Search Results - "Copello, Julio A."

Ryanodine Receptor Calcium Release Channels by Fill, Michael, Copello, Julio A

“…Department of Physiology, Loyola University Chicago, Maywood, Illinois Fill, Michael and Julio A. Copello. Ryanodine Receptor Calcium Release Channels…”
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Single Ryanodine Receptor Channel Basis of Caffeine's Action on Ca²⁺ Sparks by Porta, Maura, Zima, Aleksey V, Nani, Alma, Diaz-Sylvester, Paula L, Copello, Julio A, Ramos-Franco, Josefina, Blatter, Lothar A, Fill, Michael

“…Caffeine (1, 3, 7-trimethylxanthine) is a widely used pharmacological agonist of the cardiac ryanodine receptor (RyR2) Ca²⁺ release channel. It is also a…”
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CGP-37157 inhibits the sarcoplasmic reticulum Ca²+ ATPase and activates ryanodine receptor channels in striated muscle by Neumann, Jake T, Diaz-Sylvester, Paula L, Fleischer, Sidney, Copello, Julio A

“…7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one [CGP-37157 (CGP)], a benzothiazepine derivative of clonazepam, is commonly used as a…”
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Removal of FKBP12.6 Does Not Alter the Conductance and Activation of the Cardiac Ryanodine Receptor or the Susceptibility to Stress-induced Ventricular Arrhythmias by Xiao, Jianmin, Tian, Xixi, Jones, Peter P., Bolstad, Jeff, Kong, Huihui, Wang, Ruiwu, Zhang, Lin, Duff, Henry J., Gillis, Anne M., Fleischer, Sidney, Kotlikoff, Michael, Copello, Julio A., Chen, S. R. Wayne

“…The 12.6-kDa FK506-binding protein (FKBP12.6) is considered to be a key regulator of the cardiac ryanodine receptor (RyR2), but its precise role in RyR2…”
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Coupled gating of skeletal muscle ryanodine receptors is modulated by Ca2+, Mg2+, and ATP by Porta, Maura, Diaz-Sylvester, Paula L, Neumann, Jake T, Escobar, Ariel L, Fleischer, Sidney, Copello, Julio A

“…Coupled gating (synchronous openings and closures) of groups of skeletal muscle ryanodine receptors (RyR1), which mimics RyR1-mediated Ca(2+) release…”
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Modulation of cardiac ryanodine receptor channels by alkaline earth cations by Diaz-Sylvester, Paula L, Porta, Maura, Copello, Julio A

“…Cardiac ryanodine receptor (RyR2) function is modulated by Ca(2+) and Mg(2+). To better characterize Ca(2+) and Mg(2+) binding sites involved in RyR2…”
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TRIC‐A channels rock out alone while TRIC‐B get high with a little help from their friends by Copello, Julio A.

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Halothane modulation of skeletal muscle ryanodine receptors: dependence on Ca2+, Mg2+, and ATP by Diaz-Sylvester, Paula L, Porta, Maura, Copello, Julio A

“…Malignant hyperthermia (MH) susceptibility is a genetic disorder of skeletal muscle associated with mutations in the ryanodine receptor isoform 1 (RyR1) of…”
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Thermal modulation of epicardial Ca2+ dynamics uncovers molecular mechanisms of Ca2+ alternans by Millet, Jose, Aguilar-Sanchez, Yuriana, Kornyeyev, Dmytro, Bazmi, Maedeh, Fainstein, Diego, Copello, Julio A, Escobar, Ariel L

“…Ca2+ alternans (Ca-Alts) are alternating beat-to-beat changes in the amplitude of Ca2+ transients that frequently occur during tachycardia, ischemia, or…”
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Voltage-dependent modulation of cardiac ryanodine receptors (RyR2) by protamine by Diaz-Sylvester, Paula L, Copello, Julio A

