Search Results - "Cooper, K D"

Long‐Term Controlled Normoglycemia in Diabetic Non‐Human Primates After Transplantation with hCD46 Transgenic Porcine Islets by Van Der Windt, D. J., Bottino, R., Casu, A., Campanile, N., Smetanka, C., He, J., Murase, N., Hara, H., Ball, S., Loveland, B. E, Ayares, D., Lakkis, F. G., Cooper, D. K. C., Trucco, M.

“…Xenotransplantation of porcine islets into diabetic non‐human primates is characterized by (i) an initial massive graft loss possibly due to the instant…”
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Xenotransplantation—the current status and prospects by Cooper, D K C, Gaston, R, Eckhoff, D, Ladowski, J, Yamamoto, T, Wang, L, Iwase, H, Hara, H, Tector, M, Tector, A J

“…Abstract Introduction There is a continuing worldwide shortage of organs from deceased human donors for transplantation into patients with end-stage organ…”
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Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients by Ezzelarab, M. B., Zhang, H., Guo, H., Lu, L., Zahorchak, A. F., Wiseman, R. W., Nalesnik, M. A., Bhama, J. K., Cooper, D. K. C., Thomson, A. W.

“…The ability of regulatory T cells (Treg) to prolong allograft survival and promote transplant tolerance in lymphodepleted rodents is well established. Few…”
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Regulatory Dendritic Cell Infusion Prolongs Kidney Allograft Survival in Nonhuman Primates by Ezzelarab, M. B., Zahorchak, A. F., Lu, L., Morelli, A. E., Chalasani, G., Demetris, A. J., Lakkis, F. G., Wijkstrom, M., Murase, N., Humar, A., Shapiro, R., Cooper, D. K. C., Thomson, A. W.

“…We examined the influence of regulatory dendritic cells (DCreg), generated from cytokine‐mobilized donor blood monocytes in vitamin D3 and IL‐10, on renal…”
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A region within the third extracellular loop of rat Aquaporin 6 precludes trafficking to plasma membrane in a heterologous cell line by Soler, D. C., Kowatz, T., Sloan, A. E., McCormick, T. S., Cooper, K. D., Stepanyan, R., Engel, A., Vahedi-Faridi, A.

“…The inability to over-express Aquaporin 6 (AQP6) in the plasma membrane of heterologous cells has hampered efforts to further characterize the function of this…”
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Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice by Casu, A, Bottino, R, Balamurugan, A. N, Hara, H, van der Windt, D. J, Campanile, N, Smetanka, C, Cooper, D. K. C, Trucco, M

“…Aims/hypothesis Attempts to use an alternative source of islets to restore glucose homeostasis in diabetic patients require preclinical islet…”
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Recipient Tissue Factor Expression Is Associated With Consumptive Coagulopathy in Pig‐to‐Primate Kidney Xenotransplantation by Lin, C. C., Ezzelarab, M., Shapiro, R., Ekser, B., Long, C., Hara, H., Echeverri, G., Torres, C., Watanabe, H., Ayares, D., Dorling, A., Cooper, D. K. C.

“…Consumptive coagulopathy (CC) remains a challenge in pig‐to‐primate organ xenotransplantation (Tx). This study investigated the role of tissue factor (TF)…”
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Impact of Thrombocytopenia on Survival of Baboons with Genetically Modified Pig Liver Transplants: Clinical Relevance by Ekser, B., Long, C., Echeverri, G. J., Hara, H., Ezzelarab, M., Lin, C. C., De Vera, M. E., Wagner, R., Klein, E., Wolf, R. F., Ayares, D., Cooper, D. K.C., Gridelli, B.

“…A lack of deceased human donor livers leads to a significant mortality in patients with acute‐on‐chronic or acute (fulminant) liver failure or with primary…”
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Visualization of atherosclerosis as detected by coronary artery calcium and carotid intima-media thickness reveals significant atherosclerosis in a cross-sectional study of psoriasis patients in a tertiary care center by Santilli, S, Kast, D R, Grozdev, I, Cao, L, Feig, R L, Golden, J B, Debanne, S M, Gilkeson, R C, Orringer, C E, McCormick, T S, Ward, N L, Cooper, K D, Korman, N J

“…Psoriasis is a chronic inflammatory disease of the skin and joints that may also have systemic inflammatory effects, including the development of…”
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Endoscopic Gastric Submucosal Transplantation of Islets (ENDO‐STI): Technique and Initial Results in Diabetic Pigs by Echeverri, G. J., McGrath, K., Bottino, R., Hara, H., Dons, E. M., Van Der Windt, D. J., Ekser, B., Casu, A., Houser, S., Ezzelarab, M., Wagner, R., Trucco, M., Lakkis, F. G., Cooper, D. K. C.

