Search Results - "Cooper, J N"

Membrane-bound IL-21 promotes sustained ex vivo proliferation of human natural killer cells by Denman, Cecele J, Senyukov, Vladimir V, Somanchi, Srinivas S, Phatarpekar, Prasad V, Kopp, Lisa M, Johnson, Jennifer L, Singh, Harjeet, Hurton, Lenka, Maiti, Sourindra N, Huls, M Helen, Champlin, Richard E, Cooper, Laurence J N, Lee, Dean A

“…NK cells have therapeutic potential for a wide variety of human malignancies. However, because NK cells expand poorly in vitro, have limited life spans in…”
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Engineering lymph node homing of ex vivo–expanded human natural killer cells via trogocytosis of the chemokine receptor CCR7 by Somanchi, Srinivas S., Somanchi, Anitha, Cooper, Laurence J.N., Lee, Dean A.

“…Natural killer (NK) cells have gained significant attention in adoptive immunotherapy for cancer. Consequently, novel methods of clinical-grade expansion of NK…”
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Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection by Kumaresan, Pappanaicken R., Manuri, Pallavi R., Albert, Nathaniel D., Maiti, Sourindra, Singh, Harjeet, Mi, Tiejuan, Roszik, Jason, Rabinovich, Brian, Olivares, Simon, Krishnamurthy, Janani, Zhang, Ling, Najjar, Amer M., Huls, M. Helen, Lee, Dean A., Champlin, Richard E., Kontoyiannis, Dimitrios P., Cooper, Laurence J. N.

“…Clinical-grade T cells are genetically modified ex vivo to express chimeric antigen receptors (CARs) to redirect their specificity to target tumor-associated…”
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Antigen presenting cell-mediated expansion of human umbilical cord blood yields log-scale expansion of natural killer cells with anti-myeloma activity by Shah, Nina, Martin-Antonio, Beatriz, Yang, Hong, Ku, Stephanie, Lee, Dean A, Cooper, Laurence J N, Decker, William K, Li, Sufang, Robinson, Simon N, Sekine, Takuya, Parmar, Simrit, Gribben, John, Wang, Michael, Rezvani, Katy, Yvon, Eric, Najjar, Amer, Burks, Jared, Kaur, Indreshpal, Champlin, Richard E, Bollard, Catherine M, Shpall, Elizabeth J

“…Natural killer (NK) cells are important mediators of anti-tumor immunity and are active against several hematologic malignancies, including multiple myeloma…”
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Chimeric antigen receptor (CAR)-specific monoclonal antibody to detect CD19-specific T cells in clinical trials by Jena, Bipulendu, Maiti, Sourindra, Huls, Helen, Singh, Harjeet, Lee, Dean A, Champlin, Richard E, Cooper, Laurence J N

“…Clinical trials targeting CD19 on B-cell malignancies are underway with encouraging anti-tumor responses. Most infuse T cells genetically modified to express a…”
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Economic burden of rheumatoid arthritis: a systematic review by COOPER, N. J

“…Objective. To summarize the state of knowledge with regard to the economic impact of rheumatoid arthritis (RA) and to highlight any weaknesses in the work…”
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Multi-antigen intranasal vaccine protects against challenge with sarbecoviruses and prevents transmission in hamsters by Leekha, Ankita, Saeedi, Arash, Sefat, K M Samiur Rahman, Kumar, Monish, Martinez-Paniagua, Melisa, Damian, Adrian, Kulkarni, Rohan, Reichel, Kate, Rezvan, Ali, Masoumi, Shalaleh, Liu, Xinli, Cooper, Laurence J. N., Sebastian, Manu, Sands, Courtney M., Das, Vallabh E., Patel, Nimesh B., Hurst, Brett, Varadarajan, Navin

“…Immunization programs against SARS-CoV-2 with commercial intramuscular vaccines prevent disease but are less efficient in preventing infections. Mucosal…”
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An intranasal nanoparticle STING agonist protects against respiratory viruses in animal models by Leekha, Ankita, Saeedi, Arash, Kumar, Monish, Sefat, K. M. Samiur Rahman, Martinez-Paniagua, Melisa, Meng, Hui, Fathi, Mohsen, Kulkarni, Rohan, Reichel, Kate, Biswas, Sujit, Tsitoura, Daphne, Liu, Xinli, Cooper, Laurence J. N., Sands, Courtney M., Das, Vallabh E., Sebastian, Manu, Hurst, Brett L., Varadarajan, Navin

“…Respiratory viral infections cause morbidity and mortality worldwide. Despite the success of vaccines, vaccination efficacy is weakened by the rapid emergence…”
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Mental health, identity and informal education opportunities for adolescents with experience of living in state care: a role for digital storytelling by Hammond, Simon P., Cooper, N.J., Jordan, P.

