Search Results - "Cooper, L J N"

Manufacture of T cells using the Sleeping Beauty system to enforce expression of a CD19-specific chimeric antigen receptor by Singh, H, Moyes, J S E, Huls, M H, Cooper, L J N

“…T cells can be reprogrammed to redirect specificity to tumor-associated antigens (TAAs) through the enforced expression of chimeric antigen receptors (CARs)…”
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The hyperactive Sleeping Beauty transposase SB100X improves the genetic modification of T cells to express a chimeric antigen receptor by Jin, Z, Maiti, S, Huls, H, Singh, H, Olivares, S, Mátés, L, Izsvák, Z, Ivics, Z, Lee, D A, Champlin, R E, Cooper, L J N

“…Sleeping Beauty (SB 3 ) transposon and transposase constitute a DNA plasmid system used for therapeutic human cell genetic engineering. Here we report a…”
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Moving from tinkering in the garage to assembly line production: the manufacture of genetically modified T cells expressing chimeric antigen receptors (CARs) comes on line by Cooper, L J N

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Immunotherapy for chronic lymphocytic leukemia in the era of BTK inhibitors by Kharfan-Dabaja, M A, Wierda, W G, Cooper, L J N

“…Understanding the pathogenesis of CLL has uncovered a plethora of novel targets for human application of monoclonal antibodies, engineered T cells, or…”
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PET imaging of T cells derived from umbilical cord blood by Singh, H, Najjar, A M, Olivares, S, Nishii, R, Mukhopadhyay, U, Alauddin, M, Manuri, P R, Huls, H, Lee, D A, Dotti, G, Bollard, C, Simmons, P J, Shpall, E J, Champlin, R E, Gelovani, J G, Cooper, L J N

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Antithymidylate resistance enables transgene selection and cell survival for T cells in the presence of 5-fluorouracil and antifolates by Rushworth, D, Alpert, A, Santana-Carrero, R, Olivares, S, Spencer, D, Cooper, L J N

“…Antithymidylates (AThy) constitute a class of drugs used in the treatment of cancers such as lung, colon, breast and pancreas. These drugs inhibit DNA…”
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Adoptive cellular immunotherapy for childhood malignancies by Cooper, L J N

“…Clinical trials have established that T cells have the ability to prevent and treat pathogens and tumors. This is perhaps best exemplified by engraftment of…”
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Identifying candidate allogeneic NK-cell donors for hematopoietic stem-cell transplantation based on functional phenotype by Hurton, L V, Siddik, R I, Singh, H, Olivares, S, Rabinovich, B A, Tian, R, Mojsilovic, D, Hildebrand, W, Lee, D A, Kelly, S S, Champlin, R, Shpall, E J, Fernandez-Viña, M, Cooper, L J N

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Epidermal growth factor receptor and variant III targeted immunotherapy by Congdon, Kendra L, Gedeon, Patrick C, Suryadevara, Carter M, Caruso, Hillary G, Cooper, Laurence J N, Heimberger, Amy B, Sampson, John H

“…Immunotherapeutic approaches to cancer have shown remarkable promise. A critical barrier to successfully executing such immune-mediated interventions is the…”
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Characterization of an artificial antigen-presenting cell to propagate cytolytic CD19-specific T cells by Numbenjapon, T, Serrano, L M, Singh, H, Kowolik, C M, Olivares, S, Gonzalez, N, Chang, W C, Forman, S J, Jensen, M C, Cooper, L J N

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Adoptive cellular immunotherapy for childhood malignancies: Pediatric Blood and Marrow Transplantation: State of the Science by COOPER, L. J. N

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Variable Region-Identical Monoclonal Antibodies of Different IgG Subclass Directed to Pseudomonas aeruginosa Lipopolysaccharide O-Specific Side Chain Function Differently by Schreiber, John R., Cooper, Laurence J. N., Diehn, Scott, Dahlhauser, Paul A., Tosi, Michael F., Glass, Debbie D., Patawaran, Montesa, Greenspan, Neil S.

“…Antibodies directed to polysaccharide (PS) antigens of bacteria are crucial to host immunity to infection. The isotypes of antibodies made to PS, however, are…”
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Manufacturing of gene-modified cytotoxic T lymphocytes for autologous cellular therapy for lymphoma by Cooper, L.J.N., Ausubel, L., Gutierrez, M., Stephan, S., Shakeley, R., Olivares, S., Serrano, L.M., Burton, L., Jensen, M.C.V., Forman, S.J., Digiusto, D.L.

“…The production of therapeutic T-cell populations for adoptive immunotherapy of cancer requires extensive ex vivo cell processing, including the isolation or…”
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Preparing clinical grade Ag-specific T cells for adoptive immunotherapy trials by Digiusto, D.L., PhD, Cooper, L.J.N., MD, PhD

“…The production of clinical-grade T cells for adoptive immunotherapy has evolved from the ex vivo numerical expansion of tumor-infiltrating lymphocytes to…”
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Engineered CD20-specific primary human cytotoxic T lymphocytes for targeting B-cell malignancy by Jensen, M.C., Cooper, L.J.N., Wu, A.M., Forman, S.J., Raubitschek, A.

“…Immunotherapy for B-cell lymphomas has evolved significantly -with the advent of CD20-targeted Ab-based therapeutics. Strategies to invoke or augment cellular…”
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RBC T activation and hemolysis: implications for pediatric transfusion management by Crookston, K.P., Reiner, A.P., Cooper, L.J.N., Sacher, R.A., Blajchman, M.A., Heddle, N.M.

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Variable domain-identical antibodies exhibit IgG subclass-related differences in affinity and kinetic constants as determined by surface plasmon resonance by Cooper, L J, Robertson, D, Granzow, R, Greenspan, N S

“…We have analysed the binding of variable domain-identical mouse monoclonal antibodies (mAb) of the IgG3, IgG1 and IgG2b subclasses, as well as F(ab')2…”
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Role of heavy chain constant domains in antibody-antigen interaction. Apparent specificity differences among streptococcal IgG antibodies expressing identical variable domains by Cooper, LJ, Shikhman, AR, Glass, DD, Kangisser, D, Cunningham, MW, Greenspan, NS

“…In this report, we examine the influence of CH domains on antibody specificity, in the context of variable epitope density on bacteria and synthetic…”
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H chain C domains influence the strength of binding of IgG for streptococcal group A carbohydrate by Cooper, LJ, Schimenti, JC, Glass, DD, Greenspan, NS

“…We have produced a panel of murine anti-streptococcal mAbs, expressing identical V domains and different H chain C domains, corresponding to the IgG3, IgG1,…”
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Cooperative binding of two antibodies to independent antigens by an Fc-dependent mechanism by Greenspan, N S, Dacek, D A, Cooper, L J

“…Binding of a murine N-acetylglucosamine (GlcNAc)-specific IgG3 monoclonal antibody to a solid phase expressing GlcNAc determinants and phosphocholine (PC)…”
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