Search Results - "Cooper‐DeHoff, Rhonda M."

Medication Adherence-Still the Holy Grail by Cooper-DeHoff, Rhonda M, Smith, Steven M

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Clinical pharmacogenetics implementation: Approaches, successes, and challenges by Weitzel, Kristin W., Elsey, Amanda R., Langaee, Taimour Y., Burkley, Benjamin, Nessl, David R., Obeng, Aniwaa Owusu, Staley, Benjamin J., Dong, Hui-Jia, Allan, Robert W., Liu, J. Felix, Cooper-DeHoff, Rhonda M., Anderson, R. David, Conlon, Michael, Clare-Salzler, Michael J., Nelson, David R., Johnson, Julie A.

“…Current challenges exist to widespread clinical implementation of genomic medicine and pharmacogenetics. The University of Florida (UF) Health Personalized…”
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Optimizing identification of resistant hypertension: Computable phenotype development and validation by McDonough, Caitrin W., Babcock, Kyle, Chucri, Kristen, Crawford, Dana C., Bian, Jiang, Modave, François, Cooper‐DeHoff, Rhonda M., Hogan, William R.

“…Purpose Computable phenotypes are constructed to utilize data within the electronic health record (EHR) to identify patients with specific characteristics; a…”
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β2‐Adrenergic Receptor Gene Affects the Heart Rate Response of β‐Blockers: Evidence From 3 Clinical Studies by Shahin, Mohamed H., Rouby, Nihal El, Conrado, Daniela J., Gonzalez, Daniel, Gong, Yan, Lobmeyer, Maximilian T., Beitelshees, Amber L., Boerwinkle, Eric, Gums, John G., Chapman, Arlene, Turner, Stephen T., Pepine, Carl J., Cooper‐DeHoff, Rhonda M., Johnson, Julie A.

“…β‐Blockers’ heart rate (HR)‐lowering effect is an important determinant of the effectiveness for this class of drugs, yet it is variable among…”
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PCSK9 Inhibitor Use in the Real World: Data From the National Patient-Centered Research Network by Chamberlain, Alanna M, Gong, Yan, Shaw, Kathryn McAuliffe, Bian, Jiang, Song, Wen-Liang, Linton, MacRae F, Fonseca, Vivian, Price-Haywood, Eboni, Guhl, Emily, King, Jordan B, Shah, Rashmee U, Puro, Jon, Shenkman, Elizabeth, Pawloski, Pamala A, Margolis, Karen L, Hernandez, Adrian F, Cooper-DeHoff, Rhonda M

“…Background PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors effectively lower LDL (low-density lipoprotein) cholesterol and have been shown to…”
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Circulating microRNA Biomarkers of Thiazide Response in Hypertension by Chekka, Lakshmi Manasa S, Tantawy, Marwa, Langaee, Taimour, Wang, Danxin, Renne, Rolf, Chapman, Arlene B, Gums, John G, Boerwinkle, Eric, Cooper-DeHoff, Rhonda M, Johnson, Julie A

“…Thiazide diuretics are the second most frequently prescribed class of antihypertensives, but up to 50% of patients with hypertension have minimal…”
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Racial and Ethnic Differences in Cardiac Surveillance Evaluation of Patients Treated With Anthracycline-Based Chemotherapy by DeRemer, David L, Nguyen, Nam K, Guha, Avirup, Ahmad, Faraz S, Cooper-DeHoff, Rhonda M, Pepine, Carl J, Fradley, Michael G, Gong, Yan

“…Background Anthracyclines remain a key treatment for many malignancies but can increase the risk of heart failure or cardiomyopathy. Specific guidelines…”
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Blood Pressure and Outcomes in Very Old Hypertensive Coronary Artery Disease Patients: An INVEST Substudy by Denardo, Scott J., MD, Gong, Yan, PhD, Nichols, Wilmer W., PhD, Messerli, Franz H., MD, Bavry, Anthony A., MD, MPH, Cooper-DeHoff, Rhonda M., PharmD, Handberg, Eileen M., PhD, Champion, Annette, MBA, Pepine, Carl J., MD

“…Abstract Background Our understanding of the growing population of very old patients (aged ≥80 years) with coronary artery disease and hypertension is limited,…”
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Integrated metabolomics analysis reveals mechanistic insights into variability in blood pressure response to thiazide diuretics and beta blockers by Mehanna, Mai, McDonough, Caitrin W., Smith, Steven M., Gong, Yan, Gums, John G., Chapman, Arlene B., Johnson, Julie A., Cooper‐DeHoff, Rhonda M.

