Search Results - "Cooper, Jonathan L"

Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia by Dovey, Oliver M., Cooper, Jonathan L., Mupo, Annalisa, Grove, Carolyn S., Lynn, Claire, Conte, Nathalie, Andrews, Robert M., Pacharne, Suruchi, Tzelepis, Konstantinos, Vijayabaskar, M.S., Green, Paul, Rad, Roland, Arends, Mark, Wright, Penny, Yusa, Kosuke, Bradley, Allan, Varela, Ignacio, Vassiliou, George S.

“…NPM1 mutations define the commonest subgroup of acute myeloid leukemia (AML) and frequently co-occur with FLT3 internal tandem duplications (ITD) or, less…”
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Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice by Vassiliou, George S, Cooper, Jonathan L, Rad, Roland, Li, Juan, Rice, Stephen, Uren, Anthony, Rad, Lena, Ellis, Peter, Andrews, Rob, Banerjee, Ruby, Grove, Carolyn, Wang, Wei, Liu, Pentao, Wright, Penny, Arends, Mark, Bradley, Allan

“…George Vassiliou, Allan Bradley and colleagues perform a Sleeping Beauty transposon mutagenesis screen to identify insertions that cooperate with mutant Npm1…”
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Identification of a germline F692L drug resistance variant in cis with Flt3-internal tandem duplication in knock-in mice by Dovey, Oliver M, Chen, Bin, Mupo, Annalisa, Friedrich, Mathias, Grove, Carolyn S, Cooper, Jonathan L, Lee, Benjamin, Varela, Ignacio, Huang, Yue, Vassiliou, George S

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The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia by Papaioannou, Dimitrios, Petri, Andreas, Dovey, Oliver M., Terreri, Sara, Wang, Eric, Collins, Frances A., Woodward, Lauren A., Walker, Allison E., Nicolet, Deedra, Pepe, Felice, Kumchala, Prasanthi, Bill, Marius, Walker, Christopher J., Karunasiri, Malith, Mrózek, Krzysztof, Gardner, Miranda L., Camilotto, Virginia, Zitzer, Nina, Cooper, Jonathan L., Cai, Xiongwei, Rong-Mullins, Xiaoqing, Kohlschmidt, Jessica, Archer, Kellie J., Freitas, Michael A., Zheng, Yi, Lee, Robert J., Aifantis, Iannis, Vassiliou, George, Singh, Guramrit, Kauppinen, Sakari, Bloomfield, Clara D., Dorrance, Adrienne M., Garzon, Ramiro

“…Long non-coding RNAs (lncRNAs) are important regulatory molecules that are implicated in cellular physiology and pathology. In this work, we dissect the…”
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Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus by Dhami, Pawandeep, Bruce, Alexander W, Jim, Johanna H, Dillon, Shane C, Hall, Amanda, Cooper, Jonathan L, Bonhoure, Nicolas, Chiang, Kelly, Ellis, Peter D, Langford, Cordelia, Andrews, Robert M, Vetrie, David

“…The SCL (TAL1) transcription factor is a critical regulator of haematopoiesis and its expression is tightly controlled by multiple cis-acting regulatory…”
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SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness by Nguyen, Chi Huu, Glüxam, Tobias, Schlerka, Angela, Bauer, Katharina, Grandits, Alexander M., Hackl, Hubert, Dovey, Oliver, Zöchbauer-Müller, Sabine, Cooper, Jonathan L., Vassiliou, George S., Stoiber, Dagmar, Wieser, Rotraud, Heller, Gerwin

“…Acute myeloid leukemia (AML) is a heterogeneous disease with respect to its genetic and molecular basis and to patients´ outcome. Clinical, cytogenetic, and…”
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Author Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia by Papaioannou, Dimitrios, Petri, Andreas, Dovey, Oliver M., Terreri, Sara, Wang, Eric, Collins, Frances A., Woodward, Lauren A., Walker, Allison E., Nicolet, Deedra, Pepe, Felice, Kumchala, Prasanthi, Bill, Marius, Walker, Christopher J., Karunasiri, Malith, Mrózek, Krzysztof, Gardner, Miranda L., Camilotto, Virginia, Zitzer, Nina, Cooper, Jonathan L., Cai, Xiongwei, Rong-Mullins, Xiaoqing, Kohlschmidt, Jessica, Archer, Kellie J., Freitas, Michael A., Zheng, Yi, Lee, Robert J., Aifantis, Iannis, Vassiliou, George, Singh, Guramrit, Kauppinen, Sakari, Bloomfield, Clara D., Dorrance, Adrienne M., Garzon, Ramiro

