Search Results - "Cooper, Shawna A."

Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis by Gao, Jinhang, Wei, Bo, de Assuncao, Thiago M., Liu, Zhikui, Hu, Xiao, Ibrahim, Samar, Cooper, Shawna A., Cao, Sheng, Shah, Vijay H., Kostallari, Enis

“…Autophagy plays a crucial role in hepatic homeostasis and its deregulation has been associated with chronic liver disease. However, the effect of autophagy on…”
Get full text

Angiocrine Signaling in Sinusoidal Health and Disease by Cooper, Shawna A, Kostallari, Enis, Shah, Vijay H

“…Liver sinusoidal endothelial cells (LSECs) are key players in maintaining hepatic homeostasis. They also play crucial roles during liver injury by…”
Get more information

TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet-Induced Insulin Resistance in Skeletal Muscle by Koh, Jin-Ho, Johnson, Matthew L, Dasari, Surendra, LeBrasseur, Nathan K, Vuckovic, Ivan, Henderson, Gregory C, Cooper, Shawna A, Manjunatha, Shankarappa, Ruegsegger, Gregory N, Shulman, Gerald I, Lanza, Ian R, Nair, K Sreekumaran

“…Diet-induced insulin resistance (IR) adversely affects human health and life span. We show that muscle-specific overexpression of human mitochondrial…”
Get full text

Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance by Cooper, Shawna A, Whaley-Connell, Adam, Habibi, Javad, Wei, Yongzhong, Lastra, Guido, Manrique, Camila, Stas, Sameer, Sowers, James R

“…Hypertension commonly occurs in conjunction with insulin resistance and other components of the cardiometabolic syndrome. Insulin resistance plays a…”
Get more information

Pathologic light chain amyloidosis oligomer detection in urinary extracellular vesicles as a diagnostic tool for response and progression of disease by Cooper, Shawna A., Dick, Christopher J., Misra, Pinaki, Leung, Nelson, Schinstock, Carrie A., Ramirez-Alvarado, Marina

“…Light Chain (AL) Amyloidosis is a plasma cell dyscrasia producing amyloidogenic light chains (LC) that misfold and form amyloid deposits that cause damage in…”
Get full text

Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat by Whaley-Connell, Adam, Govindarajan, Gurushankar, Habibi, Javad, Hayden, Melvin R, Cooper, Shawna A, Wei, Yongzhong, Ma, Lixin, Qazi, Mahnaz, Link, Daniel, Karuparthi, Poorna R, Stump, Craig, Ferrario, Carlos, Sowers, James R

“…Angiotensin II (ANG II) contributes to cardiac remodeling, hypertrophy, and left ventricular dysfunction. ANG II stimulation of the ANG type 1 receptor…”
Get more information

Mineralocorticoid Receptor Blockade Attenuates Chronic Overexpression of the Renin-Angiotensin-Aldosterone System Stimulation of Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase and Cardiac Remodeling by Stas, Sameer, Whaley-Connell, Adam, Habibi, Javad, Appesh, Lama, Hayden, Melvin R, Karuparthi, Poorna R, Qazi, Mahnaz, Morris, E. Matthew, Cooper, Shawna A, Link, C. Daniel, Stump, Craig, Hay, Meredith, Ferrario, Carlos, Sowers, James R

“…The renin-angiotensin-aldosterone system contributes to cardiac remodeling, hypertrophy, and left ventricular dysfunction. Angiotensin II and aldosterone…”
Get full text

Rosuvastatin, a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, Decreases Cardiac Oxidative Stress and Remodeling in Ren2 Transgenic Rats by Habibi, Javad, Whaley-Connell, Adam, Qazi, Mahnaz A, Hayden, Melvin R, Cooper, Shawna A, Tramontano, Anthony, Thyfault, John, Stump, Craig, Ferrario, Carlos, Muniyappa, Ranganath, Sowers, James R

“…Angiotensin-II (Ang-II)-stimulated increases in nicotinamide adenine dinucleotide phosphate reduced (NADPH) oxidase activity and oxidative stress are known to…”
Get full text

Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic rat by Whaley-Connell, Adam T, Chowdhury, Nazif A, Hayden, Melvin R, Stump, Craig S, Habibi, Javad, Wiedmeyer, Charles E, Gallagher, Patricia E, Tallant, E Ann, Cooper, Shawna A, Link, C Daniel, Ferrario, Carlos, Sowers, James R

“…TG(mRen2)27 (Ren2) transgenic rats overexpress the mouse renin gene, manifest hypertension, and exhibit increased tissue ANG II levels and oxidative stress…”
Get more information

Effect of renin inhibition and AT1R blockade on myocardial remodeling in the transgenic Ren2 rat by Whaley-Connell, Adam, Habibi, Javad, Cooper, Shawna A, Demarco, Vincent G, Hayden, Melvin R, Stump, Craig S, Link, Daniel, Ferrario, Carlos M, Sowers, James R

“…Angiotensin II (Ang II) stimulation of the Ang type 1 receptor (AT(1)R) facilitates myocardial remodeling through NADPH oxidase-mediated generation of…”
Get more information

Omics and AI advance biomarker discovery for liver disease by Wu, Tiffany, Cooper, Shawna A., Shah, Vijay H.