“…Hypertensive patients with a higher proportion of genetic West African ancestry (%GWAA) have better blood pressure (BP) response to thiazide diuretics (TDs)…”
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Initial Antihypertensive Regimens in Newly Treated Patients: Real World Evidence From the OneFlorida+ Clinical Research Network by Smith, Steven M, Winterstein, Almut G, Gurka, Matthew J, Walsh, Marta G, Keshwani, Shailina, Libby, Anne M, Hogan, William R, Pepine, Carl J, Cooper-DeHoff, Rhonda M

“…Background Knowledge of real-world antihypertensive use is limited to prevalent hypertension, limiting our understanding of how treatment evolves and its…”
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Improvement in Blood Pressure Control in Safety Net Clinics Receiving 2 Versions of a Scalable Quality Improvement Intervention: BP MAP A Pragmatic Cluster Randomized Trial by Fontil, Valy, Modrow, Madelaine Faulkner, Cooper-DeHoff, Rhonda M, Wozniak, Gregory, Rakotz, Michael, Todd, Jonathan, Azar, Kristen, Murakami, Linda, Sanders, Margaret, Chamberlain, Alanna M, O'Brien, Emily, Lee, April, Carton, Thomas, Pletcher, Mark J

“…Background Uncontrolled blood pressure (BP) remains a leading cause of death in the United States. The American Medical Association developed a quality…”
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Pairwise comparison of hydrochlorothiazide and chlorthalidone responses among hypertensive patients by Chekka, Lakshmi Manasa S., Cooper‐DeHoff, Rhonda M., Gums, John G., Chapman, Arlene B., Johnson, Julie A.

“…This study conducted a pairwise comparison of antihypertensive and metabolic effects of hydrochlorothiazide (HCTZ) and chlorthalidone (CTD) at 25 mg/day in the…”
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Tracking Blood Pressure Control Performance and Process Metrics in 25 US Health Systems: The PCORnet Blood Pressure Control Laboratory by Cooper-DeHoff, Rhonda M, Fontil, Valy, Carton, Thomas, Chamberlain, Alanna M, Todd, Jonathan, O'Brien, Emily C, Shaw, Kathryn M, Smith, Myra, Choi, Sujung, Nilles, Ester K, Ford, Daniel, Tecson, Kristen M, Dennar, Princess E, Ahmad, Faraz, Wu, Shenghui, McClay, James C, Azar, Kristen, Singh, Rajbir, Faulkner Modrow, Madelaine, Shay, Christina M, Rakotz, Michael, Wozniak, Gregory, Pletcher, Mark J

“…Background The National Patient-Centered Clinical Research Network Blood Pressure Control Laboratory Surveillance System was established to identify…”
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Implementation of a pharmacogenetic panel‐based test for pharmacotherapy‐based supportive care in an adult oncology clinic by Cicali, Emily J., Eddy, Elizabeth, Gong, Yan, Elchynski, Amanda L., Pena del Aguila, Kim, Basha, Tala, Daily, Karen C., Dickson, Lauren, Fischer, Steven, Hastings‐Monari, Erin, Jones, Dennie, Ramnaraign, Brian H., DeRemer, David L., George, Thomas J., Cooper‐DeHoff, Rhonda M.

