Search Results - "Cooper, Mark"

Governing the global climate commons: The political economy of state and local action, after the U.S. flip-flop on the Paris Agreement by Cooper, Mark

“…United States withdrawal from the Paris Agreement, which follows well-known principles of common pool resource management, poses a serious challenge, but it…”
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Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future by Kahn, Steven E, Prof, Cooper, Mark E, Prof, Del Prato, Stefano, Prof

“…Summary Glucose metabolism is normally regulated by a feedback loop including islet β cells and insulin-sensitive tissues, in which tissue sensitivity to…”
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Mechanisms of diabetic complications by Forbes, Josephine M, Cooper, Mark E

“…It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic required, but also for its major complications, affecting both…”
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New-Onset Diabetes in Covid-19 by Rubino, Francesco, Amiel, Stephanie A, Zimmet, Paul, Alberti, George, Bornstein, Stefan, Eckel, Robert H, Mingrone, Geltrude, Boehm, Bernhard, Cooper, Mark E, Chai, Zhonglin, Del Prato, Stefano, Ji, Linong, Hopkins, David, Herman, William H, Khunti, Kamlesh, Mbanya, Jean-Claude, Renard, Eric

“…Diabetes is associated with an increased risk of severe Covid-19. New-onset diabetes and metabolic complications of preexisting diabetes, including diabetic…”
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Therapeutic glucocorticoids: mechanisms of actions in rheumatic diseases by Hardy, Rowan S., Raza, Karim, Cooper, Mark S.

“…Therapeutic glucocorticoids have been widely used in rheumatic diseases since they became available over 60 years ago. Despite the advent of more specific…”
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Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease by Thomas, Merlin C., Cooper, Mark E., Zimmet, Paul

“…Key Points Chronic kidney disease (CKD) affects ∼50% of patients with type 2 diabetes mellitus (T2DM), and changes in the epidemiology of T2DM are driving…”
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Glucocorticoids and Bone: Consequences of Endogenous and Exogenous Excess and Replacement Therapy by Hardy, Rowan S, Zhou, Hong, Seibel, Markus J, Cooper, Mark S

“…Osteoporosis associated with long-term glucocorticoid therapy remains a common and serious bone disease. Additionally, in recent years it has become clear that…”
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Potential metabolic and inflammatory pathways between COVID-19 and new-onset diabetes by Sathish, Thirunavukkarasu, Tapp, Robyn J., Cooper, Mark E., Zimmet, Paul

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Breeding drought-tolerant maize hybrids for the US corn-belt: discovery to product by Cooper, Mark, Gho, Carla, Leafgren, Roger, Tang, Tom, Messina, Carlos

“…Germplasm, genetics, phenotyping, and selection, combined with a clear definition of product targets, are the foundation of successful hybrid maize breeding…”
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The Role of Advanced Glycation End Products in Progression and Complications of Diabetes by Goh, Su-Yen, Cooper, Mark E.

“…Context: Diabetic complications appear to be multifactorial in origin, but in particular, the biochemical process of advanced glycation, which is accelerated…”
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YB-1: the Jekyll and Hyde of kidney disease? by Kantharidis, Phillip, Cooper, Mark E

“…Y-box-binding protein 1 is a well-described and important regulator of gene transcription, which is linked to various pathologic conditions, including…”
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Epigenetics: Mechanisms and Implications for Diabetic Complications by Cooper, Mark E, El-Osta, Assam

“…Epigenetic modifications regulate critical functions that underlie chromosome metabolism. Understanding the molecular changes to chromatin structure and the…”
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miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7 by McClelland, Aaron D, Herman-Edelstein, Michal, Komers, Radko, Jha, Jay C, Winbanks, Catherine E, Hagiwara, Shinji, Gregorevic, Paul, Kantharidis, Phillip, Cooper, Mark E

“…The cytokine transforming growth factor (TGF)-β1 plays a central role in diabetic nephropathy (DN) with data implicating the miRNA (miR) miR-21 as a key…”
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Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes by FORBES, Josephine M, COUGHLAN, Melinda T, COOPER, Mark E

“…Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes Josephine M. Forbes 1 2 , Melinda T. Coughlan 1 and Mark E. Cooper 1 2 1 Juvenile Diabetes…”
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Diabetes and Kidney Disease: Role of Oxidative Stress by Jha, Jay C, Banal, Claudine, Chow, Bryna S M, Cooper, Mark E, Jandeleit-Dahm, Karin

“…Intrarenal oxidative stress plays a critical role in the initiation and progression of diabetic kidney disease (DKD). Enhanced oxidative stress results from…”
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Diabetic nephropathy: an insight into molecular mechanisms and emerging therapies by Warren, Annabelle M, Knudsen, Søren T, Cooper, Mark E

“…: Diabetic kidney disease (DKD) is a major cause of morbidity and mortality in diabetes and is the most common cause of proteinuric and non-proteinuric forms…”
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Low- and middle-income countries demonstrate rapid growth of type 2 diabetes: an analysis based on Global Burden of Disease 1990–2019 data by Liu, Jinli, Bai, Ruhai, Chai, Zhonglin, Cooper, Mark E., Zimmet, Paul Z., Zhang, Lei

“…Aims/hypothesis The study aims to quantify the global trend of the disease burden of type 2 diabetes caused by various risks factors by country income tiers…”
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Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells by McNeill, Alisdair, Magalhaes, Joana, Shen, Chengguo, Chau, Kai-Yin, Hughes, Derralyn, Mehta, Atul, Foltynie, Tom, Cooper, J. Mark, Abramov, Andrey Y., Gegg, Matthew, Schapira, Anthony H.V.

“…Heterozygous GBA gene mutations are the most frequent Parkinson’s disease risk factor. Using Parkinson’s disease patient derived fibroblasts McNeill et al…”
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Impact of age, age at diagnosis and duration of diabetes on the risk of macrovascular and microvascular complications and death in type 2 diabetes by Zoungas, Sophia, Woodward, Mark, Li, Qiang, Cooper, Mark E., Hamet, Pavel, Harrap, Stephen, Heller, Simon, Marre, Michel, Patel, Anushka, Poulter, Neil, Williams, Bryan, Chalmers, John

“…Aims/hypothesis Data are inconsistent regarding the associations between age, age at diagnosis of diabetes, diabetes duration and subsequent vascular…”
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UKPDS and the Legacy Effect by Chalmers, John, Cooper, Mark E

“…The United Kingdom Prospective Diabetes Study (UKPDS) continues to produce important evidence concerning the evolution of type 2 diabetes and its management…”
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