“…New technologies allow the noninvasive detection and staging of asymptomatic alcohol-associated liver disease; further refinement of this approach could…”
Get full text

Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis by Kostallari, Enis, Wei, Bo, Sicard, Delphine, Li, Jiahui, Cooper, Shawna A, Gao, Jinhang, Dehankar, Mrunal, Li, Ying, Cao, Sheng, Yin, Meng, Tschumperlin, Daniel J, Shah, Vijay H

“…The fibrogenic wound-healing response in liver increases stiffness. Stiffness mechanotransduction, in turn, amplifies fibrogenesis. Here, we aimed to…”
Get more information

Insulin resistance, oxidative stress, and podocyte injury: role of rosuvastatin modulation of filtration barrier injury by Whaley-Connell, Adam, DeMarco, Vincent G, Lastra, Guido, Manrique, Camila, Nistala, Ravi, Cooper, Shawna A, Westerly, Blair, Hayden, Melvin R, Wiedmeyer, Charles, Wei, Yongzhong, Sowers, James R

“…There is an emerging relationship between insulin resistance/hyperinsulinemia, oxidative stress, and glomerular injury manifesting as albuminuria. HMG-CoA…”
Get more information

Three-Dimensional Structure of Inner Ear Hair Cell Ribbon Synapses in a Zebrafish Model of Usher Syndrome Type 1B by Riley, Jr, Kenneth C, Koleilat, Alaa, Dugdale, Joseph A, Cooper, Shawna A, Christensen, Trace A, Schimmenti, Lisa A

“…Our understanding of inner ear hair cell ultrastructure has heretofore relied upon two-dimensional imaging; however, serial block-face scanning electron…”
Get more information

Erratum. TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet–Induced Insulin Resistance in Skeletal Muscle. Diabetes 2019;68:1552–1564 by Koh, Jin-Ho, Johnson, Matthew L., Dasari, Surendra, LeBrasseur, Nathan K., Vuckovic, Ivan, Henderson, Gregory C., Cooper, Shawna A., Manjunatha, Shankarappa, Ruegsegger, Gregory N., Shulman, Gerald I., Lanza, Ian R., Nair, K. Sreekumaran

Get full text

Assays for Light Chain Amyloidosis Formation and Cytotoxicity by Blancas-Mejia, Luis M, Misra, Pinaki, Dick, Christopher J, Marin-Argany, Marta, Redhage, Keely R, Cooper, Shawna A, Ramirez-Alvarado, Marina

“…Common biophysical techniques like absorption and fluorescence spectroscopy, microscopy, and light scattering studies have been in use to investigate fibril…”
Get more information

Assessment of renal response with urinary exosomes in patients with AL amyloidosis: A proof of concept by Ramirez‐Alvarado, Marina, Barnidge, David R., Murray, David L., Dispenzieri, Angela, Marin‐Argany, Marta, Dick, Christopher J., Cooper, Shawna A., Nasr, Samih H, Ward, Christopher J., Dasari, Surendra, Jiménez‐Zepeda, Víctor H., Leung, Nelson

“…Immunoglobulin light chain (AL) amyloidosis is a fatal complication of B‐cell proliferation secondary to deposition of amyloid fibrils in various organs…”
Get full text

Attenuation of NADPH Oxidase Activation and Glomerular Filtration Barrier Remodeling With Statin Treatment by Whaley-Connell, Adam, Habibi, Javad, Nistala, Ravi, Cooper, Shawna A, Karuparthi, Poorna R, Hayden, Melvin R, Rehmer, Nathan, DeMarco, Vincent G, Andresen, Bradley T, Wei, Yongzhong, Ferrario, Carlos, Sowers, James R

“…Activation of reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase by angiotensin II is integral to the formation of oxidative stress in the…”
Get full text

Glycolysis in hepatic stellate cells coordinates fibrogenic extracellular vesicle release spatially to amplify liver fibrosis by Khanal, Shalil, Liu, Yuanhang, Bamidele, Adebowale O, Wixom, Alexander Q, Washington, Alexander M, Jalan-Sakrikar, Nidhi, Cooper, Shawna A, Vuckovic, Ivan, Zhang, Song, Zhong, Jun, Johnson, Kenneth L, Charlesworth, M Cristine, Kim, Iljung, Yeon, Yubin, Yoon, Sangwoong, Noh, Yung-Kyun, Meroueh, Chady, Timbilla, Abdul Aziz, Yaqoob, Usman, Gao, Jinhang, Kim, Yohan, Lucien, Fabrice, Huebert, Robert C, Hay, Nissim, Simons, Michael, Shah, Vijay H, Kostallari, Enis

“…Liver fibrosis is characterized by the activation of perivascular hepatic stellate cells (HSCs), the release of fibrogenic nanosized extracellular vesicles…”
Get full text

Proximal tubule microvilli remodeling and albuminuria in the Ren2 transgenic rat by Hayden, Melvin R, Chowdhury, Nazif A, Cooper, Shawna A, Whaley-Connell, Adam, Habibi, Javad, Witte, Lauren, Wiedmeyer, Charles, Manrique, Camila Margarita, Lastra, Guido, Ferrario, Carlos, Stump, Craig, Sowers, James R

“…TG(mRen2)27 (Ren2) transgenic rats overexpress the mouse renin gene, with subsequent elevated tissue ANG II, hypertension, and nephropathy. The proximal tubule…”
Get more information