“…The University of Florida Health conducted a pragmatic implementation of a pharmacogenetics (PGx) panel‐based test to guide medications used for supportive…”
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The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin‐Associated Musculoskeletal Symptoms by Cooper‐DeHoff, Rhonda M., Niemi, Mikko, Ramsey, Laura B., Luzum, Jasmine A., Tarkiainen, E. Katriina, Straka, Robert J., Gong, Li, Tuteja, Sony, Wilke, Russell A., Wadelius, Mia, Larson, Eric A., Roden, Dan M., Klein, Teri E., Yee, Sook Wah, Krauss, Ronald M., Turner, Richard M., Palaniappan, Latha, Gaedigk, Andrea, Giacomini, Kathleen M., Caudle, Kelly E., Voora, Deepak

“…Statins reduce cholesterol, prevent cardiovascular disease, and are among the most commonly prescribed medications in the world. Statin‐associated…”
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Pharmacogenomics of antihypertensive drugs: Rationale and design of the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) study by Johnson, Julie A., PharmD, Boerwinkle, Eric, PhD, Zineh, Issam, PharmD, Chapman, Arlene B., MD, Bailey, Kent, PhD, Cooper-DeHoff, Rhonda M., PharmD, MS, Gums, John, PharmD, Curry, R. Whit, MD, Gong, Yan, PhD, Beitelshees, Amber L., PharmD, MPH, Schwartz, Gary, MD, Turner, Stephen T., MD

“…Background Selection of antihypertensive therapy is often empiric, and use of genetic information to guide drug therapy selection holds future promise. Trial…”
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Genome-Wide Meta-Analysis of Blood Pressure Response to β1-Blockers: Results From ICAPS (International Consortium of Antihypertensive Pharmacogenomics Studies) by Singh, Sonal, Warren, Helen R, Hiltunen, Timo P, McDonough, Caitrin W, El Rouby, Nihal, Salvi, Erika, Wang, Zhiying, Garofalidou, Tatiana, Fyhrquist, Frej, Kontula, Kimmo K, Glorioso, Valeria, Zaninello, Roberta, Glorioso, Nicola, Pepine, Carl J, Munroe, Patricia B, Turner, Stephan T, Chapman, Arlene B, Boerwinkle, Eric, Johnson, Julie A, Gong, Yan, Cooper-DeHoff, Rhonda M

“…BackgroundThere exists a wide interindividual variability in blood pressure (BP) response to β1‐blockers. To identify the genetic determinants of this…”
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Aldosterone inhibition and coronary endothelial function in women without obstructive coronary artery disease: An ancillary study of the National Heart, Lung, and Blood Institute–sponsored Women's Ischemia Syndrome Evaluation by Bavry, Anthony A., MD, Handberg, Eileen M., PhD, Huo, Tianyao, PhD, Lerman, Amir, MD, Quyyumi, Arshed A., MD, Shufelt, Chrisandra, MD, Sharaf, Barry, MD, Merz, C. Noel Bairey, MD, Cooper-DeHoff, Rhonda M., PharmD, Sopko, George, MD, Pepine, Carl J., MD

“…Background Endothelial dysfunction is highly prevalent and associated with adverse outcomes among patients without obstructive coronary artery disease (CAD)…”
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Atherosclerotic cardiovascular disease risk assessment and predictors of statin use in Filipino‐American Women by Borja‐Hart, Nancy, Graff, J. Carolyn, Nolan, Vikki G., Wang, Jiajing, Cooper‐DeHoff, Rhonda M., Ancheta, Irma B.

“…Summary What is known and objective Race and gender disparities in the context of appropriate treatment with lipid‐lowering therapies do exist. The 2013…”
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Optimizing Precision of Hypertension Care to Maximize Blood Pressure Control: A Pilot Study Utilizing a Smartphone App to Incorporate Plasma Renin Activity Testing by Mehanna, Mai, Chen, Yiqing E., Gong, Yan, Handberg, Eileen, Roth, Brittney, De Leon, Jessica, Smith, Steven M., Harrell, Jonathan G., Cooper‐DeHoff, Rhonda M.

“…Only half of patients with hypertension (HTN) respond to any given antihypertensive medication. Heterogeneity in pathophysiologic pathways underlying HTN is a…”
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