Search Results - "Cooray, Sadani N."

Ligand-specific conformational change of the G-protein–coupled receptor ALX/FPR2 determines proresolving functional responses by Cooray, Sadani N., Gobbetti, Thomas, Montero-Melendez, Trinidad, McArthur, Simon, Thompson, Dawn, Clark, Adrian J. L., Flower, Roderick J., Perretti, Mauro

“…Formyl-peptide receptor type 2 (FPR2), also called ALX (the lipoxin A4 receptor), conveys the proresolving properties of lipoxin A ₄ and annexin A1 (AnxA1) and…”
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MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family by Chan, Li F, Webb, Tom R, Chung, Teng-Teng, Meimaridou, Eirini, Cooray, Sadani N, Guasti, Leonardo, Chapple, J. Paul, Egertová, Michaela, Elphick, Maurice R, Cheetham, Michael E, Metherell, Louise A, Clark, Adrian J.L

“…The melanocortin receptor (MCR) family consists of 5 G protein-coupled receptors (MC1R-MC5R) with diverse physiologic roles. MC2R is a critical component of…”
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The E3 Ubiquitin Ligase Mahogunin Ubiquitinates the Melanocortin 2 Receptor by Cooray, Sadani N, Guasti, Leonardo, Clark, Adrian J. L

“…Mahogunin ring fnger-1(MGRN1) encodes an E3 ubiquitin ligase and is mutated in the mahoganoid mouse. The mahoganoid mouse mutant shows similarities to the…”
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Distinct Melanocortin 2 Receptor Accessory Protein Domains Are Required for Melanocortin 2 Receptor Interaction and Promotion of Receptor Trafficking by Webb, Tom R, Chan, Li, Cooray, Sadani N, Cheetham, Michael E, Chapple, J. Paul, Clark, Adrian J. L

“…Melanocortin 2 receptor (MC2R) is the receptor for the pituitary hormone ACTH. When activated, MC2R stimulates cAMP production and adrenal steroidogenesis. The…”
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Annexin A1 and resolution of inflammation: tissue repairing properties and signalling signature by Gobbetti, Thomas, Cooray, Sadani N

“…Inflammation is essential to protect the host from exogenous and endogenous dangers that ultimately lead to tissue injury. The consequent tissue repair is…”
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Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects by Montero-Melendez, Trinidad, Gobbetti, Thomas, Cooray, Sadani N, Jonassen, Thomas E N, Perretti, Mauro

“…There is a need for novel approaches to control pathologies with overexuberant inflammatory reactions. Targeting melanocortin (MC) receptors represents a…”
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Melanocortin receptors and their accessory proteins by Cooray, Sadani N., Clark, Adrian J.L.

“…The melanocortin receptor family consists of 5 members which belong to the GPCR superfamily. Their specific ligands, the melanocortins are peptide hormones…”
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Bioluminescence Resonance Energy Transfer Reveals the Adrenocorticotropin (ACTH)-Induced Conformational Change of the Activated ACTH Receptor Complex in Living Cells by Cooray, Sadani N, Chung, Teng-Teng, Mazhar, Khansa, Szidonya, Laszlo, Clark, Adrian J. L

“…Bioluminescence resonance energy transfer analysis is used to study the interaction between melanocortin 2 receptor (MC2R) accessory protein and the MC2R and…”
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The Melanocortin 2 Receptor Accessory Protein Exists as a Homodimer and Is Essential for the Function of the Melanocortin 2 Receptor in the Mouse Y1 Cell Line by Cooray, Sadani N, Almiro Do Vale, Isabel, Leung, Kit-Yi, Webb, Tom R, Chapple, J. Paul, Egertová, Michaela, Cheetham, Michael E, Elphick, Maurice R, Clark, Adrian J. L

“…The ACTH receptor [melanocortin 2 receptor (MC2R)] gene produces a functional receptor only when transfected into cells of adrenocortical origin, implying that…”
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Accessory proteins are vital for the functional expression of certain G protein-coupled receptors by Cooray, Sadani N., Chan, Li, Webb, Tom R., Metherell, Louise, Clark, Adrian J.L.

“…Certain G protein-coupled receptors (GPCRs) fail to be expressed in a functional form at the cell surface. This may be due to the improper folding and…”
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Adrenocorticotropin resistance syndromes by Cooray, Sadani N, Chan, Li, Metherell, Lou, Storr, Helen, Clark, Adrian J L

“…Familial glucocorticoid deficiency (FGD) and triple A syndrome belong to a rare group of autosomal recessive disorders characterized by adrenocorticotropin…”
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Distinct MRAP domains are required for MC2R interaction and promotion of receptor trafficking by Webb, Tom R., Chan, Li, Cooray, Sadani N., Cheetham, Michael E., Chapple, J. Paul, Clark, Adrian J. L.

“…Melanocortin 2 receptor (MC2R) is the receptor for the pituitary hormone adrenocorticotropin (ACTH). When activated, MC2R stimulates cAMP production and…”
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