TO CHILDHOOD MOOD DISORDERS, SSRI TREATMENT RESISTANCE, AND SUICIDE by Coplan, Jeremy, MD

“…Objectives: Early life stress (ELS) alters serotonin neurotransmission, implicated in many psychiatric disorders. Childhood depression is characterized by…”
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A neurobiological hypothesis of treatment-resistant depression - mechanisms for selective serotonin reuptake inhibitor non-efficacy by Coplan, Jeremy D, Gopinath, Srinath, Abdallah, Chadi G, Berry, Benjamin R

“…First-line treatment of major depression includes administration of a selective serotonin reuptake inhibitor (SSRI), yet studies suggest that remission rates…”
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The Research Domain Criteria (RDoC) Project and Studies of Risk and Resilience in Maltreated Children by Kaufman, Joan, PhD, Gelernter, Joel, MD, Hudziak, James J., MD, Tyrka, Audrey R., MD, PhD, Coplan, Jeremy D., MD

“…Objective The Research Domain Criteria (RDoC) project was initiated to develop, for research purposes, new ways of classifying mental disorders based on…”
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Antidepressant-Induced Neurogenesis in the Hippocampus of Adult Nonhuman Primates by Perera, Tarique D, Coplan, Jeremy D, Lisanby, Sarah H, Lipira, Cecilia M, Arif, Mohamed, Carpio, Cristina, Spitzer, Gila, Santarelli, Luca, Scharf, Bruce, Hen, Rene, Rosoklija, Gorazd, Sackeim, Harold A, Dwork, Andrew J

“…New neurons are generated in the adult hippocampus of many species including rodents, monkeys, and humans. Conditions associated with major depression, such as…”
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Maturational phase of hippocampal neurogenesis and cognitive flexibility by Webler, Ryan D., Fulton, Sasha, Perera, Tarique D., Coplan, Jeremy D.

“…•Number of immature new DG neurons predicts CA3 activity during a cognitive flexibility task.•Higher number of immature new DG neurons and lower CA3 activity…”
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Maternal hypothalamic-pituitary-adrenal axis response to foraging uncertainty: A model of individual vs. social allostasis and the "Superorganism Hypothesis" by Coplan, Jeremy D, Gupta, Nishant K, Karim, Asif, Rozenboym, Anna, Smith, Eric L P, Kral, John G, Rosenblum, Leonard A

“…Food insecurity is a major global contributor to developmental origins of adult disease. The allostatic load of maternal food uncertainty from variable…”
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Lifelong reductions of PKMζ in ventral hippocampus of nonhuman primates exposed to early-life adversity due to unpredictable maternal care by Fulton, Sasha L, Hsieh, Changchi, Atkin, Tobias, Norris, Ryan, Schoenfeld, Eric, Tsokas, Panayiotis, Fenton, André Antonio, Sacktor, Todd Charlton, Coplan, Jeremy D

“…Protein kinase Mζ (PKMζ) maintains long-term potentiation (LTP) and long-term memory through persistent increases in kinase expression. Early-life adversity is…”
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Early Life Stress and the Fate of Kynurenine Pathway Metabolites by Coplan, Jeremy D, George, Roza, Syed, Shariful A, Rozenboym, Annalam V, Tang, Jean E, Fulton, Sasha L, Perera, Tarique D

“…Early life stress (ELS) precedes alterations to neuro-immune activation, which may mediate an increased risk for stress-related psychiatric disorders,…”
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Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder by Abdallah, Chadi G, Jackowski, Andrea, Sato, João R, Mao, Xiangling, Kang, Guoxin, Cheema, Raminder, Coplan, Jeremy D, Mathew, Sanjay J, Shungu, Dikoma C

“…Abstract Hippocampal volume reduction has been related to treatment-resistant depression (TRD) and is hypothesized to reflect impaired amino-acid…”
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DNA methylation as a risk factor in the effects of early life stress by Kinnally, Erin L, Feinberg, Caroline, Kim, David, Ferguson, Kerel, Leibel, Rudolph, Coplan, Jeremy D, John Mann, J

“…Highlight ► Whole genome and candidate gene (serotonin transporter) blood DNA methylation is associated with enhanced stress reactivity in adult macaques that…”
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Depression and Anxiety in Urban Hemodialysis Patients by Cukor, Daniel, Coplan, Jeremy, Brown, Clinton, Friedman, Steven, Cromwell-Smith, Allyson, Peterson, Rolf A, Kimmel, Paul L

“…Depression is well established as a prevalent mental health problem for people with ESRD and is associated with morbidity and mortality. However, depression in…”
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Neurobiology of the dorsolateral prefrontal cortex in GAD: Aberrant neurometabolic correlation to hippocampus and relationship to anxiety sensitivity and IQ by Coplan, Jeremy D., Webler, Ryan, Gopinath, Srinath, Abdallah, Chadi G., Mathew, Sanjay J.

“…The neurometabolism underlying the cognitive and affective symptoms associated with generalized anxiety disorder (GAD) remain poorly understood. After we have…”
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Developmental Antecedents of Adult Macaque Neurogenesis: Early-Life Adversity, 5-HTTLPR Polymorphisms, and Adolescent Hippocampal Volume by Schoenfeld, Eric M., Gupta, Nishant K., Syed, Shariful A., Rozenboym, Anna V., Fulton, Sasha L., Jackowski, Andrea P., Perera, Tarique D., Coplan, Jeremy D.

“…•Early-life adversity and short 5-HTTLPR allele concertedly attenuate neurogenesis•Normalized adolescent hippocampal volume predicts ipsilateral adult…”
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Risk and Resilience: Early Manipulation of Macaque Social Experience and Persistent Behavioral and Neurophysiological Outcomes by Stevens, Hanna E., M.D., Ph.D, Leckman, James F., M.D, Coplan, Jeremy D., M.D, Suomi, Stephen J., Ph.D

“…Abstract Objective To review the contributions of research on nonhuman primates, specifically macaque monkeys, to the understanding of early social stress and…”
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The ALPIM (Anxiety, Laxity, Pain, Immune, and Mood) Syndrome in Adolescents and Young Adults: A Cohort Study by Singh, Deepan, Rocio Martinez, Wendy, Anand, Niyati, Pinkhasov, Aaron, Calixte, Rose, Bulbena, Antonio, Coplan, Jeremy D

“…Objective:ALPIM (anxiety, laxity, pain, immune, and mood) syndrome has been previously described in adults. The authors aimed to identify its occurrence in…”
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Early-Life Stress and the Development of Obesity and Insulin Resistance in Juvenile Bonnet Macaques by KAUFMAN, Daniel, BANERJI, Mary Ann, SHORMAN, Igor, SMITH, Eric L. P, COPLAN, Jeremy D, ROSENBLUM, Leonard A, KRAL, John G

“…Early-Life Stress and the Development of Obesity and Insulin Resistance in Juvenile Bonnet Macaques Daniel Kaufman 1 2 , Mary Ann Banerji 2 3 , Igor Shorman 1…”
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