“…The mental health difficulties and educational trajectories of adolescents with care-experience is a pervasive international concern. This article explores how…”
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An investigation of EEG, genetic and cognitive markers of treatment response to antidepressant medication in patients with major depressive disorder: A pilot study by Spronk, D, Arns, M, Barnett, K.J, Cooper, N.J, Gordon, E

“…Abstract The aim of this study was to investigate if biomarkers in QEEG, genetic and neuropsychological measures are suitable for the prediction of…”
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Meta-analysis of randomized clinical trials comparing open and laparoscopic inguinal hernia repair by Memon, M. A., Cooper, N. J., Memon, B., Memon, M. I., Abrams, K. R.

“…Background: The aim was to conduct a meta‐analysis of the randomized evidence to determine the relative merits of laparoscopic (LIHR) and open (OIHR) inguinal…”
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Reprogramming CD19-Specific T Cells with IL-21 Signaling Can Improve Adoptive Immunotherapy of B-Lineage Malignancies by SINGH, Harjeet, FIGLIOLA, Matthew J, CHAMPLIN, Richard E, COOPER, Laurence J. N, DAWSON, Margaret J, HULS, Helen, OLIVARES, Simon, SWITZER, Kirsten, MI, Tiejuan, MAITI, Sourindra, KEBRIAEI, Partow, LEE, Dean A

“…Improving the therapeutic efficacy of T cells expressing a chimeric antigen receptor (CAR) represents an important goal in efforts to control B-cell…”
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Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia by Calado, R T, Cooper, J N, Padilla-Nash, H M, Sloand, E M, Wu, C O, Scheinberg, P, Ried, T, Young, N S

“…In cell and animal models, telomere erosion promotes chromosomal instability via breakage-fusion-bridge cycles, contributing to the early stages of…”
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Very rapid cloning, expression and identifying specificity of T-cell receptors for T-cell engineering by Zong, Shan, Mi, Tiejuan, Flores, 2nd, Leo G, Alpert, Amir, Olivares, Simon, Patel, Krina, Maiti, Sourindra, Mcnamara, George, Cooper, Laurence J N, Torikai, Hiroki

“…Neoantigens can be predicted and in some cases identified using the data obtained from the whole exome sequencing and transcriptome sequencing of tumor cells…”
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Visualizing fewer than 10 mouse T cells with an enhanced firefly luciferase in immunocompetent mouse models of cancer by Rabinovich, Brian A, Ye, Yang, Etto, Tamara, Chen, Jie Qing, Levitsky, Hyam I, Overwijk, Willem W, Cooper, Laurence J.N, Gelovani, Juri, Hwu, Patrick

“…Antigen specific T cell migration to sites of infection or cancer is critical for an effective immune response. In mouse models of cancer, the number of…”
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CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells by KOWOLIK, Claudia M, TOPP, Max S, GONZALEZ, Sergio, PFEIFFER, Timothy, OLIVARES, Simon, GONZALEZ, Nancy, SMITH, David D, FORMAN, Stephen J, JENSEN, Michael C, COOPER, Laurence J. N

“…Chimeric antigen receptors (CAR) combine an antigen-binding domain with a CD3-zeta signaling motif to redirect T-cell specificity to clinically important…”
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Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations by Deniger, Drew C, Yu, Jianqiang, Huls, M Helen, Figliola, Matthew J, Mi, Tiejuan, Maiti, Sourindra N, Widhopf, 2nd, George F, Hurton, Lenka V, Thokala, Radhika, Singh, Harjeet, Olivares, Simon, Champlin, Richard E, Wierda, William G, Kipps, Thomas J, Cooper, Laurence J N

“…T cells modified with chimeric antigen receptors (CARs) targeting CD19 demonstrated clinical activity against some B-cell malignancies. However, this is often…”
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Extended Radio Emission in MOJAVE Blazars: Challenges to Unification by Kharb, P, Lister, M. L, Cooper, N. J

“…We present the results of a study on the kiloparsec-scale radio emission in the complete flux density limited MOJAVE sample, comprising 135 radio-loud active…”
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Epidermal growth factor receptor and variant III targeted immunotherapy by Congdon, Kendra L, Gedeon, Patrick C, Suryadevara, Carter M, Caruso, Hillary G, Cooper, Laurence J N, Heimberger, Amy B, Sampson, John H

“…Immunotherapeutic approaches to cancer have shown remarkable promise. A critical barrier to successfully executing such immune-mediated interventions is the…”
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Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells by KAHLON, Kanwarpal S, BROWN, Christine, COOPER, Laurence J. N, RAUBITSCHEK, Andrew, FORMAN, Stephen J, JENSEN, Michael C

“…The interleukin (IL) 13 receptor alpha2 (IL13Ralpha2) is a glioma-restricted cell-surface epitope not otherwise detected within the central nervous system…”
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