“…It has been reported that protamine (>10 microg/ml) blocks single skeletal RyR1 channels and inhibits RyR1-mediated Ca2+ release from sarcoplasmic reticulum…”
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Correction: Thermal modulation of epicardial Ca2+ dynamics uncovers molecular mechanisms of Ca2+ alternans by Millet, Jose, Aguilar-Sanchez, Yuriana, Kornyeyev, Dmytro, Bazmi, Maedeh, Fainstein, Diego, Copello, Julio A, Escobar, Ariel L

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K201 (JTV519) is a Ca2+-Dependent Blocker of SERCA and a Partial Agonist of Ryanodine Receptors in Striated Muscle by Darcy, Yuanzhao L, Diaz-Sylvester, Paula L, Copello, Julio A

“…K201 (JTV-519) may prevent abnormal Ca(2+) leak from the sarcoplasmic reticulum (SR) in the ischemic heart and skeletal muscle (SkM) by stabilizing the…”
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Differential modulation of cardiac and skeletal muscle ryanodine receptors by NADH by Zima, Aleksey V, Copello, Julio A, Blatter, Lothar A

“…The effects of nicotinamide-adenine dinucleotides (NADH, NAD +, NADPH) on ryanodine receptor channels (RyRs) from cardiac and skeletal muscle were compared in…”
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A biochemical characterization of the major peptides from the Venom of the giant Neotropical hunting ant Dinoponera australis by Johnson, Stephen R., Copello, Julio A., Evans, M. Steven, Suarez, Andrew V.

“…Venom from the “false tocandira” Dinoponera australis, a giant Neotropical hunting ant, paralyzes small invertebrate prey and induces a myriad of systemic…”
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Cross-reactivity of ryanodine receptors with plasma membrane ion channel modulators by Neumann, Jake T, Copello, Julio A

“…Various pharmacological agents designed to modulate plasma membrane ion channels seem to significantly affect intracellular Ca²⁺ signaling when acting on their…”
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Eudistomin D and penaresin derivatives as modulators of ryanodine receptor channels and sarcoplasmic reticulum Ca2+ ATPase in striated muscle by Diaz-Sylvester, Paula L, Porta, Maura, Juettner, Vanessa V, Lv, Yuanzhao, Fleischer, Sidney, Copello, Julio A

“…Eudistomin D (EuD) and penaresin (Pen) derivatives are bioactive alkaloids from marine sponges found to induce Ca(2+) release from striated muscle sarcoplasmic…”
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Effects of cytosolic NADH/NAD(+) levels on sarcoplasmic reticulum Ca(2+) release in permeabilized rat ventricular myocytes by Zima, Aleksey V, Copello, Julio A, Blatter, Lothar A

“…In the heart ischaemic conditions induce metabolic changes known to have profound effects on Ca(2+) signalling during excitation-contraction coupling…”
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Effects of cytosolic NADH/NAD+ levels on sarcoplasmic reticulum Ca2+ release in permeabilized rat ventricular myocytes by Zima, Aleksey V., Copello, Julio A., Blatter, Lothar A.

“…In the heart ischaemic conditions induce metabolic changes known to have profound effects on Ca 2+ signalling during excitation–contraction coupling…”
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Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy by Kotlikoff, Michael I, Fleischer, Sidney, Xin, Hong-Bo, Senbonmatsu, Takaaki, Cheng, Dong-Sheng, Wang, Yong-Xiao, Copello, Julio A, Ji, Guang-Ju, Collier, Mei Lin, Deng, Ke-Yu, Jeyakumar, Loice H, Magnuson, Mark A, Inagami, Tadashi

“…FK506 binding proteins 12 and 12.6 (FKBP12 and FKBP12.6) are intracellular receptors for the immunosuppressant drug FK506 (ref. 1). The skeletal muscle…”
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Ryanodol action on calcium sparks in ventricular myocytes by Ramos-Franco, Josefina, Gomez, Ana M., Nani, Alma, Liu, Yiwei, Copello, Julio A., Fill, Michael

“…The action of ryanodol on single cardiac ryanodine receptor (RyR2) channels in bilayers and local RyR2-mediated Ca 2+ release events (Ca 2+ sparks) in…”
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