“…The results of transplantation of human donor islets into the portal vein (PV) in patients with diabetes are encouraging. However, there are complications, for…”
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Persistence of Indirect but Not Direct T Cell Xenoresponses in Baboon Recipients of Pig Cell and Organ Transplants by Buhler, L., Illigens, B. M.‐W., Nadazdin, O., Tena, A., Lee, S., Sachs, D. H., Cooper, D. K. C., Benichou, G.

“…We investigated the contributions of direct and indirect T cell antigen recognition pathways to the immune response to porcine antigens in naïve baboons and…”
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Radiation therapy in the management of unilesional primary cutaneous T-cell lymphomas by Chan, D.V., Aneja, S., Honda, K., Carlson, S., Yao, M., Katcher, J., Cooper, K.D.

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Renal and Cardiac Endothelial Heterogeneity Impact Acute Vascular Rejection in Pig‐to‐Baboon Xenotransplantation by Knosalla, C., Yazawa, K., Behdad, A., Bodyak, N., Shang, H., Bühler, L., Houser, S., Gollackner, B., Griesemer, A., Schmitt‐Knosalla, I., Schuurman, H.‐J., Awwad, M., Sachs, D. H., Cooper, D. K. C., Yamada, K., Usheva, A., Robson, S. C.

“…Xenograft outcomes are dictated by xenoantigen expression, for example, Gal α1, 3Gal (Gal), but might also depend on differing vascular responses. We…”
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Investigation of Lymphocyte Depletion and Repopulation Using Alemtuzumab (Campath‐1H) in Cynomolgus Monkeys by Van Der Windt, D. J., Smetanka, C., Macedo, C., He, J., Lakomy, R., Bottino, R., Ekser, B., Echeverri, G. J., Metes, D., Ijzermans, J. N. M., Trucco, M., Cooper, D. K. C., Lakkis, F. G.

“…As the target CD52 molecule is expressed on erythrocytes of most nonhuman primate strains, using alemtuzumab in these species would cause massive hemolysis…”
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Ex Vivo‐Expanded Cynomolgus Macaque Regulatory T Cells Are Resistant to Alemtuzumab‐Mediated Cytotoxicity by Dons, E. M., Raimondi, G., Zhang, H., Zahorchak, A. F., Bhama, J. K., Lu, L., Ezzelarab, M., Ijzermans, J. N. M., Cooper, D. K. C., Thomson, A. W.

“…Alemtuzumab (Campath‐1H) is a humanized monoclonal antibody (Ab) directed against CD52 that depletes lymphocytes and other leukocytes, mainly by…”
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High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response by BÜHLER, L, AWWAD, M, DOWN, J. D, SYKES, M, ANDREWS, D, SACKSTEIN, R, WHITE-SCHARF, M. E, SACHS, D. H, COOPER, D. K. C, BASKER, M, GOJO, S, WATTS, A, TRETER, S, NASH, K, ORAVEC, G, CHANG, Q, THALL, A

“…In pig-to-primate organ transplantation, hyperacute rejection can be prevented, but the organ is rejected within days by acute vascular rejection, in which…”
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Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates by BÜHLER, L, BASKER, M, SACHS, D. H, SACKSTEIN, R, ROBSON, S. C, COOPER, D. K. C, ALWAYN, I. P. J, GOEPFERT, C, KITAMURA, H, KAWAI, T, GOJO, S, KOZLOWSKI, T, IERINO, F. L, AWWAD, M

“…Efforts to achieve tolerance to transplanted pig organs in nonhuman primates by the induction of a state of mixed hematopoietic chimerism have been associated…”
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Successful cutaneous delivery of the photosensitizer silicon phthalocyanine 4 for photodynamic therapy by Lam, M., Hsia, A. H., Liu, Y., Guo, M., Swick, A. R., Berlin, J. C., McCormick, T. S., Kenney, M. E., Oleinick, N. L., Cooper, K. D., Baron, E. D.

“…Summary Background.  Photodynamic therapy (PDT) has been shown to be effective in the treatment of malignancies of a variety of organ systems, including the…”
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The respective relevance of sensitization to alloantigens and xenoantigens in pig organ xenotransplantation by Cooper, D.K.C., Habibabady, Z., Kinoshita, K., Hara, H., Pierson, R.N.

“…Antibody-mediated rejection is a major cause of graft injury and contributes to failure of pig xenografts in nonhuman primates (NHPs). Most ‘natural’ or…”
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Pig‐to‐Monkey Islet Xenotransplantation Using Multi‐Transgenic Pigs by Bottino, R., Wijkstrom, M., van der Windt, D. J., Hara, H., Ezzelarab, M., Murase, N., Bertera, S., He, J., Phelps, C., Ayares, D., Cooper, D. K. C., Trucco, M.

“…The generation of pigs with genetic modifications has significantly advanced the field of xenotransplantation. New genetically engineered pigs were produced on…”
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