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Publisher Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia by Papaioannou, Dimitrios, Petri, Andreas, Dovey, Oliver M., Terreri, Sara, Wang, Eric, Collins, Frances A., Woodward, Lauren A., Walker, Allison E., Nicolet, Deedra, Pepe, Felice, Kumchala, Prasanthi, Bill, Marius, Walker, Christopher J., Karunasiri, Malith, Mrózek, Krzysztof, Gardner, Miranda L., Camilotto, Virginia, Zitzer, Nina, Cooper, Jonathan L., Cai, Xiongwei, Rong-Mullins, Xiaoqing, Kohlschmidt, Jessica, Archer, Kellie J., Freitas, Michael A., Zheng, Yi, Lee, Robert J., Aifantis, Iannis, Vassiliou, George, Singh, Guramrit, Kauppinen, Sakari, Bloomfield, Clara D., Dorrance, Adrienne M., Garzon, Ramiro

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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SETBP1 overexpression acts in the place of class-defining mutations to drive FLT3-ITD–mutant AML by Pacharne, Suruchi, Dovey, Oliver M., Cooper, Jonathan L., Gu, Muxin, Friedrich, Mathias J., Rajan, Sandeep S., Barenboim, Maxim, Collord, Grace, Vijayabaskar, M.S., Ponstingl, Hannes, De Braekeleer, Etienne, Bautista, Ruben, Mazan, Milena, Rad, Roland, Tzelepis, Konstantinos, Wright, Penny, Gozdecka, Malgorzata, Vassiliou, George S.

“…Advances in cancer genomics have revealed genomic classes of acute myeloid leukemia (AML) characterized by class-defining mutations, such as chimeric fusion…”
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Setbp1 Overexpression Acts in the Place of Class-Defining Somatic Mutations to Drive Mouse and Human FLT3-ITD-Mutant AMLs by Pacharne, Suruchi, Dovey, Oliver M., Cooper, Jonathan L, Gu, Muxin, Baskar, Vijay, Friedrich, Mathias J, Gozdecka, Malgorzata, Rajan, Sandeep S, De Braekeleer, Etienne, Barenboim, Maxim, Collord, Grace, Postingl, Hannes, Bautista, Ruben, Mazan, Milena, Rad, Roland, Tzelepis, Konstantinos, Wright, Penny, Vassiliou, George S.

“…Setbp1 overexpression acts in the place of class-defining somatic mutations to drive mouse and human FLT3-ITD-mutant AMLs Suruchi Pacharne,1,2 Oliver M…”
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Abstract 1158: Modulation of splicing by inhibiting the kinase SRPK1 as a novel therapeutic strategy in myeloid leukemia by Tzelepis, Konstantinos, Braekeleer, Etienne De, Seiler, Michael, Barbieri, Isaia, Robson, Sam, Yang, Yu Hsuen, Gozdecka, Malgorzata, Dudek, Monika, Collord, Grace, Dovey, Oliver M., Metzakopian, Emmanouil, Garyfallos, Dimitrios, Cooper, Jonathan L., Buonamici, Silvia, Ponstingl, Hannes, Stratton, Michael R., Bradley, Allan, Huntly, Brian J., Pina, Cristina, Kouzarides, Tony, Yusa, Kosuke, Vassiliou, George S.

“…Abstract Acute myeloid leukemia (AML) is an aggressive cancer with a poor prognosis, for which the therapeutic landscape has changed little for decades…”
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A Crispr/Cas9 Drop-out Screen Identifies Genome-Wide Genetic Valnerubilities in Acute Myeloid Leukaemia by Tzelepis, Konstantinos, Koike-Yusa, Hiroko, De Braekeleer, Etienne, Li, Yilong, Metzakopian, Emmanouil, Dovey, Oliver M., Mupo, Annalisa, Grinkevich, Vera, Mazan, Milena M., Gozdecka, Malgorzata, Cooper, Jonathan L., Patel, Miten, McKerrell, Thomas David Hardman, Chen, Bin, Ponstingl, Hannes, Huntly, Brian J.P, McDermott, Ultan, Saez-Rodriguez, Julio, Iorio, Francesco, Yusa, Kosuke, Vassiliou, George S.

“…Despite progress in understanding its genomics and molecular pathogenesis, the therapeutic landscape of acute myeloid leukaemia (AML) has changed little in the…”
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Genomic Approaches Uncover Increasing Complexities in the Regulatory Landscape at the Human SCL by Dhami, Pawandeep, Bruce, Alexander W, Jim, Johanna H, Dillon, Shane C, Hall, Amanda, Cooper, Jonathan L, Bonhoure, Nicolas, Chiang, Kelly, Ellis, Peter D, Langford, Cordelia, Andrews, Robert M, Vetrie, David

“…The SCL (TAL1) transcription factor is a critical regulator of haematopoiesis and its expression is tightly controlled by multiple cis-acting regulatory…”
Get full text